Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers

Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but...

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Published inInternational forum of allergy & rhinology Vol. 6; no. 9; pp. 956 - 963
Main Authors Mårtensson, Anders, Greiff, Lennart, Lamei, Sepideh S., Lindstedt, Malin, Olofsson, Tobias C., Vasquez, Alejandra, Cervin, Anders
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.09.2016
Wiley Subscription Services, Inc
Subjects
Administration, Intranasal
Adult
Animals
Bacteria
Bacteria - isolation & purification
bacterial interference
bacteriology
Bees - microbiology
bifidobacteria
Biomarkers
Clinical Medicine
Cross-Over Studies
Cytokines
Cytokines - immunology
Double-Blind Method
Ear diseases
Female
Humans
Klinisk medicin
lactobacillus
Lungmedicin och allergi
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Microbiota
Nasal Lavage Fluid - immunology
Nasal Lavage Fluid - microbiology
paranasal sinuses
probiotics
Respiratory Medicine and Allergy
SNOT-22
therapeutics
Young Adult
SNOT-22
bacteriology
bifidobacteria
therapeutics
lactobacillus
paranasal sinuses
bacterial interference
probiotics
Online AccessGet full text
ISSN2042-6976
2042-6984
2042-6984
DOI10.1002/alr.21762

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Abstract Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response. Methods Twenty‐two healthy subjects received a single administration of honeybee LAB in a sham‐controlled, double‐blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids. Results The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein‐1 (MCP‐1), interleukin‐8 (IL‐8), monokine induced by interferon‐γ (MIG), interleukin‐15 (IL‐15), epidermal growth factor (EGF), eotaxin, interferon gamma‐induced protein‐10 (IP‐10), and interleukin‐1 receptor antagonist (IL‐1RA). Conclusion A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
AbstractList Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response.BACKGROUNDLactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response.Twenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids.METHODSTwenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids.The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-γ (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA).RESULTSThe honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-γ (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA).A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.CONCLUSIONA single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response. Methods Twenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids. Results The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-[gamma] (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA). Conclusion A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response. Methods Twenty‐two healthy subjects received a single administration of honeybee LAB in a sham‐controlled, double‐blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids. Results The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein‐1 (MCP‐1), interleukin‐8 (IL‐8), monokine induced by interferon‐γ (MIG), interleukin‐15 (IL‐15), epidermal growth factor (EGF), eotaxin, interferon gamma‐induced protein‐10 (IP‐10), and interleukin‐1 receptor antagonist (IL‐1RA). Conclusion A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
BACKGROUND: Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response. METHODS: Twenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids. RESULTS: The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-γ (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA). CONCLUSION: A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in chronic rhinosinusitis (CRS). Previous studies have examined effects of topical/nasal LAB in children with secretory otitis media, but little is as yet known about their effects on the human nasal airway. The aim of this pilot study was to examine effects on nasal symptoms and commensal bacteria in healthy subjects of nasal administration of a honeybee LAB microbiome; ie, a mixture of 9 Lactobacillus spp. and 4 Bifidobacterium spp. obtained from the honeybee Apis mellifera. Furthermore, we aimed to assess whether or not the honeybee LAB produced a local inflammatory response. Twenty-two healthy subjects received a single administration of honeybee LAB in a sham-controlled, double-blinded, and crossover design. Using questionnaires, microbiological methods, and nasal lavages, they were assessed regarding symptoms, changes to commensal bacteria, and inflammatory products in nasal lavage fluids. The honeybee LAB did not produce any symptoms or other untoward effects. No changes were observed of commensal bacteria by the honeybee LAB, and no inflammatory response was detected (compared to sham); ie, unaffected nasal lavage fluid levels of monocyte chemoattractant protein-1 (MCP-1), interleukin-8 (IL-8), monokine induced by interferon-γ (MIG), interleukin-15 (IL-15), epidermal growth factor (EGF), eotaxin, interferon gamma-induced protein-10 (IP-10), and interleukin-1 receptor antagonist (IL-1RA). A single human nasal administration of a honeybee LAB microbiome is well tolerated. Specifically, it does not affect commensal bacteria and does not produce an inflammatory response.
Author Lindstedt, Malin
Cervin, Anders
Vasquez, Alejandra
Mårtensson, Anders
Greiff, Lennart
Olofsson, Tobias C.
