Treatment of Intervertebral Disk Disease by the Administration of mRNA Encoding a Cartilage-Anabolic Transcription Factor

• Published in: Molecular therapy. Nucleic acids Vol. 16; pp. 162 - 171
• Main Authors: Lin, Chin-Yu, Crowley, Samuel Thomas, Uchida, Satoshi, Komaki, Yuji, Kataoka, Kazunori, Itaka, Keiji
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.06.2019; Elsevier Limited; American Society of Gene & Cell Therapy; Elsevier
• Subjects: Cartilage; Collagen; Collagen (type II); Degeneration; Degenerative diseases; Experiments; Extracellular matrix; Fibrosis; Glycosaminoglycans; Homeostasis; Hydration; Intervertebral discs; intervertebral disk disease; Laboratories; Low back pain; Medical research; mRNA; mRNA medicine; Polyethylene glycol; polyplex nanomicelle; Protein expression; Proteins; Proteoglycans; runt-related transcription factor-1; RUNX1; transcription factor; Transcription factors; mRNA medicine; runt-related transcription factor-1; transcription factor; polyplex nanomicelle; mRNA; RUNX1; intervertebral disk disease

Intervertebral disk (IVD) degeneration is often associated with severity of lower back pain. IVD core is an avascular, highly hydrated tissue composed of type II collagen, glycosaminoglycans, and proteoglycans. The disk degeneration is not only a destruction of IVD structure but also is related to a...