Pediatric solid tumor genomics and developmental pliancy

Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last 5 years, there have been significant advances in our understanding of the genetic lesions that contribute to the initiation and progression of pediatric solid tumors. To...

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Published in	Oncogene Vol. 34; no. 41; pp. 5207 - 5215
Main Authors	Chen, X, Pappo, A, Dyer, M A
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 08.10.2015 Nature Publishing Group
Subjects	45/23 631/67/69 Apoptosis Cancer Cancer in children Cell Biology Child Development and progression Disease susceptibility Epigenesis, Genetic Gene Expression Regulation, Neoplastic Genes, Neoplasm Genetic aspects Genetic research Genomics Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mutation Neoplasms - genetics Neoplasms - pathology Oncology Oncology, Experimental Pediatrics Review Tumors
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Abstract	Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last 5 years, there have been significant advances in our understanding of the genetic lesions that contribute to the initiation and progression of pediatric solid tumors. To date, over 1000 pediatric solid tumors have been analyzed by Next-Generation Sequencing. These genomic data provide the foundation to launch new research efforts to address one of the fundamental questions in cancer biology—why are some cells more susceptible to malignant transformation by particular genetic lesions at discrete developmental stages than others? Because of their developmental, molecular, cellular and genetic diversity, pediatric solid tumors provide an ideal platform to begin to answer this question. In this review, we highlight the diversity of pediatric solid tumors and provide a new framework for studying the cellular and developmental origins of pediatric cancer. We also introduce a new unifying concept called cellular pliancy as a possible explanation for susceptibility to cancer and the developmental origins of pediatric solid tumors.
AbstractList	Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last 5 years, there have been significant advances in our understanding of the genetic lesions that contribute to the initiation and progression of pediatric solid tumors. To date, over 1000 pediatric solid tumors have been analyzed by Next-Generation Sequencing. These genomic data provide the foundation to launch new research efforts to address one of the fundamental questions in cancer biology--why are some cells more susceptible to malignant transformation by particular genetic lesions at discrete developmental stages than others? Because of their developmental, molecular, cellular and genetic diversity, pediatric solid tumors provide an ideal platform to begin to answer this question. In this review, we highlight the diversity of pediatric solid tumors and provide a new framework for studying the cellular and developmental origins of pediatric cancer. We also introduce a new unifying concept called cellular pliancy as a possible explanation for susceptibility to cancer and the developmental origins of pediatric solid tumors. Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last 5 years, there have been significant advances in our understanding of the genetic lesions that contribute to the initiation and progression of pediatric solid tumors. To date, over 1000 pediatric solid tumors have been analyzed by Next-Generation Sequencing. These genomic data provide the foundation to launch new research efforts to address one of the fundamental questions in cancer biology--why are some cells more susceptible to malignant transformation by particular genetic lesions at discrete developmental stages than others? Because of their developmental, molecular, cellular and genetic diversity, pediatric solid tumors provide an ideal platform to begin to answer this question. In this review, we highlight the diversity of pediatric solid tumors and provide a new framework for studying the cellular and developmental origins of pediatric cancer. We also introduce a new unifying concept called cellular pliancy as a possible explanation for susceptibility to cancer and the developmental origins of pediatric solid tumors. Oncogene (2015) 34, 5207-5215; doi: 10.1038/onc.2014.474; published online 2 February 2015 Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last5 years, there have been signicant advances in our understanding of the genetic lesions that contribute to the initiation and progression of pediatric solid tumors. To date, over 1000 pediatric solid tumors have been analyzed by Next-Generation Sequencing. These genomic data provide the foundation to launch new research efforts to address one of the fundamental questions in cancer biologywhy are some cells more susceptible to malignant transformation by particular genetic lesions at discrete developmental stages than others? Because of their developmental, molecular, cellular and genetic diversity, pediatric solid tumors provide an ideal platform to begin to answer this question. In this review, we highlight the diversity of pediatric solid tumors and provide a new framework for studying the cellular and developmental origins of pediatric cancer. We also introduce a new unifying concept called cellular pliancy as a possible explanation for susceptibility to cancer and the developmental origins of pediatric solid tumors.
Audience	Academic
Author	Pappo, A Chen, X Dyer, M A
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Snippet	Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last 5 years, there have been... Pediatric solid tumors are remarkably diverse in their cellular origins, developmental timing and clinical features. Over the last5 years, there have been...
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SubjectTerms	45/23 631/67/69 Apoptosis Cancer Cancer in children Cell Biology Child Development and progression Disease susceptibility Epigenesis, Genetic Gene Expression Regulation, Neoplastic Genes, Neoplasm Genetic aspects Genetic research Genomics Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mutation Neoplasms - genetics Neoplasms - pathology Oncology Oncology, Experimental Pediatrics Review Tumors
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Title	Pediatric solid tumor genomics and developmental pliancy
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