Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2

• Published in: iScience Vol. 25; no. 5; p. 104239
• Main Authors: Francesconi, Oscar, Donnici, Lorena, Fragai, Marco, Pesce, Elisa, Bombaci, Mauro, Fasciani, Alessandra, Manganaro, Lara, Conti, Matteo, Grifantini, Renata, De Francesco, Raffaele, Nativi, Cristina, Roelens, Stefano
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.05.2022; Elsevier
• Subjects: Biological sciences; Carbohydrate; Microbiology; Microbiology; Biological sciences; Carbohydrate

Developing strategies against the SARS-CoV-2 is currently a main research subject. SARS-CoV-2 infects host cells by binding to human ACE2 receptors. Both, virus and ACE2, are highly glycosylated, and exploiting glycans of the SARS-CoV-2 envelope as binding sites for ACE2 represents a virus strategy...