The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization
ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have...
Saved in:
Published in | Oncogene Vol. 23; no. 56; pp. 9007 - 9016 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
02.12.2004
Nature Publishing Nature Publishing Group |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a longer form of iASPP(RAI), which at 828 amino acids is more than twice the size of iASPP(RAI). Using two antibodies that recognize both iASPP and iASPP(RAI), we report that this longer form of iASPP is the predominant form of the molecule expressed in cells. Like iASPP(RAI), iASPP also binds to p53 and inhibits apoptosis induced by p53 overexpression. However, whereas iASPP(RAI) is predominantly nuclear, the N-terminus of iASPP is entirely cytoplasmic, and the longer iASPP is located in both the cytoplasm and the nucleus. The effect upon subcellular localization of the longer N-terminus of iASPP means that this new, longer form of the molecule may be subject to greater regulation and provides another layer in the control of p53-induced apoptosis. |
---|---|
AbstractList | ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic p53-responsive genes. iASPP(RAI) is a third member of the family that is the most conserved inhibitor of p53-mediated apoptosis. Here, we have described iASPP, a longer form of iASPP(RAI), which at 828 amino acids is more than twice the size of iASPP(RAI). Using two antibodies that recognize both iASPP and iASPP(RAI), we report that this longer form of iASPP is the predominant form of the molecule expressed in cells. Like iASPP(RAI), iASPP also binds to p53 and inhibits apoptosis induced by p53 overexpression. However, whereas iASPP(RAI) is predominantly nuclear, the N-terminus of iASPP is entirely cytoplasmic, and the longer iASPP is located in both the cytoplasm and the nucleus. The effect upon subcellular localization of the longer N-terminus of iASPP means that this new, longer form of the molecule may be subject to greater regulation and provides another layer in the control of p53-induced apoptosis. |
Audience | Academic |
Author | Slee, Elizabeth A Ali, Safia Llanos, Susana Royer, Christophe Bergamaschi, Daniele Trigiante, Giuseppe Lu, Xin Gillotin, Sébastien Jin, Boquan |
Author_xml | – sequence: 1 givenname: Elizabeth A surname: Slee fullname: Slee, Elizabeth A organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Ludwig Institute for Cancer Research, University College London – sequence: 2 givenname: Sébastien surname: Gillotin fullname: Gillotin, Sébastien organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Ludwig Institute for Cancer Research, University College London – sequence: 3 givenname: Daniele surname: Bergamaschi fullname: Bergamaschi, Daniele organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Ludwig Institute for Cancer Research, University College London – sequence: 4 givenname: Christophe surname: Royer fullname: Royer, Christophe organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Ludwig Institute for Cancer Research, University College London – sequence: 5 givenname: Susana surname: Llanos fullname: Llanos, Susana organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine – sequence: 6 givenname: Safia surname: Ali fullname: Ali, Safia organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine – sequence: 7 givenname: Boquan surname: Jin fullname: Jin, Boquan organization: Department of Immunology, Fourth Military Medical University – sequence: 8 givenname: Giuseppe surname: Trigiante fullname: Trigiante, Giuseppe organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine – sequence: 9 givenname: Xin surname: Lu fullname: Lu, Xin email: x.lu@imperial.ac.uk organization: Ludwig Institute for Cancer Research, Imperial College School of Medicine, Ludwig Institute for Cancer Research, University College London |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16322373$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/15489900$$D View this record in MEDLINE/PubMed |
BookMark | eNqFkdtrFDEUxoNU7Lb66psSKvo229wml8eleIOiBeujhGwmabPMJNtkRqh_vVl2YEAokoeEc37nO-fkOwMnMUUHwGuM1hhReVl26xTtGhMkkZTPwAozwZu2VewErJBqUaMIJafgrJQdQkgoRF6AU9wyqRRCK_Dr9t7Bb83o8hDiVGDy0MCYfrsehpJ8ysMhdD8NJsKw-XFzU8Mwu4cpZNfBmodhLNA-jmnfmzIEC_tkTR_-mDGk-BI896Yv7tV8n4Ofnz7eXn1prr9__nq1uW4sx3xsWkqk6hQVHe0Q8hZ7TL00HTKGbH3LsRSeKMqZYB2jinuDGDVbSjrCBavvc_DhqLvP6WFyZdRDKNb1vYkuTUVzgVvJFPoviEXVa5Go4Lt_wF2acqxLaMIZpnUKcaAunqSIoC2mWFVofYTuTO90iD6N2dh6Olf_q9rpQ41vsFRICC74UmBzKiU7r_c5DCY_aoz0wXVddrq6rmfXa8HbeYxpO7huwWebK_B-Bkyp7vhsog1l4TglhApaucsjV2oq3rm87PNk6zfHimjGKbtFcs7_BTvTzg8 |
CODEN | ONCNES |
CitedBy_id | crossref_primary_10_1016_j_jmb_2007_03_001 crossref_primary_10_1016_j_canlet_2014_10_044 crossref_primary_10_1038_sj_cdd_4401924 crossref_primary_10_1097_MD_0000000000006640 crossref_primary_10_1371_journal_pone_0094175 crossref_primary_10_18632_oncotarget_6478 crossref_primary_10_1007_s10555_015_9556_2 crossref_primary_10_1128_JVI_01072_15 crossref_primary_10_1172_JCI28920 crossref_primary_10_1016_j_febslet_2014_05_008 crossref_primary_10_1038_s41418_017_0039_6 crossref_primary_10_1096_fj_13_244632 crossref_primary_10_1016_j_leukres_2009_02_016 crossref_primary_10_1038_sj_onc_1209341 crossref_primary_10_1021_acschembio_2c00177 crossref_primary_10_1038_nrc1818 crossref_primary_10_1016_j_bbcan_2005_08_002 crossref_primary_10_1016_j_ccr_2013_03_013 crossref_primary_10_1111_j_1349_7006_2007_00723_x crossref_primary_10_1016_j_febslet_2011_04_012 crossref_primary_10_18632_oncotarget_4847 crossref_primary_10_1016_j_jid_2019_01_020 crossref_primary_10_1016_j_cell_2014_05_006 crossref_primary_10_1038_ng1879 crossref_primary_10_1016_j_str_2007_11_012 crossref_primary_10_1016_j_matbio_2016_10_001 crossref_primary_10_1038_nrm_2016_41 crossref_primary_10_1039_C8SC03390K crossref_primary_10_1007_s12032_012_0306_9 crossref_primary_10_1016_j_jmb_2007_05_024 crossref_primary_10_1016_j_yexcr_2007_05_006 