MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

• Published in: Nature communications Vol. 8; no. 1; p. 15497
• Main Authors: Lopez, Juan Pablo, Fiori, Laura M., Cruceanu, Cristiana, Lin, Rixing, Labonte, Benoit, Cates, Hannah M., Heller, Elizabeth A., Vialou, Vincent, Ku, Stacy M., Gerald, Christophe, Han, Ming-Hu, Foster, Jane, Frey, Benicio N., Soares, Claudio N., Müller, Daniel J., Farzan, Faranak, Leri, Francesco, MacQueen, Glenda M., Feilotter, Harriet, Tyryshkin, Kathrin, Evans, Kenneth R., Giacobbe, Peter, Blier, Pierre, Lam, Raymond W., Milev, Roumen, Parikh, Sagar V., Rotzinger, Susan, Strother, Steven C., Lewis, Cathryn M., Aitchison, Katherine J., Wittenberg, Gayle M., Mechawar, Naguib, Nestler, Eric J., Uher, Rudolf, Kennedy, Sidney H., Turecki, Gustavo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.05.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 13/100; 38/109; 64/60; 692/308/53/2422; 692/53/2422; Adult; Aged; Animals; Antidepressive Agents - therapeutic use; Biomarkers; Brain - pathology; Brain research; Cognitive science; Computational Biology; Depressive Disorder, Major - drug therapy; Depressive Disorder, Major - genetics; Duloxetine Hydrochloride - therapeutic use; Female; Gene Expression Regulation; Genes; HEK293 Cells; Humanities and Social Sciences; Humans; Kinases; Male; MAP Kinase Signaling System; Mental depression; Mental disorders; Mental health; Mice; Mice, Inbred C57BL; MicroRNAs; MicroRNAs - genetics; Middle Aged; multidisciplinary; Neuroscience; Neurosciences; Psychiatry; R&D; Research & development; Science; Science (multidisciplinary); Wnt Signaling Pathway; Young Adult; Ontario Canada; New York; Canada; Toronto Ontario Canada; United States > US

Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using sm...