Lamei, Sepideh S.
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  surname: Mårtensson
  fullname: Mårtensson, Anders
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  surname: Greiff
  fullname: Greiff, Lennart
  email: lennart.greiff@skane.se, lennart.greiff@skane.se
  organization: Department of ORL-Head and Neck Surgery, Skåne University Hospital, Lund, Sweden
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  fullname: Cervin, Anders
  organization: Department of ORL-Head and Neck Surgery, Royal Brisbane and Women's Hospital, School of Medicine, University of Queensland, Brisbane, Australia
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Keywords SNOT-22
bacteriology
bifidobacteria
therapeutics
lactobacillus
paranasal sinuses
bacterial interference
probiotics
Language English
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2016 ARS-AAOA, LLC.
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Potential conflict of interest: A.M. has received project‐related financial support from Stig and Ragna Gorthons Foundation. L.G. has received financial support from AstraZeneca, Schering‐Plough, Orexo, HealthCap, Bioglan, and Nares. L.G. is a shareholder in Nares (a company active in the field of allergic rhinitis). A.C. has received financial support from AstraZeneca and Mediplast. The honeybee lactic acid bacterial microbiome used in the study is a patented product of the company ConCellae; A.V. and T.O. are shareholders in ConCellae.
Funding sources for the study: Stig and Ragna Gorthons Foundation.
L.G. and A.C. contributed equally to this work.
Presented orally at the Annual ARS Meeting on September 20, 2014 in Orlando, FL.
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– name: Wiley Subscription Services, Inc
References Medina M, Villena J, Salva S, et al. Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae. Microbiol Immunol. 2008;52:399-409.
Feazel LM, Frank DN, Ramakrishnan VR. Update on bacterial detection methods in chronic rhinosinusitis: implications for clinicians and research scientists. Int Forum Allergy Rhinol. 2011;1:451-459.
Hentschel J, Muller U, Doht F, et al. Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers-evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases. J Immunol Methods. 2014;404:41-51.
Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994;8:1314-1325.
Olofsson TC, Vasquez A. Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera. Curr Microbiol. 2008;57:356-363.
Saffert RT, Cunningham SA, Ihde SM, et al. Comparison of Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometer to BD Phoenix automated microbiology system for identification of gram-negative bacilli. J Clin Microbiol. 2011;49:887-892.
Gueimonde M, Salminen S. New methods for selecting and evaluating probiotics. Dig Liver Dis. 2006;38:S242-S247.
Tubelius P, Stan V, Zachrisson A. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo-controlled study. Environ Health. 2005;4:25.
Olofsson TC, Butler E, Markowicz P, et al. Lactic acid bacterial symbionts in honeybees-an unknown key to honey's antimicrobial and therapeutic activities. Int Wound J. (in press). Epub 2014 Sep 8. doi: 10.1111/iwj.12345.
Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;(23):3 p preceding table of contents, 1-298.
Greiff L, Cervin A, Ahlstrom-Emanuelsson C, et al. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012;13:53.
Abreu NA, Nagalingam NA, Song Y, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med. 2012;4:151ra24.
Roos K, Hakansson EG, Holm S. Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. BMJ. 2001;322:210-212.
Skovbjerg S, Roos K, Holm SE, et al. Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media. Arch Dis Child. 2009;94:92-98.
Sanders ME, Akkermans LM, Haller D, et al. Safety assessment of probiotics for human use. Gut Microbes. 2010;1:164-185.
Zelaya H, Tsukida K, Chiba E, et al. Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions. Int Immunopharmacol. 2014;19:161-173.
Hopkins C, Gillett S, Slack R, et al. Psychometric validity of the 22-item Sinonasal Outcome Test. Clin Otolaryngol. 2009;34:447-454.
Mukerji SS, Pynnonen MA, Kim HM, et al. Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial. Otolaryngol Head Neck Surg. 2009;140:202-208.
Nagalingam NA, Cope EK, Lynch SV. Probiotic strategies for treatment of respiratory diseases. Trends Microbiol. 2013;21:485-492
Tomosada Y, Chiba E, Zelaya H, et al. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunol. 2013;14:40.
Butler E, Alsterfjord M, Olofsson TC, et al. Proteins of novel lactic acid bacteria from Apis mellifera mellifera: an insight into the production of known extra-cellular proteins during microbial stress. BMC Microbiol. 2013;13:235.
