Broad antagonism of coronaviruses nsp5 to evade the host antiviral responses by cleaving POLDIP3

• Published in: PLoS pathogens Vol. 19; no. 10; p. e1011702
• Main Authors: Wu, Yang, Li, Mingwei, Tian, Jin, Yan, Haoxin, Pan, Yudi, Shi, Hongyan, Shi, Da, Chen, Jianfei, Guo, Longjun, Feng, Li
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 06.10.2023; Public Library of Science (PLoS)
• Subjects: Analysis; Animal diseases; Animal health; Biology and life sciences; Cleavage; Control; Coronaviridae; Coronaviruses; COVID-19; CRISPR; Diarrhea; Disease transmission; DNA polymerase; DNA polymerases; DNA-directed DNA polymerase; Genes; Glutamine; Hogs; Identification and classification; Infection; Infections; Innate immunity; Interferon; Kinases; Liver diseases; Medicine and Health Sciences; Pathogens; Proteases; Proteins; Public safety; Research and Analysis Methods; RNA; RNA viruses; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Suckling behavior; Swine; Viral diseases; Viral infections; Virus diseases; Viruses; Western blotting; China

Coronaviruses (CoVs) are a family of the largest RNA viruses that typically cause respiratory, enteric, and hepatic diseases in animals and humans, imposing great threats to the public safety and animal health. Porcine deltacoronavirus (PDCoV), a newly emerging enteropathogenic coronavirus, causes s...