Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae
In response to this potential clinical problem, we retrospectively genotyped 17 colistin-resistant (European Committee on Antimicrobial Susceptibility Testing clinical breakpoint for resistance >2 μg/mL) Enterobacteriaceae isolates, including nine Salmonella spp, two Pantoea agglomerans, two E c...
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| Published in | The Lancet infectious diseases Vol. 16; no. 3; pp. 287 - 288 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Ltd
01.03.2016
Elsevier Limited |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In response to this potential clinical problem, we retrospectively genotyped 17 colistin-resistant (European Committee on Antimicrobial Susceptibility Testing clinical breakpoint for resistance >2 μg/mL) Enterobacteriaceae isolates, including nine Salmonella spp, two Pantoea agglomerans, two E coli, and four K pneumoniae, collected between January, 2013, and November, 2015, from a tertiary hospital in Suzhou, China, for the presence of the mcr-1 gene by use of a previously described PCR assay.1 The mcr-1 gene was detected in four isolates (two E coli and two K pneumoniae; table), and sequencing of the PCR amplicons confirmed they all carry mcr-1. CTX-M-1 Minimum inhibitory concentration (μg/mL)*  Ampicillin >16 >16 >16 >16  Cefazolin >16 >16 >16 >16  Ceftazidime 16 8 >16 >16  Cefotaxime >32 >32 >32 >32  Cefepime >16 >16 >16 >16  Aztreonam >16 16 <=2 >16  Piperacillin >64 >64 >64 >64  Piperacillin-tazobactam <=4/4 <=4/4 >64/4 >64/4  Ampicillin-sulbactam 16/8 <=4/2 >16/8 >16/8  Amoxicillin-clavulanate 8/4 <=4/2 >16/8 >16/8  Imipenem <=1 <=1 >8 >8  Meropenem <=1 <=1 >8 >8  Amikacin <=8 <=8 <=8 <=8  Gentamicin <=2 >8 >8 >8  Ciprofloxacin >2 1 2 2  Levofloxacin >8 <=1 4 4  Moxifloxacin >4 2 >4 4  Co-trimoxazole >2/38 >2/38 >2/38 >2/38  Tetracycline >8 >8 >8 >8  Chloramphenicol >16 >16 >16 >16  Colistin >2 >2 >2 >2 Table Characteristics of mcr-1-harbouring isolates ESBL=extended-spectrum β-lactamase. |
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| AbstractList | In response to this potential clinical problem, we retrospectively genotyped 17 colistin-resistant (European Committee on Antimicrobial Susceptibility Testing clinical breakpoint for resistance >2 μg/mL) Enterobacteriaceae isolates, including nine Salmonella spp, two Pantoea agglomerans, two E coli, and four K pneumoniae, collected between January, 2013, and November, 2015, from a tertiary hospital in Suzhou, China, for the presence of the mcr-1 gene by use of a previously described PCR assay.1 The mcr-1 gene was detected in four isolates (two E coli and two K pneumoniae; table), and sequencing of the PCR amplicons confirmed they all carry mcr-1. CTX-M-1 Minimum inhibitory concentration (μg/mL)*  Ampicillin >16 >16 >16 >16  Cefazolin >16 >16 >16 >16  Ceftazidime 16 8 >16 >16  Cefotaxime >32 >32 >32 >32  Cefepime >16 >16 >16 >16  Aztreonam >16 16 <=2 >16  Piperacillin >64 >64 >64 >64  Piperacillin-tazobactam <=4/4 <=4/4 >64/4 >64/4  Ampicillin-sulbactam 16/8 <=4/2 >16/8 >16/8  Amoxicillin-clavulanate 8/4 <=4/2 >16/8 >16/8  Imipenem <=1 <=1 >8 >8  Meropenem <=1 <=1 >8 >8  Amikacin <=8 <=8 <=8 <=8  Gentamicin <=2 >8 >8 >8  Ciprofloxacin >2 1 2 2  Levofloxacin >8 <=1 4 4  Moxifloxacin >4 2 >4 4  Co-trimoxazole >2/38 >2/38 >2/38 >2/38  Tetracycline >8 >8 >8 >8  Chloramphenicol >16 >16 >16 >16  Colistin >2 >2 >2 >2 Table Characteristics of mcr-1-harbouring isolates ESBL=extended-spectrum β-lactamase. |
| Author | Kreiswirth, Barry N Tang, Yi-Wei Chen, Liang Du, Hong |