Allavena P, Giardina G, Bianchi G, Mantovani A. IL-15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endothelium. J Leukoc Biol. 1997;61:729-735.
Dajotoy T, Andersson P, Bjartell A, et al. Human eosinophils produce the T cell-attracting chemokines MIG and IP-10 upon stimulation with IFN-gamma. J Leukoc Biol. 2004;76:685-691.
Cleland EJ, Drilling A, Bassiouni A, et al. Probiotic manipulation of the chronic rhinosinusitis microbiome. Int Forum Allergy Rhinol. 2014;4:309-314.
Hojsak I, Snovak N, Abdovic S, et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010;29:312-316.
Butler E, Oien RF, Lindholm C, et al. A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens. Int Wound J. (in press). Epub 2014 Sep 8. doi: 10.1111/iwj.12360.
Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010;103:58-68.
Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207-214.
Vasquez A, Forsgren E, Fries I, et al. Symbionts as major modulators of insect health: lactic acid bacteria and honeybees. PLoS One. 2012;7:e33188.
Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN. Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012;122:467-472.
Harata G, He F, Hiruta N, et al. Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses. Lett Appl Microbiol. 2010;50:597-602.
Olofsson TC, Alsterfjord M, Nilson B, et al. Lactobacillus apinorum sp. nov., Lactobacillus mellifer sp. nov., Lactobacillus mellis sp. nov., Lactobacillus melliventris sp. nov., Lactobacillus kimbladii sp. nov., Lactobacillus helsingborgensis sp. nov. and Lactobacillus kullabergensis sp. nov., isolated from the honey stomach of the honeybee Apis mellifera. Int J Syst Evol Microbiol. 2014;64:3109-3119.
2001; 322
2012; 122
1997; 61
2012; 486
2011; 1
2012
2013; 21
2010; 103
2006; 38
2008; 57
2008; 52
2012; 13
2014; 64
2009; 34
2014; 404
2004; 76
1994; 8
2014; 4
2013; 14
2010; 1
2010; 29
2009; 94
2013; 13
2005; 4
2009; 140
2014; 19
2012; 7
2011; 49
2012; 4
2010; 50
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References_xml – reference: Butler E, Alsterfjord M, Olofsson TC, et al. Proteins of novel lactic acid bacteria from Apis mellifera mellifera: an insight into the production of known extra-cellular proteins during microbial stress. BMC Microbiol. 2013;13:235.
– reference: Sanders ME, Akkermans LM, Haller D, et al. Safety assessment of probiotics for human use. Gut Microbes. 2010;1:164-185.
– reference: Olofsson TC, Vasquez A. Detection and identification of a novel lactic acid bacterial flora within the honey stomach of the honeybee Apis mellifera. Curr Microbiol. 2008;57:356-363.
– reference: Vasquez A, Forsgren E, Fries I, et al. Symbionts as major modulators of insect health: lactic acid bacteria and honeybees. PLoS One. 2012;7:e33188.
– reference: Dajotoy T, Andersson P, Bjartell A, et al. Human eosinophils produce the T cell-attracting chemokines MIG and IP-10 upon stimulation with IFN-gamma. J Leukoc Biol. 2004;76:685-691.
– reference: Skovbjerg S, Roos K, Holm SE, et al. Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media. Arch Dis Child. 2009;94:92-98.
– reference: Feazel LM, Frank DN, Ramakrishnan VR. Update on bacterial detection methods in chronic rhinosinusitis: implications for clinicians and research scientists. Int Forum Allergy Rhinol. 2011;1:451-459.
– reference: Tomosada Y, Chiba E, Zelaya H, et al. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunol. 2013;14:40.
– reference: Saffert RT, Cunningham SA, Ihde SM, et al. Comparison of Bruker Biotyper matrix-assisted laser desorption ionization-time of flight mass spectrometer to BD Phoenix automated microbiology system for identification of gram-negative bacilli. J Clin Microbiol. 2011;49:887-892.
– reference: Hojsak I, Snovak N, Abdovic S, et al. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr. 2010;29:312-316.
– reference: Allavena P, Giardina G, Bianchi G, Mantovani A. IL-15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endothelium. J Leukoc Biol. 1997;61:729-735.
– reference: Abreu NA, Nagalingam NA, Song Y, et al. Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis. Sci Transl Med. 2012;4:151ra24.
