Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions
Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studi...
Saved in:
Published in | Frontiers in immunology Vol. 10; p. 1361 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
2019
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation.
Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP.
IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in FcεRI expression.
We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses. |
---|---|
AbstractList | Background:
Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation.
Methods:
Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP.
Results:
IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in FcεRI expression.
Conclusion:
We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses. Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation. Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP. IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in FcεRI expression. We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses. Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation. Methods: Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP. Results: IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in Fc epsilon RI expression. Conclusion: We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses. Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic inflammation-related conditions such as asthma. Mast cells are one of the major targets of IL-33, to which they respond by secreting cytokines. Most studies performed thus far have investigated the acute effects of IL-33 on mast cells. In the current study, we investigated how acute vs. prolonged exposure of mast cells to IL-33 and TSLP affects mediator synthesis and IgE-mediated activation.Methods: Human lung mast cells (HLMCs), cord blood-derived mast cells (CBMCs), and the ROSA mast cell line were used for this study. Receptor expression and the levels of mediators were measured after treatment with IL-33 and/or TSLP.Results: IL-33 induced the release of cytokines. Prolonged exposure to IL-33 increased while TSLP reduced intracellular levels of tryptase. Acute IL-33 treatment strongly potentiated IgE-mediated activation. In contrast, 4 days of exposure to IL-33 decreased IgE-mediated activation, an effect that was accompanied by a reduction in FcεRI expression.Conclusion: We show that IL-33 plays dual roles in mast cells, in which its acute effects include cytokine release and the potentiation of IgE-mediated degranulation, whereas prolonged exposure to IL-33 reduces IgE-mediated activation. We conclude that mast cells act quickly in response to the alarmin IL-33 to initiate an acute inflammatory response, whereas extended exposure to IL-33 during prolonged inflammation reduces IgE-mediated responses. This negative feedback effect suggests the presence of a novel regulatory pathway that modulates IgE-mediated human mast cell responses. |
Author | Arock, Michel Rönnberg, Elin Ghaib, Avan Enoksson, Mattias Nilsson, Gunnar Säfholm, Jesper Ekoff, Maria Ceriol, Carlos |
AuthorAffiliation | 6 Department of Medical Sciences, Uppsala University , Uppsala , Sweden 3 Molecular and Cellular Oncology, LBPA CNRS UMR 8113, Ecole Normale Supérieure de Cachan , Cachan , France 4 Laboratoire Central d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière , Paris , France 1 Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital , Solna , Sweden 2 Department of Microbiology, College of Medicine, University of Sulaimani , Sulaimani , Iraq 5 The Unit for Asthma and Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet , Solna , Sweden |