crossref_primary_10_1002_chem_202000465 crossref_primary_10_1038_cdd_2010_101 crossref_primary_10_1038_sj_cdd_4401575 crossref_primary_10_1074_jbc_M111_270751 crossref_primary_10_1016_j_leukres_2009_04_037 crossref_primary_10_1186_1475_2867_13_116 crossref_primary_10_1016_j_bbrc_2012_06_124 crossref_primary_10_1073_pnas_1201514110 crossref_primary_10_1002_iub_392 crossref_primary_10_1038_s41419_023_05567_9 crossref_primary_10_1038_cddis_2014_442 crossref_primary_10_1016_j_plasmid_2009_01_004 crossref_primary_10_1016_j_celrep_2022_111503 crossref_primary_10_7314_APJCP_2012_13_5_1727 crossref_primary_10_1038_srep11629 |
Cites_doi | 10.1126/science.1068999 10.1126/science.274.5289.1001 10.1038/ng1070 10.1101/gad.11.14.1840 10.1038/35042675 10.1038/nrc864 10.1073/pnas.91.13.6098 10.1128/MCB.24.3.1341-1350.2004 10.1128/MCB.16.7.3884 10.1016/S0960-9822(01)00534-6 10.1074/jbc.274.22.15662 10.1128/MCB.18.5.2524 10.1016/S1097-2765(03)00050-9 10.1016/S1097-2765(01)00367-7 10.1016/S0378-4274(02)00421-6 10.1126/science.1065486 10.1074/jbc.M004359200 10.1038/sj.onc.1207516 |
ContentType | Journal Article |
Copyright | Springer Nature Limited 2004 2005 INIST-CNRS COPYRIGHT 2004 Nature Publishing Group Copyright Nature Publishing Group Dec 2, 2004 Nature Publishing Group 2004. |
Copyright_xml | – notice: Springer Nature Limited 2004 – notice: 2005 INIST-CNRS – notice: COPYRIGHT 2004 Nature Publishing Group – notice: Copyright Nature Publishing Group Dec 2, 2004 – notice: Nature Publishing Group 2004. |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7TM 7TO 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M7P MBDVC P64 PQEST PQQKQ PQUKI PRINS Q9U RC3 7X8 |
DOI | 10.1038/sj.onc.1208088 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database (Proquest) Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central ProQuest Central Essentials Biological Science Collection ProQuest Central ProQuest Natural Science Collection ProQuest One Community College ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts Technology Research Database ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic Oncogenes and Growth Factors Abstracts Research Library Prep Research Library Prep |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Biology |
EISSN | 1476-5594 |
EndPage | 9016 |
ExternalDocumentID | 978762291 A189077676 10_1038_sj_onc_1208088 15489900 16322373 1208088 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | - -Q- 0R 123 1AW 29N 2WC 39C 3O- 3V. 4.4 53G 55 5RE 7X7 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AADWK AAPBV AAYJO AAZLF ABAWZ ABDBF ABEFU ABFLS ABGIJ ABPTK ABUWG ACGFS ACKTT ACPRK ADBBV ADBIT ADHDB ADQMX AEDAW AEJRE AENEX AEXYK AFFNX AFKRA AFSHS AGEZK AHGBK AHMBA AHSBF AJRNO ALFFA ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF AXYYD AZFZN AZQEC B0M BAWUL BBAFP BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CAG COF CS3 DIK DU5 DWQXO E3Z EAD EAP EBC EBD EBLON EBS EE. EIOEI EJD EMB EMK EPL ESX F5P FDQFY FEDTE FERAY FIZPM FRP