CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease

• Published in: Thrombosis and haemostasis Vol. 103; no. 4; p. 788
• Main Authors: Missiou, Anna, Wolf, Dennis, Platzer, Isabel, Ernst, Sandra, Walter, Carina, Rudolf, Philipp, Zirlik, Katja, Köstlin, Natascha, Willecke, Florian K, Münkel, Christian, Schönbeck, Uwe, Libby, Peter, Bode, Christoph, Varo, Nerea, Zirlik, Andreas
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2010
• Subjects: 3T3-L1 Cells; Adipocytes - immunology; Adipocytes - metabolism; Adipogenesis; Animals; Cardiovascular Diseases - genetics; Cardiovascular Diseases - immunology; Cardiovascular Diseases - metabolism; Case-Control Studies; CCAAT-Enhancer-Binding Proteins - metabolism; CD40 Antigens - metabolism; CD40 Ligand - blood; CD40 Ligand - genetics; CD40 Ligand - metabolism; Chemokine CCL2 - metabolism; Culture Media, Conditioned - metabolism; Endothelial Cells - immunology; Endothelial Cells - metabolism; Humans; Inflammation - genetics; Inflammation - immunology; Inflammation - metabolism; Inflammation Mediators - metabolism; Interleukin-6 - blood; Interleukin-8 - metabolism; Metabolic Syndrome - genetics; Metabolic Syndrome - immunology; Metabolic Syndrome - metabolism; Mice; Mitogen-Activated Protein Kinases - metabolism; NF-kappa B - metabolism; Obesity - genetics; Obesity - immunology; Obesity - metabolism; Plasminogen Activator Inhibitor 1 - metabolism; PPAR gamma - metabolism; Recombinant Proteins - metabolism; RNA, Messenger - metabolism; Signal Transduction; Time Factors

CD40L figures prominently in atherogenesis. Recent data demonstrate elevated levels of sCD40L in the serum of patients with the metabolic syndrome (MS). This study investigated the role of CD40L in pro-inflammatory gene expression and cellular differentiation in adipose tissue to obtain insight into...