AuthorAffiliation_xml | – name: 3 Molecular and Cellular Oncology, LBPA CNRS UMR 8113, Ecole Normale Supérieure de Cachan , Cachan , France – name: 2 Department of Microbiology, College of Medicine, University of Sulaimani , Sulaimani , Iraq – name: 1 Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital , Solna , Sweden – name: 5 The Unit for Asthma and Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet , Solna , Sweden – name: 6 Department of Medical Sciences, Uppsala University , Uppsala , Sweden – name: 4 Laboratoire Central d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière , Paris , France |
Author_xml | – sequence: 1 givenname: Elin surname: Rönnberg fullname: Rönnberg, Elin organization: Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden – sequence: 2 givenname: Avan surname: Ghaib fullname: Ghaib, Avan organization: Department of Microbiology, College of Medicine, University of Sulaimani, Sulaimani, Iraq – sequence: 3 givenname: Carlos surname: Ceriol fullname: Ceriol, Carlos organization: Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden – sequence: 4 givenname: Mattias surname: Enoksson fullname: Enoksson, Mattias organization: Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden – sequence: 5 givenname: Michel surname: Arock fullname: Arock, Michel organization: Laboratoire Central d'Hématologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France – sequence: 6 givenname: Jesper surname: Säfholm fullname: Säfholm, Jesper organization: The Unit for Asthma and Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Solna, Sweden – sequence: 7 givenname: Maria surname: Ekoff fullname: Ekoff, Maria organization: Immunology and Allergy Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Solna, Sweden – sequence: 8 givenname: Gunnar surname: Nilsson fullname: Nilsson, Gunnar organization: Department of Medical Sciences, Uppsala University, Uppsala, Sweden |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31275312$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390195$$DView record from Swedish Publication Index http://kipublications.ki.se/Default.aspx?queryparsed=id:141170834$$DView record from Swedish Publication Index |
BookMark | eNp1UktvEzEQXqEi-qB3TshHDiT4uWtfkKI0hUit4ABcLa89G9xu7GDvFvj3dR5UzQFLfmjm-74Za77z6iTEAFX1huApY1J96Px6PU4pJmqKCavJi-qM1DWfMEr5ybP3aXWZ8x0uiyvGmHhVnTJCG1GOs8pd-QdIKwgDWnQd2CGj2KGZHQdAJjj0NcU-hhU4tAwDpB7Gex8QY2jxZxPzmADFgG5NHtAc-h4tV4vJLThvhsK4HoMdfAz5dfWyM32Gy8N9UX2_Xnybf57cfPm0nM9uJrYmYpiUTwin6rbG1FkuLe4a3IKihhnSYGFbIZmRGETDuZG1Mo1wruHUQYEIydlFtdzrumju9Cb5tUl_dTRe7wIxrbRJg7c9aMm6oqm4cbLhrMWylYIa2vKS4I3qipbaa-XfsBnbI7VNik4f4vd-u3UGTTgpkpJt-3j_X-6V_zHbdTKOmqkyPFHgH_fwgl2Ds2UYyfTHFY8ywf_Uq_iga6EYb2gReHcQSPHXCHnQa59tmYcJEMesKRWMSqYUKVC8h9oUc07QPZUhWG9tpXe20ltb6Z2tCuXt8_aeCP9MxB4BfjjLPg |