FSGXE FYUFA GNUQQ GUQSH HCIFZ HVGLF HZ IAO IHR INH INR IPNFZ ITC JSO KQ8 L7B LK8 M0L M1P M2O M7P N9A NAO O9- OK1 OVD P2P PADUT PQEST PQQKQ PQUKI PRINS PROAC PSQYO Q- Q2X RIG RNS RNT RNTTT SNX SNYQT SV3 SWTZT TAOOD TBHMF TDRGL TR2 TSG TUS UDS W2D WH7 X7M ZA5 --- .55 0R~ 36B 406 AANZL AAWBL AAYZH ABAKF ABJNI ABLJU ABZZP ACAOD ACGFO ACMJI ACRQY ACZOJ ADFRT AEMSY AEVLU AFBBN AGHAI AGQEE ALIPV AMYLF CCPQU DNIVK DPUIP EMOBN HMCUK HZ~ IWAJR JZLTJ NQJWS NXXTH SOHCF SRMVM TEORI UKHRP ~8M .GJ 08R 70F AATNV AAUGY AAYFA ACBMV ACBRV ACBYP ACIGE ACTTH ACVWB ADMDM ADYYL AEFTE AFNRJ AGGBP AILAN AJCLW AJDOV AMRJV IQODW NYICJ ZXP CGR CUY CVF ECM EIF NPM AAYXX CITATION 7TM 7TO 7U9 7XB 8FD 8FK FR3 H94 K9. MBDVC P64 Q9U RC3 7X8 |
ID | FETCH-LOGICAL-c616t-53289d937d3d00fc1f13f8ad0aa2bf56187f2936474d4396fa043ab32d2674043 |
IEDL.DBID | 8C1 |
ISSN | 0950-9232 |
IngestDate | Fri Oct 25 11:24:55 EDT 2024 Thu Oct 24 22:44:34 EDT 2024 Wed Nov 06 08:20:15 EST 2024 Mon Nov 04 11:38:47 EST 2024 Wed Nov 13 00:21:35 EST 2024 Fri Nov 22 00:27:44 EST 2024 Tue Oct 15 23:30:05 EDT 2024 Sun Oct 22 16:06:18 EDT 2023 Thu Dec 12 04:11:00 EST 2024 Tue Jun 15 14:09:03 EDT 2021 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 56 |
Keywords | apoptosis iASPP p53 Human Molecular form TP53 Gene Localization Carcinogenesis Apoptosis Tumor suppressor gene |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c616t-53289d937d3d00fc1f13f8ad0aa2bf56187f2936474d4396fa043ab32d2674043 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | http://dx.doi.org/10.1038/sj.onc.1208088 |
PMID | 15489900 |
PQID | 227351319 |
PQPubID | 36330 |
PageCount | 10 |
ParticipantIDs | proquest_miscellaneous_67158490 proquest_miscellaneous_17740507 proquest_journals_2641339677 proquest_journals_227351319 gale_infotracacademiconefile_A189077676 crossref_primary_10_1038_sj_onc_1208088 pubmed_primary_15489900 pascalfrancis_primary_16322373 springer_journals_10_1038_sj_onc_1208088 nature_primary_1208088 |
ProviderPackageCode | AEDAW AAZLF -Q- AADWK AAYJO ADQMX EE. RNTTT SWTZT ABGIJ RNT AHGBK NAO |
PublicationCentury | 2000 |
PublicationDate | 2004-12-02 |
PublicationDateYYYYMMDD | 2004-12-02 |
PublicationDate_xml | – month: 12 year: 2004 text: 2004-12-02 day: 02 |
PublicationDecade | 2000 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: Basingstoke – name: England – name: New York |
PublicationTitle | Oncogene |
PublicationTitleAbbrev | Oncogene |
PublicationTitleAlternate | Oncogene |
PublicationYear | 2004 |
Publisher | Nature Publishing Group UK Nature Publishing Nature Publishing Group |
Publisher_xml | – sequence: 0 name: Nature Publishing Group UK – name: Nature Publishing – name: Nature Publishing Group |
