Mitogenicity and Adjuvanticity of Lipopolysaccharide from a Marine Bacterium, Vibrio anguillarum, in Mice

The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A, B, and C) strains of Vibrio anguillarum on the murine immune response were studied. Although the LPSs lack 2-keto-3-deoxyoctonate (KDO) and the sugar compositions of their core regions are markedly different, depending on t...

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Published inChemical & pharmaceutical bulletin Vol. 32; no. 10; pp. 4165 - 4169
Main Authors KONDO, SEIICHI, HISATSUNE, KAZUHITO, SHIMIZU, TADAYORI, IGUCHI, TAKEHIRO, MATSUSAKA, EIICHIRO, MASUZAWA, TOSHIYUKI, YANAGIHARA, YASUTAKE, MIFUCHI, ICHIJI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1984
公益社団法人日本薬学会
Maruzen
Subjects
2-keto-3-deoxyoctonate
adjuvanticity
Adjuvants, Immunologic
Animals
Biological and medical sciences
Female
General pharmacology
lipopolysaccharide
Male
Marine
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
mitogenicity
Mitogens
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Polysaccharides, Bacterial - pharmacology
Vibrio - immunology
Vibrio anguillarum
Marine environment
Lipopolysaccharide
Bacteria
Immunostimulant agent
Mitogen
Structure activity relation
Online AccessGet full text
ISSN0009-2363
1347-5223
DOI10.1248/cpb.32.4165