CitedBy_id | crossref_primary_10_1016_j_jaci_2021_01_002 crossref_primary_10_3390_cells10010102 crossref_primary_10_3390_cells8080829 crossref_primary_10_1182_bloodadvances_2022006969 crossref_primary_10_1111_all_14881 crossref_primary_10_1016_j_yexmp_2023_104867 crossref_primary_10_1080_10799893_2019_1690515 crossref_primary_10_3390_ijms231810864 crossref_primary_10_1007_s11883_020_00837_9 crossref_primary_10_3389_fimmu_2021_613461 crossref_primary_10_4049_jimmunol_2200916 crossref_primary_10_3390_ijms241512002 crossref_primary_10_3390_cells12232700 crossref_primary_10_1007_s40521_023_00337_6 crossref_primary_10_1016_j_cellimm_2021_104424 crossref_primary_10_3389_fonc_2021_731323 crossref_primary_10_3389_fimmu_2023_1151754 crossref_primary_10_1097_CMR_0000000000000932 crossref_primary_10_1177_0748233720948771 crossref_primary_10_1183_16000617_0144_2022 crossref_primary_10_1038_s41467_019_13853_4 crossref_primary_10_1111_imcb_12486 crossref_primary_10_3390_ijms22073580 crossref_primary_10_3389_fimmu_2020_01389 crossref_primary_10_3390_ijms25031730 crossref_primary_10_3389_fimmu_2020_615236 crossref_primary_10_3389_fimmu_2021_804812 crossref_primary_10_3390_cancers13020165 crossref_primary_10_1038_s41598_019_54878_5 |
Cites_doi | 10.1111/all.12004 10.1038/labinvest.3700663 10.4049/jimmunol.179.4.2051 10.1016/j.jaci.2016.09.049 10.1111/all.12590 10.3389/fimmu.2017.00475 10.4049/jimmunol.1003383 10.1182/blood-2012-05-434209 10.1111/all.12593 10.1189/jlb.0407200 10.1111/imr.12625 10.1111/all.12309 10.1126/science.1470922 10.1007/s00011-009-0088-5 10.1084/jem.20062211 10.1016/S2213-2600(13)70261-3 10.1002/eji.201040718 10.1038/cti.2017.54 10.1016/j.cyto.2007.09.013 10.1183/09059180.00005014 10.4049/jimmunol.0802387 10.1038/nri.2016.95 10.1016/j.jaci.2013.08.052 10.1056/NEJMoa1704064 10.1038/nri2072 10.1111/j.1398-9995.2012.02836.x 10.1016/j.jaci.2015.12.777 10.3389/fimmu.2018.02193 10.1016/j.jaci.2006.09.003 10.1056/NEJMoa012705 10.4049/jimmunol.1201576 10.1016/j.chest.2016.10.042 10.1101/463950 10.1164/rccm.201002-0295OC 10.5415/apallergy.2011.1.1.12 10.1159/000321933 10.1016/j.ejphar.2015.04.047 10.1016/j.jaci.2009.12.935 10.1074/jbc.M110.114991 10.1002/eji.201545501 10.1002/cyto.b.21547 10.1182/blood-2013-10-534685 |
ContentType | Journal Article |
Copyright | Copyright © 2019 Rönnberg, Ghaib, Ceriol, Enoksson, Arock, Säfholm, Ekoff and Nilsson. 2019 Rönnberg, Ghaib, Ceriol, Enoksson, Arock, Säfholm, Ekoff and Nilsson |
Copyright_xml | – notice: Copyright © 2019 Rönnberg, Ghaib, Ceriol, Enoksson, Arock, Säfholm, Ekoff and Nilsson. 2019 Rönnberg, Ghaib, Ceriol, Enoksson, Arock, Säfholm, Ekoff and Nilsson |
DBID | NPM AAYXX CITATION 7X8 5PM ACNBI ADTPV AOWAS D8T DF2 ZZAVC DOA |
DOI | 10.3389/fimmu.2019.01361 |
DatabaseName | PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles) SWEPUB Uppsala universitet full text SwePub SwePub Articles SWEPUB Freely available online SWEPUB Uppsala universitet SwePub Articles full text DOAJ Directory of Open Access Journals |
DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
DatabaseTitleList | PubMed |
Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Biology |
EISSN | 1664-3224 |
EndPage | 1361 |
ExternalDocumentID | oai_doaj_org_article_83f17094ad8743b08b852a2b483f479f oai_prod_swepub_kib_ki_se_141170834 oai_DiVA_org_uu_390195 10_3389_fimmu_2019_01361 31275312 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GrantInformation_xml | – fundername: AstraZeneca – fundername: Science for Life Laboratory – fundername: Stiftelsen Tornspiran – fundername: Hjärt-Lungfonden – fundername: Svenska Sällskapet för Medicinsk Forskning – fundername: Vetenskapsrådet – fundername: Stiftelsen för Strategisk Forskning – fundername: Karolinska Institutet – fundername: O. E. och Edla Johanssons Vetenskapliga Stiftelse – fundername: Stiftelsen Lars Hiertas Minne |