References | Slee, EA, Lu, X 2003; 139 Vousden, KH, Lu, X 2002; 2 Bergamaschi, D, Samuels, Y, O'Neil, NJ, Trigiante, G, Crook, T, Hsieh, J-K, O'Connor, DJ, Zhong, S, Campargue, I, Tomlinson, ML, Kuwabara, PE, Lu, X 2003; 33 Samuels-Lev, Y, O'Connor, DJ, Bergamaschi, D, Trigiante, G, Hsieh, JK, Zhong, S, Campargue, I, Naumovski, L, Crook, T, Lu, X 2001; 8 Schumacher, B, Hofmann, K, Boulton, S, Gartner, A 2001; 11 Iwabuchi, K, Bartel, PL, Li, B, Marraccino, R, Fields, S 1994; 91 Hsieh, J-K, Fredersdorf, S, Kouzarides, T, Martin, K, Lu, X 1997; 11 Mihara, M, Erster, S, Zaika, A, Petrenko, O, Chittenden, T, Pancoska, P, Moll, UM 2003; 11 Derry, WB, Putzke, AP, Rothman, JH 2001; 294 Brummelkamp, TR, Bernards, R, Agami, R 2002; 296 Yap, DB, Hsieh, JK, Lu, X 2000; 275 Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X 2004; 24 Gorina, S, Pavletich, NP 1996; 274 Yang, J-P, Hori, M, Sanda, T, Okamoto, T 1999; 274 Naumovski, L, Cleary, ML 1996; 16 Sachdev, S, Hoffmann, A, Hannink, M 1998; 18 Slee, EA, O'Connor, DJ, Lu, X 2004; 23 Vogelstein, B, Lane, D, Levine, AJ 2000; 408 BF1208088_CR6 BF1208088_CR5 BF1208088_CR4 BF1208088_CR11 BF1208088_CR3 BF1208088_CR10 BF1208088_CR13 BF1208088_CR9 BF1208088_CR12 BF1208088_CR8 BF1208088_CR15 BF1208088_CR7 BF1208088_CR14 BF1208088_CR2 BF1208088_CR1 BF1208088_CR17 BF1208088_CR16 BF1208088_CR18 |
References_xml | – volume: 33 start-page: 162 year: 2003 end-page: 167 publication-title: Nat. Genet. contributor: fullname: Lu, X – volume: 294 start-page: 591 year: 2001 end-page: 595 publication-title: Science contributor: fullname: Rothman, JH – volume: 11 start-page: 1722 year: 2001 end-page: 1727 publication-title: Curr. Biol. contributor: fullname: Gartner, A – volume: 2 start-page: 594 year: 2002 end-page: 604 publication-title: Nat. Rev. Cancer contributor: fullname: Lu, X – volume: 275 start-page: 37296 year: 2000 end-page: 37302 publication-title: J. Biol. Chem. contributor: fullname: Lu, X – volume: 296 start-page: 550 year: 2002 end-page: 553 publication-title: Science contributor: fullname: Agami, R – volume: 8 start-page: 781 year: 2001 end-page: 794 publication-title: Mol. Cell contributor: fullname: Lu, X – volume: 11 start-page: 577 year: 2003 end-page: 590 publication-title: Mol. Cell contributor: fullname: Moll, UM – volume: 16 start-page: 3884 year: 1996 end-page: 3892 publication-title: Mol. Cell. Biol. contributor: fullname: Cleary, ML – volume: 274 start-page: 15662 year: 1999 end-page: 15670 publication-title: J. Biol. Chem. contributor: fullname: Okamoto, T – volume: 24 start-page: 1341 year: 2004 end-page: 1350 publication-title: Mol. Cell. Biol. contributor: fullname: Lu, X – volume: 23 start-page: 2809 year: 2004 end-page: 2818 publication-title: Oncogene contributor: fullname: Lu, X – volume: 91 start-page: 6098 year: 1994 end-page: 6102 publication-title: Proc. Natl. Acad. Sci. USA contributor: fullname: Fields, S – volume: 408 start-page: 307 year: 2000 end-page: 310 publication-title: Nature contributor: fullname: Levine, AJ – volume: 11 start-page: 1840 year: 1997 end-page: 1852 publication-title: Genes Dev. contributor: fullname: Lu, X – volume: 18 start-page: 2524 year: 1998 end-page: 2534 publication-title: Mol. Cell. Biol. contributor: fullname: Hannink, M – volume: 139 start-page: 81 