| Author_xml | – sequence: 1 givenname: Hong surname: Du fullname: Du, Hong organization: Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China – sequence: 2 givenname: Liang surname: Chen fullname: Chen, Liang email: chen11@njms.rutgers.edu organization: Public Health Research Institute Tuberculosis Center, New Jersey medical school, Rutgers University, Newark, NJ 07103, USA – sequence: 3 givenname: Yi-Wei surname: Tang fullname: Tang, Yi-Wei organization: Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA – sequence: 4 givenname: Barry N surname: Kreiswirth fullname: Kreiswirth, Barry N organization: Public Health Research Institute Tuberculosis Center, New Jersey medical school, Rutgers University, Newark, NJ 07103, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26842776$$D View this record in MEDLINE/PubMed |
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| References_xml | – volume: 16 start-page: 144 year: 2016 end-page: 145 ident: bib6 article-title: Dissemination of the publication-title: Lancet Infect Dis – volume: 20 start-page: 30085 year: 2015 ident: bib2 article-title: Detection of publication-title: Euro Surveill – volume: 16 start-page: 144 year: 2016 end-page: 145 ident: bib5 article-title: Dissemination of the publication-title: Lancet Infect Dis – volume: 16 start-page: 147 year: 2016 end-page: 149 ident: bib3 article-title: Dissemination of the publication-title: Lancet Infect Dis – volume: 16 start-page: 161 year: 2016 end-page: 168 ident: bib1 article-title: Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study publication-title: Lancet Infect Dis – volume: 16 start-page: 147 year: 2016 ident: bib4 article-title: Dissemination of the publication-title: Lancet Infect Dis – volume: 16 start-page: 144 year: 2016 ident: 10.1016/S1473-3099(16)00056-6_bib6 article-title: Dissemination of the mcr-1 colistin resistance gene publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)00532-0 – volume: 16 start-page: 147 year: 2016 ident: 10.1016/S1473-3099(16)00056-6_bib4 article-title: Dissemination of the mcr-1 colistin resistance gene publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)00540-X – volume: 16 start-page: 144 year: 2016 ident: 10.1016/S1473-3099(16)00056-6_bib5 article-title: Dissemination of the mcr-1 colistin resistance gene publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)00538-1 – volume: 20 start-page: 30085 year: 2015 ident: 10.1016/S1473-3099(16)00056-6_bib2 article-title: Detection of mcr-1 encoding plasmid-mediated colistin-resistant Escherichia coli isolates from human bloodstream infection and imported chicken meat, Denmark 2015 publication-title: Euro Surveill doi: 10.2807/1560-7917.ES.2015.20.49.30085 – volume: 16 start-page: 161 year: 2016 ident: 10.1016/S1473-3099(16)00056-6_bib1 article-title: Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)00424-7 – volume: 16 start-page: 147 year: 2016 ident: 10.1016/S1473-3099(16)00056-6_bib3 article-title: Dissemination of the mcr-1 colistin resistance gene publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(15)00541-1 – reference: 26603172 - Lancet Infect Dis. 2016 Feb;16(2):161-8 |
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| SubjectTerms | Animals Colistin - therapeutic use CRE bacteria E coli Enterobacteriaceae - drug effects Enterobacteriaceae Infections - drug therapy Enterobacteriaceae Infections - immunology Genes Humans Infectious Disease Infectious diseases Plasmids Plasmids - immunology Polymyxins - therapeutic use Swine Diseases - drug therapy |
| Title | Emergence of the mcr-1 colistin resistance gene in carbapenem-resistant Enterobacteriaceae |
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