– reference: Nagalingam NA, Cope EK, Lynch SV. Probiotic strategies for treatment of respiratory diseases. Trends Microbiol. 2013;21:485-492
– reference: Guillemard E, Tondu F, Lacoin F, Schrezenmeir J. Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial. Br J Nutr. 2010;103:58-68.
– reference: Hentschel J, Muller U, Doht F, et al. Influences of nasal lavage collection-, processing- and storage methods on inflammatory markers-evaluation of a method for non-invasive sampling of epithelial lining fluid in cystic fibrosis and other respiratory diseases. J Immunol Methods. 2014;404:41-51.
– reference: Hopkins C, Gillett S, Slack R, et al. Psychometric validity of the 22-item Sinonasal Outcome Test. Clin Otolaryngol. 2009;34:447-454.
– reference: Harata G, He F, Hiruta N, et al. Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses. Lett Appl Microbiol. 2010;50:597-602.
– reference: Olofsson TC, Butler E, Markowicz P, et al. Lactic acid bacterial symbionts in honeybees-an unknown key to honey's antimicrobial and therapeutic activities. Int Wound J. (in press). Epub 2014 Sep 8. doi: 10.1111/iwj.12345.
– reference: Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN. Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012;122:467-472.
– reference: Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486:207-214.
– reference: Olofsson TC, Alsterfjord M, Nilson B, et al. Lactobacillus apinorum sp. nov., Lactobacillus mellifer sp. nov., Lactobacillus mellis sp. nov., Lactobacillus melliventris sp. nov., Lactobacillus kimbladii sp. nov., Lactobacillus helsingborgensis sp. nov. and Lactobacillus kullabergensis sp. nov., isolated from the honey stomach of the honeybee Apis mellifera. Int J Syst Evol Microbiol. 2014;64:3109-3119.
– reference: Tubelius P, Stan V, Zachrisson A. Increasing work-place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo-controlled study. Environ Health. 2005;4:25.
– reference: Cleland EJ, Drilling A, Bassiouni A, et al. Probiotic manipulation of the chronic rhinosinusitis microbiome. Int Forum Allergy Rhinol. 2014;4:309-314.
– reference: Butler E, Oien RF, Lindholm C, et al. A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens. Int Wound J. (in press). Epub 2014 Sep 8. doi: 10.1111/iwj.12360.
– reference: Zelaya H, Tsukida K, Chiba E, et al. Immunobiotic lactobacilli reduce viral-associated pulmonary damage through the modulation of inflammation-coagulation interactions. Int Immunopharmacol. 2014;19:161-173.
– reference: Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;(23):3 p preceding table of contents, 1-298.
– reference: Roos K, Hakansson EG, Holm S. Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial. BMJ. 2001;322:210-212.
– reference: Medina M, Villena J, Salva S, et al. Nasal administration of Lactococcus lactis improves local and systemic immune responses against Streptococcus pneumoniae. Microbiol Immunol. 2008;52:399-409.
– reference: Gueimonde M, Salminen S. New methods for selecting and evaluating probiotics. Dig Liver Dis. 2006;38:S242-S247.
– reference: Greiff L, Cervin A, Ahlstrom-Emanuelsson C, et al. Repeated intranasal TLR7 stimulation reduces allergen responsiveness in allergic rhinitis. Respir Res. 2012;13:53.
– reference: Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994;8:1314-1325.
– reference: Mukerji SS, Pynnonen MA, Kim HM, et al. Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial. Otolaryngol Head Neck Surg. 2009;140:202-208.