year: 2003 end-page: 87 publication-title: Tox. Lett. contributor: fullname: Lu, X – volume: 274 start-page: 1001 year: 1996 end-page: 1005 publication-title: Science contributor: fullname: Pavletich, NP – ident: BF1208088_CR3 doi: 10.1126/science.1068999 – ident: BF1208088_CR5 doi: 10.1126/science.274.5289.1001 – ident: BF1208088_CR2 doi: 10.1038/ng1070 – ident: BF1208088_CR6 doi: 10.1101/gad.11.14.1840 – ident: BF1208088_CR15 doi: 10.1038/35042675 – ident: BF1208088_CR16 doi: 10.1038/nrc864 – ident: BF1208088_CR7 doi: 10.1073/pnas.91.13.6098 – ident: BF1208088_CR1 doi: 10.1128/MCB.24.3.1341-1350.2004 – ident: BF1208088_CR9 doi: 10.1128/MCB.16.7.3884 – ident: BF1208088_CR12 doi: 10.1016/S0960-9822(01)00534-6 – ident: BF1208088_CR17 doi: 10.1074/jbc.274.22.15662 – ident: BF1208088_CR10 doi: 10.1128/MCB.18.5.2524 – ident: BF1208088_CR8 doi: 10.1016/S1097-2765(03)00050-9 – ident: BF1208088_CR11 doi: 10.1016/S1097-2765(01)00367-7 – ident: BF1208088_CR13 doi: 10.1016/S0378-4274(02)00421-6 – ident: BF1208088_CR4 doi: 10.1126/science.1065486 – ident: BF1208088_CR18 doi: 10.1074/jbc.M004359200 – ident: BF1208088_CR14 doi: 10.1038/sj.onc.1207516 |
SSID | ssj0007902 |
Score | 2.07834 |
Snippet | ASPP1 and ASPP2 are both proteins that interact with p53 and enhance its ability to induce apoptosis by selectively elevating the expression of proapoptotic... |
SourceID | proquest gale crossref pubmed pascalfrancis springer nature |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 9007 |
SubjectTerms | Adaptor Proteins, Signal Transducing Ageing, cell death Amino Acid Sequence Amino acids Apoptosis Apoptosis - physiology Apoptosis Regulatory Proteins Base Sequence Biological and medical sciences Cancer research Carrier Proteins - chemistry Carrier Proteins - metabolism Cell Biology Cell cycle Cell death Cell division Cell Line, Tumor Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cytoplasm Cytoplasm - metabolism DNA damage DNA Primers Fundamental and applied biological sciences. Psychology Human Genetics Humans Internal Medicine Localization Medical research Medicine Medicine & Public Health Molecular and cellular biology Molecular Sequence Data N-Terminus Nematodes Oncology original-paper p53 Protein Protein Isoforms - chemistry Protein Isoforms - metabolism Proteins Sequence Homology, Amino Acid Tumor Suppressor Protein p53 - metabolism Tumor Suppressor Protein p53 - physiology |
Title | The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization |
URI | http://dx.doi.org/10.1038/sj.onc.1208088 https://link.springer.com/article/10.1038/sj.onc.1208088 https://www.ncbi.nlm.nih.gov/pubmed/15489900 https://www.proquest.com/docview/227351319 https://www.proquest.com/docview/2641339677 https://search.proquest.com/docview/17740507 https://search.proquest.com/docview/67158490 |
