ATP is a Coupling Modulator of Parallel Na,K-ATPase-K-Channel Activity in the Renal Proximal Tubule

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 89; no. 14; pp. 6418 - 6422
• Main Authors: Tsuchiya, K., Wang, W., Giebisch, G., Welling, P. A.
• Format: Journal Article
• Language: English
• Published: Washington, DC National Academy of Sciences of the United States of America 15.07.1992; National Acad Sciences; National Academy of Sciences
• Subjects: Adenosine triphosphatases; Adenosine Triphosphate - physiology; Animals; ATP; Biochemistry; Biological and medical sciences; Cell membranes; Cell physiology; Fundamental and applied biological sciences. Psychology; Glyburide - pharmacology; In Vitro Techniques; Ion Channel Gating; Kidney Tubules, Proximal - physiology; Kidneys; Membrane and intracellular transports; Membrane potential; Membrane Potentials - drug effects; Modulated signal processing; Molecular and cellular biology; Na super(+)/K super(T)-transporting ATPase; P branes; Physiological transport; Physiology; Potassium - metabolism; Potassium Channels - physiology; Proximal tubules; Pumps; Rabbits; Recycling; role; Signal Transduction; Sodium - metabolism; Sodium-Potassium-Exchanging ATPase - physiology; Enzyme; Electrophysiology; Rabbit; Ion transport; Ionic channel; Lagomorpha; Kidney; Vertebrata; Regulation(control); Mammalia; Na,K-ATPase; Coupling; Intracellular; ATP; Potassium; Proximal tube

A fundamental and essential property of nearly all salt-transporting epithelia is the tight parallel coupling between the magnitude of the K-conductive pathway at the basolateral membrane and the activity of the Na,K-dependent ATPase (Na,K-ATPase). In the present study, we demonstrate that the coupl...