Fibrin-based biomaterials to deliver human growth factors

• Published in: Thrombosis and haemostasis Vol. 89; no. 3; p. 573
• Main Authors: Wong, Catalina, Inman, Elisabeth, Spaethe, Reiner, Helgerson, Sam
• Format: Journal Article
• Language: English
• Published: Germany 01.03.2003
• Subjects: Allantois - blood supply; Allantois - drug effects; Animals; Biocompatible Materials; Cell Adhesion - drug effects; Cell Division - drug effects; Cells, Cultured; Chick Embryo; Chorion - blood supply; Chorion - drug effects; Drug Delivery Systems; Endothelial Growth Factors - administration & dosage; Endothelium, Vascular - cytology; Endothelium, Vascular - drug effects; Fibrin; Fibrin Tissue Adhesive; Fibroblast Growth Factor 2 - administration & dosage; Growth Substances - administration & dosage; Humans; Intercellular Signaling Peptides and Proteins - administration & dosage; Lymphokines - administration & dosage; Materials Testing; Neovascularization, Physiologic - drug effects; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wound Healing - drug effects
• ISSN: 0340-6245
• DOI: 10.1055/s-0037-1613389

Fibrin-based biomaterial preparations can be used as provisional growth matrices for cells important in tissue repair during wound healing in vivo. Their efficacy can be enhanced by including bioactive agents that promote specific cellular responses. This study examined the controlled delivery of th...