Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat
Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Research design and methods: Sixty-three subjects with normal LV func...
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| Published in | International Journal of Obesity Vol. 36; no. 3; pp. 422 - 430 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
01.03.2012
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Objective:
To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function.
Research design and methods:
Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4±2.0 kg m
−2
) and 30 obese (BMI: 41.8±6 kg m
−2
) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy.
Results:
EFV and MTGC were positively correlated (
r
=0.52,
P
<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141±18 versus 79±7 ml,
P
=0.0001; 1.0±0.1 versus 0.6±0.1%,
P
=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213±34 versus 141±18 ml,
P
=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (
P
<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=−0.38,
P
=0.01), suggesting an impact of cardiac steatosis in cardiac function.
Conclusions:
These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. |
|---|---|
| AbstractList | Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Research design and methods: Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 [+ or -] 2.0 kg [m.sup.2]) and 30 obese (BMI: 41.8 ± 6kg [m.sup.-2]) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. Results: EFV and MTGC were positively correlated (r = 0.52, P< 0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 [+ or -] 7 ml, P = 0.0001;1.0 ± 0.1 versus 0.6 ± 0.1%, P = 0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P = 0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β = 0.38, P = 0.01), suggesting an impact of cardiac steatosis in cardiac function. Conclusions: These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. International Journal of Obesity (2012) 36, 422- 430; doi:10.1038/ijo.2011.117;published online 5 July 2011 Keywords: epicardial fat; myocardial triglyceride content; proton magnetic resonance spectroscopy; cardiovascular magnetic resonance imaging; cardiac steatosis Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Research design and methods: Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4±2.0 kg m −2 ) and 30 obese (BMI: 41.8±6 kg m −2 ) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. Results: EFV and MTGC were positively correlated ( r =0.52, P <0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141±18 versus 79±7 ml, P =0.0001; 1.0±0.1 versus 0.6±0.1%, P =0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213±34 versus 141±18 ml, P =0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters ( P <0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=−0.38, P =0.01), suggesting an impact of cardiac steatosis in cardiac function. Conclusions: These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. International Journal of Obesity (2012) 36, 422- 430; doi:10.1038/ijo.2011.117;published online 5 July 2011 To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m(-2)) and 30 obese (BMI: 41.8 ± 6 kg m(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. EFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 ± 7 ml, P=0.0001; 1.0 ± 0.1 versus 0.6 ± 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function. These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function.Research design and methods: Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4+/-2.0 kg m super(-2)) and 30 obese (BMI: 41.8 plus or minus 6 kg m super(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. Results: EFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 plus or minus 18 versus 79 plus or minus 7 ml, P=0.0001; 1.0 plus or minus 0.1 versus 0.6 plus or minus 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 plus or minus 34 versus 141 plus or minus 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume ( beta =-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function. Conclusions: These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function. Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m(-2)) and 30 obese (BMI: 41.8 ± 6 kg m(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy. EFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 ± 7 ml, P=0.0001; 1.0 ± 0.1 versus 0.6 ± 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume ([beta]=-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function. These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function.OBJECTIVETo assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat depots are linked to metabolic disorders or myocardial function.Sixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m(-2)) and 30 obese (BMI: 41.8 ± 6 kg m(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy.RESEARCH DESIGN AND METHODSSixty-three subjects with normal LV function and no coronary artery disease, including 33 lean (BMI: 21.4 ± 2.0 kg m(-2)) and 30 obese (BMI: 41.8 ± 6 kg m(-2)) patients, underwent 3-T cardiovascular MRI, and anthropometric, biological and visceral abdominal fat (VAT) assessments. EFV was measured by short-axis slice imaging and myocardial (intra-myocellular) TG content was measured by proton magnetic resonance spectroscopy.EFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 ± 7 ml, P=0.0001; 1.0 ± 0.1 versus 0.6 ± 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function.RESULTSEFV and MTGC were positively correlated (r=0.52, P<0.0001), and were both strongly correlated with age, BMI, waist circumference and VAT, but not with severity of obesity. EFV and MTGC were significantly higher in obese patients than in lean controls (141 ± 18 versus 79 ± 7 ml, P=0.0001; 1.0 ± 0.1 versus 0.6 ± 0.1%, P=0.01, respectively), but some differences