Role of protease-activated receptor 1 in tumor metastasis promoted by tissue factor

• Published in: Thrombosis and haemostasis Vol. 86; no. 5; p. 1210
• Main Authors: Bromberg, M E, Bailly, M A, Konigsberg, W H
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2001
• Subjects: Animals; Disease Models, Animal; Drug Synergism; Female; Humans; Lung Neoplasms - secondary; Melanoma - pathology; Mice; Mice, SCID; Neoplasm Metastasis; Receptor, PAR-1; Receptors, Thrombin - physiology; Thromboplastin - genetics; Thromboplastin - metabolism; Thromboplastin - pharmacology; Transfection; Tumor Cells, Cultured - transplantation

Tissue factor (TF) is a transmembrane glycoprotein that complexes with factor VIIa to initiate blood coagulation. We previously reported that expression of high levels of TF in a human melanoma cell line promotes metastasis. Both the cytoplasmic domain of TF and its extracellular domain complexed wi...