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Abstract The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A, B, and C) strains of Vibrio anguillarum on the murine immune response were studied. Although the LPSs lack 2-keto-3-deoxyoctonate (KDO) and the sugar compositions of their core regions are markedly different, depending on the O-serotype, they were all able to induce a mitogenic effect on in vitro-cultured spleen cells of C57BL/6 mice. The LPS was capable of increasing the incorporation of 3H-thymidine into spleen cells that had been treated with rabbit antithymocyte serum in the presence of complement in order to kill T-lymphocytes. When sheep erythrocytes and LPS were injected intraperitoneally into BALB/c mice, the LPSs exhibited an enhancing effect on the antibody response regardless of the serotype. These findings suggest that these biological effects of V. anguillarum LPSs from different O-serotype strains are little affected by the absence of KDO and the differences in sugar composition.
AbstractList The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A, B, and C) strains of Vibrio anguillarum on the murine immune response were studied. Although the LPSs lack 2-keto-3-deoxyoctonate (KDO) and the sugar compositions of their core regions are markedly different, depending on the O-serotype, they were all able to induce a mitogenic effect on in vitro-cultured spleen cells of C57BL/6 mice. The LPS was capable of increasing the incorporation of 3H-thymidine into spleen cells that had been treated with rabbit antithymocyte serum in the presence of complement in order to kill T-lymphocytes. When sheep erythrocytes and LPS were injected intraperitoneally into BALB/c mice, the LPSs exhibited an enhancing effect on the antibody response regardless of the serotype. These findings suggest that these biological effects of V. anguillarum LPSs from different O-serotype strains are little affected by the absence of KDO and the differences in sugar composition.
The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A,B, and C) strains of V. anguillarum on the murine immune response were studied. Although the LPSs lack 2-keto-3-deoxyoctonate (KDO) and the sugar compositions of their core regions are markedly different, depending on the O-serotype, they were all able to induce a mitogenic effect on in vitro-cultured spleen cells of C57BL/6 mice. The LPS was capable of increasing the incorporation of super(3)H-thymidine into spleen cells that had been treated with rabbit antithymocyte serum in the presence of complement in order to kill T-lymphocytes. When sheep erythrocytes and LPS were injected intraperitoneally into BALB/c mice, the LPSs exhibited an enhancing effect on the antibody response regardless of the serotype. These findings suggest that these biological effects of V. anguillarum) LPSs from different O-serotype strains are little affected by the absence of KDO and the differences in sugar composition.
Author HISATSUNE, KAZUHITO
MIFUCHI, ICHIJI
MASUZAWA, TOSHIYUKI
MATSUSAKA, EIICHIRO
SHIMIZU, TADAYORI
YANAGIHARA, YASUTAKE
IGUCHI, TAKEHIRO
KONDO, SEIICHI
Author_FL HISATSUNE KAZUHITO
YANAGIHARA YASUTAKE
KONDO SEIICHI
SHIMIZU TADAYORI
MATSUSAKA EIICHIRO
MIFUCHI ICHIJI
IGUCHI TAKEHIRO
MASUZAWA TOSHIYUKI
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Keywords Marine environment
Lipopolysaccharide
Bacteria
Immunostimulant agent
Mitogen
Structure activity relation
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References_xml – reference: 8) J. G. Gray, A. P. Monaco, M. L. Wood, and P. S. Russell, J. Immunol., 96, 217 (1966).
– reference: 4) I. Mifuchi, Y. Yanagihara, T. Shimizu, and M. Ushiyama, Fish Pathol., 18, 29 (1983).
– reference: 17) D. C. Morrison and J. L. Ryan, Adv. Immunol., 28, 293 (1979).
– reference: 15) K. Hisatsune, S. Kondo, T. Iguchi, M. Machida, S. Asou, M. Inaguma, and F. Yamamoto, Microbiol. Immunol., 26, 649 (1982); G. D. F. Jackson and J. W. Redmond, FEBS Lett., 13, 117 (1971).
– reference: T. Kuwae and M. Kurata, Microbiol. Immunol., 27, 137 (1983).
– reference: 3) K. Hisatsune, T. Iguchi, S. Kondo, M. Inaguma, T. Shimizu, Y. Yanagihara, and I. Mifuchi, Jpn. J. Bacteriol., 36, 351 (1981).
– reference: K. Muroga, J. Fac. Fish. Anim. Hus. Hiroshima Univ., 14, 101 (1975).
– reference: A. Nowotny, U. H. Behling, and H. L. Chang, J. Immunol., 115, 199 (1975).
– reference: 18) M. Nakano, M. J. Tanabe, H. Hori, S. Kondo, and K. Hisatsune, Microbiol. Immunol., 21, 611 (1977);
– reference: ed. by B. Amos, and H. Koprowski, Wistar Inst. Press, Philadelphia, 1963, pp. 109-122.
– reference: 14) Y. Yanagihara, T. Shimizu, A. Takagi, and I. Mifuchi, Microbiol. Immunol., 28, 499 (1984).
– reference: 13) T. Shimizu and I. Mifuchi, Yakugaku Zasshi, 103, 761 (1983).
– reference: 1) T. Aoki and T. Kitao, Fish Pathol., 13,19 (1978);
– reference: 6) J. Andersson, O. Sjöberg, and G. Moller, Transplant. Rev., 11, 131 (1972).
– reference: 7) J. D. Stobo, Transplant. Rev., 11, 60 (1972).
– reference: 2) T. Shimizu, M. Nitta, Y. Itoh, Y. Yanagihara, and I. Mifuchi, Microbiol. Immunol., 25, 929 (1981).
– reference: 10) N. K. Jerne, A. Nordin, and C. Henry, "Cell-Bound Antibodies,"
– reference: 11) T. Shimizu, M. Nitta, and I. Mifuchi, Gann, 70, 429 (1979).
– reference: 5) O.Westphal, O. Lüderitz, and F. Bister, Z. Naturforsh., 7b, 148 (1952).
– reference: 9) E. A. Boyse, L. J. Old, and G. Thomas, Transplant. Rev., 29, 63 (1962).
– reference: 12) T. Shimizu, Y. Itoh, I. Mifuchi, T. Iguchi, S. Kondo, and K. Hisatsune, Gann, 74, 279 (1983).
– reference: 16) S. Frank, S. Specter, A. Nowotny, and H. Friedman, J. Immunol., 119, 855 (1977);
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Snippet The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A, B, and C) strains of Vibrio anguillarum on the murine immune response were...
The effects of lipopolysaccharides (LPS) extracted from three O-serotype (A,B, and C) strains of V. anguillarum on the murine immune response were studied....
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SubjectTerms 2-keto-3-deoxyoctonate
adjuvanticity
Adjuvants, Immunologic
Animals
Biological and medical sciences
Female
General pharmacology
lipopolysaccharide
Male
Marine
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
mitogenicity
Mitogens
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Polysaccharides, Bacterial - pharmacology
Vibrio - immunology
Vibrio anguillarum
Title Mitogenicity and Adjuvanticity of Lipopolysaccharide from a Marine Bacterium, Vibrio anguillarum, in Mice
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