were found between the two cardiac depots: EFV was higher in diabetic obese subjects as compared with that in non-diabetic obese subjects (213 ± 34 versus 141 ± 18 ml, P=0.03), and was correlated with parameters of glucose tolerance (fasting plasma glucose, insulin and HOMA-IR), whereas MTGC was not. EFV and MTGC were both associated with parameters of lipid profile or inflammation (TGs, CRP). Remarkably, this was VAT-dependent, as only VAT remained independently associated with metabolic parameters (P<0.01). Concerning myocardial function, MTGC was the only parameter independently associated with stroke volume (β=-0.38, P=0.01), suggesting an impact of cardiac steatosis in cardiac function.These data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition.CONCLUSIONSThese data show that VAT dominates the relationship between EFV, MTGC and metabolic measures, and uncover specific partitioning of cardiac ectopic lipid deposition. |
| Audience | Academic |
| Author | Gaborit, B Boullu, S Jacquier, A Cuisset, T Moro, P J Clément, K Morange, P Bernard, M Alessi, M-C Dadoun, F Dutour, A Kober, F |
| Author_xml | – sequence: 1 givenname: B surname: Gaborit fullname: Gaborit, B email: benedicte.gaborit@ap-hm.fr organization: Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Faculté de Médecine, INSERM U626, Université de la Méditerranée – sequence: 2 givenname: F surname: Kober fullname: Kober, F organization: Université de la Méditerranée, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS no. 6612 – sequence: 3 givenname: A surname: Jacquier fullname: Jacquier, A organization: Université de la Méditerranée, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS no. 6612, Department of Radiology, CHU Timone – sequence: 4 givenname: P J surname: Moro fullname: Moro, P J organization: Université de la Méditerranée, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS no. 6612 – sequence: 5 givenname: T surname: Cuisset fullname: Cuisset, T organization: Faculté de Médecine, INSERM U626, Université de la Méditerranée, Department of Cardiology, CHU Timone – sequence: 6 givenname: S surname: Boullu fullname: Boullu, S organization: Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Faculté de Médecine, INSERM U626, Université de la Méditerranée, Centre d'Investigation Clinique, CHU Nord – sequence: 7 givenname: F surname: Dadoun fullname: Dadoun, F organization: Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Faculté de Médecine, INSERM U626, Université de la Méditerranée – sequence: 8 givenname: M-C surname: Alessi fullname: Alessi, M-C organization: Faculté de Médecine, INSERM U626, Université de la Méditerranée – sequence: 9 givenname: P surname: Morange fullname: Morange, P organization: Faculté de Médecine, INSERM U626, Université de la Méditerranée – sequence: 10 givenname: K surname: Clément fullname: Clément, K organization: INSERM U872 – sequence: 11 givenname: M surname: Bernard fullname: Bernard, M organization: Université de la Méditerranée, Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS no. 6612 – sequence: 12 givenname: A surname: Dutour fullname: Dutour, A organization: Department of Endocrinology, Metabolic Diseases and Nutrition, CHU Nord, Faculté de Médecine, INSERM U626, Université de la Méditerranée, Centre d'Investigation Clinique, CHU Nord |
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| ContentType | Journal Article |
| Copyright | Macmillan Publishers Limited 2012 2015 INIST-CNRS COPYRIGHT 2012 Nature Publishing Group Copyright Nature Publishing Group Mar 2012 |
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| DOI | 10.1038/ijo.2011.117 |
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| Keywords | cardiovascular magnetic resonance imaging cardiac steatosis epicardial fat myocardial triglyceride content proton magnetic resonance spectroscopy Heart Cardiac performance Lipids NMR spectrometry Proton Nutritional status Visceral fat Human Obesity Nutrition Nutrition disorder Metabolic diseases Fat content Metabolism Triglyceride Nuclear magnetic resonance imaging Steatosis Volume Fat Myocardium Medical imagery Circulatory system |
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To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether... To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether ectopic fat... Objective: To assess epicardial fat volume (EFV), myocardial TG content (MTGC) and metabolic profile in severely obese patients, and to determine whether... International Journal of Obesity (2012) 36, 422- 430; doi:10.1038/ijo.2011.117;published online 5 July 2011 |
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| SubjectTerms | Adult Biological and medical sciences Blood glucose Body mass Body mass index Cardiac function Cardiomyopathy Cardiorespiratory Cardiovascular disease Coronary vessels Diabetes Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology Diagnosis Epidemiology Evaluation Fat Female Health Promotion and Disease Prevention Heart Humans Insulin Insulin resistance Internal Medicine Intra-Abdominal Fat - metabolism Intra-Abdominal Fat - pathology Ischemia Lipid Metabolism Lipids Magnetic resonance imaging Magnetic Resonance Spectroscopy Male Measurement Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolism Metabolome Obesity Obesity, Morbid - complications Obesity, Morbid - metabolism Obesity, Morbid - physiopathology original-article Patients Pericardium - metabolism Pericardium - pathology Physiological aspects Public Health Research design Risk factors Spectroscopy Spectrum analysis Triglycerides Triglycerides - metabolism Vein & artery diseases Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - metabolism Ventricular Dysfunction, Left - physiopathology |
| Title | Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat |
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