Loss of BRCA1 or BRCA2 markedly increases the rate of base substitution mutagenesis and has distinct effects on genomic deletions

• Published in: Oncogene Vol. 36; no. 6; pp. 746 - 755
• Main Authors: Zámborszky, J, Szikriszt, B, Gervai, J Z, Pipek, O, Póti, Á, Krzystanek, M, Ribli, D, Szalai-Gindl, J M, Csabai, I, Szallasi, Z, Swanton, C, Richardson, A L, Szüts, D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.02.2017; Nature Publishing Group
• Subjects: 14/1; 14/19; 14/63; 45/23; 45/70; 631/1647/514; 631/67/69; 82/29; Animals; Apoptosis; BRCA mutations; BRCA1 Protein - drug effects; BRCA1 Protein - genetics; BRCA2 Protein - deficiency; BRCA2 Protein - genetics; Cancer; Cancer genetics; Cell Biology; Cell culture; Chickens; DNA sequencing; Female; Genes; Genomics; Genomics - methods; Human Genetics; Humans; Internal Medicine; Male; Medicine; Medicine & Public Health; Methyl compounds; Mutagenesis; Oncology; Original; original-article; Proteins; Risk factors

Loss-of-function mutations in the BRCA1 and BRCA2 genes increase the risk of cancer. Owing to their function in homologous recombination repair, much research has focused on the unstable genomic phenotype of BRCA1/2 mutant cells manifest mainly as large-scale rearrangements. We used whole-genome seq...