Volume | 23 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfZ3db9MwEMBPbBMfEkJQGISN4gckeAlzvuz0CZVq04S0qgIm9QVZjj-kTpCUJkXaf885cRohCq-5KE58Z9_P8fkO4I2MCiotZ6FJswwXKKkMJXrxsMgt51ppRqU7nHw1Z5fX6adltvSxObUPq-znxHai1pVy_8jPYvSzWYQG82H9M3RFo9zmqq-gcQBHkfNz7qD4bIjw4F3IIUIEDZFj4j5nY5Kf1TfvKxx_UYzA1BZdGXySn5l3iTUfrmWN3WW7Ohf7QPSvTdTWN108hkceKsm0s4IncMeUI7jblZm8HcH9WV_VbQT3rvxm-lP4hiZC5mEXDrOtSWWJJGX1y3wnq7pyMOsutUX8yGr6ZbHAy2RjXOiw0QTlZNXURN021RoR_MdKkdYx-oOdz-D64vzr7DL01RZCxSLWhFmCay-NtKITTalVkY0Sm0tNpYwLi5iVc4tswFKeaqQYZiVNE1kksY4Zdzl6juGwrErzAsgkRu6QiAK4lkonPCqU4nGujVFJLLPJJIC3fX-LdZdUQ7Sb4Uku6huBmhFeM3inU4dwo63ZSCX9oQFsx-WtElNso01IxAI47jQ2PLF_xPgPDQ5yhpNZwpMATnqVCj-Aa7EztwBO90gZ-n7sA84DeL0ToybdbossTbWtRYRgTZG2_30H4xHi34QG8LwzpOHVcB2JmICSd71lDY3v76mX__2KE3jQZ6ik8SkcNputeYU01RRjOOBLPm5HzhiOPp7PF59_A77kHN8 |
link.rule.ids | 314,780,784,12056,12223,21388,27924,27925,31719,31720,33266,33267,33744,33745,43310,43579,43805,73745,74014,74302 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJxgSQlDYCBubH5DgJcz5spMnVKZNBdaqgk3aC7Ic25E6QdI1KdL-e86J0wpRePVFdnJ3vvs5d74DeCODnMqCM9_ESYIHlFj6Er24n6cF51ppRqW9nDyZsvFV_Pk6uXa5ObVLq-xtYmuodaXsP_KTEP1sEqDCfFjc-rZplA2uug4a92HHFk5PBrDz8Ww6-7o2xbxLOkQYQX1EMmFftTFKT-qb9xXuwCBEyNS2Xdl4JWeb16U1Hy9kjQwruk4X26DoX2HU1judP4UnDlaSUacHz-CeKYfwoGs0eTeE3dO-r9sQHk5cOP05fEclIVO_S4hZ1aQqiCRl9cv8IPO6snDWDrVt_Mh89G02w2GyNDZ52GiCdDJvaqLummqBIPznXJHWNbqrnS_g6vzs8nTsu34LvmIBa_wkwtOXRryiI01poYIiiIpUaiplmBcItFJeIDpgMY814hhWSBpHMo9CHTJuq_TswaCsSvMSSBYi8pAIBvA0FWc8yJXiYaqNUVEokyzz4G3Pb7HoymqINhwepaK-ESgZ4SSDT1pxCLvfmqVU0l0bwHVs5SoxwjXakkTMg71OYpsZ-ymO_pDghs7QnEU88uCgF6lwW7gWa4Xz4HALlaH3Rx5w7sHxmoyStPEWWZpqVYsAoTVFvP3vJxgPEABm1IP9TpE2r4YnSQQKSHnXa9Zm8e2cevXfrziG3fHl5EJcfJp-OYBHfb1KGh7CoFmuzGvEVk1-5HbQb-JCHuw |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9MwED9BJwYSQlDYCBubH5DgJdRxEjt5QmWsGh-rKmDSXibLiWOpE0tKkyLtv-ecOK0QhVdfZCe-r59z5zuAVyrIqDKC-0UUx3hAiZSv0Iv7WWKE0LnmVNnLyedTfnYRfbqML11JodqlVfY2sTXUusrtP_IRQz8bBygwI-OyImYfJu8WP33bQMoGWl03jbuwg06RsgHsvD-dzr6uzbLoEhARUlAfUQ3rKziGyai-fluhNgYM4VPbgmXjoZydXpfZfLhQNW6e6bpebIOlf4VUW081eQyPHMQk404mnsCdohzCva7p5O0Q7p_0Pd6GsHvuQutP4QoFhkz9LjlmVZPKEEXK6lfxg8zrykJbO9S29CPz8bfZDIfJsrCJxIUmSCfzpib5bVMtEJDfzHPSukl3zfMZXExOv5-c-a73gp_zgDd-HOJJTCN20aGm1OSBCUKTKE2VYplB0JUIg0iBRyLSiGm4UTQKVRYyzbiwFXv2YFBWZfEcSMoQhSgEBniyilIRZHkuWKKLIg-ZitPUg9f9fstFV2JDtqHxMJH1tUTOSMcZfNKyQ1rda5YqV-4KAa5jq1jJMa7RlifiHux1HNvM2E9x9AcHN3SOpi0UoQcHPUulU-daroXPg8MtVI5IAPdACA-O12TkpI29qLKoVrUMEGZTxN7_foKLAMFgSj3Y7wRp82p4qkTQgJQ3vWRtFt--Uy_--xXHsIvKI798nH4-gAd96UrKDmHQLFfFS4RZTXbkFOg3iaMjGQ |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+N-terminus+of+a+novel+isoform+of+human+iASPP+is+required+for+its+cytoplasmic+localization&rft.jtitle=Oncogene&rft.au=Slee%2C+Elizabeth+A&rft.au=Gillotin%2C+S%C3%A9bastien&rft.au=Bergamaschi%2C+Daniele&rft.au=Royer%2C+Christophe&rft.date=2004-12-02&rft.issn=0950-9232&rft.volume=23&rft.issue=56&rft.spage=9007&rft.epage=9016&rft_id=info:doi/10.1038%2Fsj.onc.1208088&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0950-9232&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0950-9232&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0950-9232&client=summon |