Upregulated ClC3 Channels/Transporters Elicit Swelling-Activated Cl− Currents and Induce Excessive Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension

• Published in: Biological & pharmaceutical bulletin Vol. 45; no. 11; pp. 1684 - 1691
• Main Authors: Amano, Taiki, Yamamura, Aya, Fujiwara, Moe, Hirai, Seiji, Kondo, Rubii, Suzuki, Yoshiaki, Yamamura, Hisao
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.11.2022; Japan Science and Technology Agency
• Subjects: Calcium channels; Calcium signalling; Cell proliferation; cell swelling; chloride channel; ClC3; Hypertension; Ion channels; mRNA; Pathogenesis; proliferation; Pulmonary arteries; Pulmonary artery; Pulmonary hypertension; siRNA; Smooth muscle

Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling of the pulmonary artery, which is mainly attributed to the excessive proliferation of pulmonary arterial smooth muscle cells (PASMCs) comprising the medial layer of pulmonary arteries. The activity of ion channels associat...