– article-title: A pilot study investigating lactic acid bacterial symbionts from the honeybee in inhibiting human chronic wound pathogens
  publication-title: Int Wound J
– volume: 122
  start-page: 467
  year: 2012
  end-page: 472
  article-title: Microbiome complexity and in chronic rhinosinusitis
  publication-title: Laryngoscope
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  article-title: Intranasal administration of GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses
  publication-title: Lett Appl Microbiol
– volume: 1
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  year: 2010
  end-page: 185
  article-title: Safety assessment of probiotics for human use
  publication-title: Gut Microbes
– volume: 21
  start-page: 485
  year: 2013
  end-page: 492
  article-title: Probiotic strategies for treatment of respiratory diseases
  publication-title: Trends Microbiol
– volume: 7
  start-page: e33188
  year: 2012
  article-title: Symbionts as major modulators of insect health: lactic acid bacteria and honeybees
  publication-title: PLoS One
– volume: 4
  start-page: 151ra24
  year: 2012
  article-title: Sinus microbiome diversity depletion and enrichment mediates rhinosinusitis
  publication-title: Sci Transl Med
– volume: 19
  start-page: 161
  year: 2014
  end-page: 173
  article-title: Immunobiotic lactobacilli reduce viral‐associated pulmonary damage through the modulation of inflammation‐coagulation interactions
  publication-title: Int Immunopharmacol
– volume: 8
  start-page: 1314
  year: 1994
  end-page: 1325
  article-title: The interleukin‐1 family: 10 years of discovery
  publication-title: FASEB J
– volume: 4
  start-page: 25
  year: 2005
  article-title: Increasing work‐place healthiness with the probiotic : a randomised, double‐blind placebo‐controlled study
  publication-title: Environ Health
– volume: 29
  start-page: 312
  year: 2010
  end-page: 316
  article-title: Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double‐blind, placebo‐controlled trial
  publication-title: Clin Nutr
– volume: 52
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  year: 2008
  end-page: 409
  article-title: Nasal administration of improves local and systemic immune responses against
  publication-title: Microbiol Immunol
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  year: 2012
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  publication-title: Rhinol Suppl
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  article-title: IL‐15 is chemotactic for natural killer cells and stimulates their adhesion to vascular endothelium
  publication-title: J Leukoc Biol
– volume: 322
  start-page: 210
  year: 2001
  end-page: 212
  article-title: Effect of recolonisation with "interfering" alpha streptococci on recurrences of acute and secretory otitis media in children: randomised placebo controlled trial
  publication-title: BMJ
– volume: 64
  start-page: 3109
  year: 2014
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  article-title: sp. nov., sp. nov., sp. nov., sp. nov., sp. nov., sp. nov. and sp. nov., isolated from the honey stomach of the honeybee
  publication-title: Int J Syst Evol Microbiol
– article-title: Lactic acid bacterial symbionts in honeybees—an unknown key to honey's antimicrobial and therapeutic activities
  publication-title: Int Wound J
– volume: 34
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  year: 2009
  end-page: 454
  article-title: Psychometric validity of the 22‐item Sinonasal Outcome Test
  publication-title: Clin Otolaryngol
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  article-title: Structure, function and diversity of the healthy human microbiome
  publication-title: Nature
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  article-title: Consumption of a fermented dairy product containing the probiotic DN‐114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial
  publication-title: Br J Nutr
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  year: 2009
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  article-title: Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media
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  article-title: Probiotics as adjunctive treatment for chronic rhinosinusitis: a randomized controlled trial
  publication-title: Otolaryngol Head Neck Surg
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  year: 2013
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  article-title: Human eosinophils produce the T cell‐attracting chemokines MIG and IP‐10 upon stimulation with IFN‐gamma
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Snippet Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be...
Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be beneficial in...
Background Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be...
BACKGROUND: Lactic acid bacteria (LAB) can restore commensal microbiomes and prevent infections. Arguably, nasal administrations of LAB may therefore be...
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proquest
pubmed
crossref
wiley
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SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 956
SubjectTerms Administration, Intranasal
Adult
Animals
Bacteria
Bacteria - isolation & purification
bacterial interference
bacteriology
Bees - microbiology
bifidobacteria
Biomarkers
Clinical Medicine
Cross-Over Studies
Cytokines
Cytokines - immunology
Double-Blind Method
Ear diseases
Female
Humans
Klinisk medicin
lactobacillus
Lungmedicin och allergi
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Microbiota
Nasal Lavage Fluid - immunology
Nasal Lavage Fluid - microbiology
paranasal sinuses
probiotics
Respiratory Medicine and Allergy
SNOT-22
therapeutics
Young Adult
Title Effects of a honeybee lactic acid bacterial microbiome on human nasal symptoms, commensals, and biomarkers
URI https://api.istex.fr/ark:/67375/WNG-NL78KXST-2/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Falr.21762
https://www.ncbi.nlm.nih.gov/pubmed/27080343
https://www.proquest.com/docview/1816610699
https://www.proquest.com/docview/1817064443
https://lup.lub.lu.se/record/ae30f5f4-dc06-450f-884a-bd38016247b9
oai:portal.research.lu.se:publications/ae30f5f4-dc06-450f-884a-bd38016247b9
Volume 6
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