Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization

• Published in: International journal of biomedical imaging Vol. 2023; pp. 1 - 15
• Main Authors: Sarrhini, Otman, D’Orléans-Juste, Pedro, Rousseau, Jacques A., Beaudoin, Jean-François, Lecomte, Roger
• Format: Journal Article
• Language: English
• Published: United States Hindawi 15.06.2023; John Wiley & Sons, Inc; Wiley
• Subjects: Algorithms; Blood; Coronary artery; Cost function; Factorization; Fluorine isotopes; Glucose; Glucose metabolism; Medical imaging; Metabolic rate; Metabolism; Methods; Myocardial infarction; Parameter estimation; PET imaging; Physiological aspects; Physiological effects; Physiological factors; Physiology; Positron emission; Positron emission tomography; Tissues; Tomography; Ventricle

We propose an enhanced method to accurately retrieve time-activity curves (TACs) of blood and tissue from dynamic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) cardiac images of mice. The method is noninvasive and consists of using a constrained nonnegative matrix fac...