GroupedDBID | 53G 5VS 9T4 AAFWJ AAKDD ACGFO ACGFS ACXDI ADBBV ADRAZ AENEX AFPKN ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BCNDV DIK EBS EMOBN GROUPED_DOAJ GX1 HYE IAO IEA IHR IHW IPNFZ KQ8 M48 M~E NPM OK1 PGMZT RIG RNS RPM AAYXX CITATION 7X8 ITC 5PM ACNBI ADTPV AOWAS D8T DF2 ZZAVC |
ID | FETCH-LOGICAL-c615t-1365d96b602dc48c0f70be92a3a1705cb583a80e5744a869a75dd742de2a35843 |
IEDL.DBID | RPM |
ISSN | 1664-3224 |
IngestDate | Fri Oct 04 13:09:36 EDT 2024 Sun Oct 20 03:46:41 EDT 2024 Tue Oct 01 22:46:48 EDT 2024 Tue Sep 17 21:17:15 EDT 2024 Sat Aug 17 03:38:01 EDT 2024 Thu Sep 26 18:24:48 EDT 2024 Sat Sep 28 08:28:09 EDT 2024 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Keywords | FcεRI TSLP mast cells IL-33 IgE |
Language | English |
License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c615t-1365d96b602dc48c0f70be92a3a1705cb583a80e5744a869a75dd742de2a35843 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 This article was submitted to Cytokines and Soluble Mediators in Immunity, a section of the journal Frontiers in Immunology Reviewed by: Elzbieta Kolaczkowska, Jagiellonian University, Poland; Paul Proost, KU Leuven, Belgium Edited by: Jose Carlos Alves-Filho, University of São Paulo, Brazil |
OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593472/ |
PMID | 31275312 |
PQID | 2253283991 |
PQPubID | 23479 |
PageCount | 1 |
ParticipantIDs | doaj_primary_oai_doaj_org_article_83f17094ad8743b08b852a2b483f479f swepub_primary_oai_prod_swepub_kib_ki_se_141170834 swepub_primary_oai_DiVA_org_uu_390195 pubmedcentral_primary_oai_pubmedcentral_nih_gov_6593472 proquest_miscellaneous_2253283991 crossref_primary_10_3389_fimmu_2019_01361 pubmed_primary_31275312 |
PublicationCentury | 2000 |
PublicationDate | 2019 |
PublicationDateYYYYMMDD | 2019-01-01 |
PublicationDate_xml | – year: 2019 text: 2019 |
PublicationDecade | 2010 |
PublicationPlace | Switzerland |
PublicationPlace_xml | – name: Switzerland |
PublicationTitle | Frontiers in immunology |
PublicationTitleAlternate | Front Immunol |
PublicationYear | 2019 |
Publisher | Frontiers Media S.A |
Publisher_xml | – name: Frontiers Media S.A |
References | Kaieda (B18) 2010; 285 Halova (B41) 2018; 282 Liew (B6) 2016; 16 Joulia (B21) 2017; 140 Makrinioti (B2) 2014; 2 Saluja (B22) 2016; 778 Mitchell (B3) 2017; 151 Prefontaine (B24) 2010; 125 Allakhverdi (B9); 204 Buchheit (B17) 2016; 137 Allakhverdi (B10); 179 Corren (B5) 2017; 377 Cop (B39) 2017; 94 Ho (B32) 2007; 82 Amarasekera (B31) 2011; 1 Ohno (B1) 2012; 67 Lai (B16) 2014; 133 Rönnberg (B42) 2018 Jung (B40) 2013; 190 Enoksson (B12); 186 Enoksson (B13) 2013; 121 Vicente (B4) 2017; 6 Balzar (B26) 2011; 183 Fux (B38) 2014; 69 Andrade (B20) 2011; 41 Enoksson (B29); 3 Erjefalt (B8) 2014; 23 Iikura (B11) 2007; 87 Zhang (B33) 1992; 258 Bandara (B36) 2015; 45 Kushnir-Sukhov (B37) 2007; 119 Griesenauer (B7) 2017; 8 Sjoberg (B19) 2015; 70 Silver (B15) 2010; 59 Saleh (B28) 2014; 124 Prefontaine (B23) 2009; 183 James (B27) 2012; 67 Moulin (B14) 2007; 40 Ravindran (B30) 2018; 9 Brightling (B25) 2002; 346 Kaur (B35) 2015; 70 Kraft (B34) 2007; 7 |
References_xml | – volume: 67 start-page: 1203 year: 2012 ident: B1 article-title: Interleukin-33 in allergy publication-title: Allergy. doi: 10.1111/all.12004 contributor: fullname: Ohno – volume: 87 start-page: 971 year: 2007 ident: B11 article-title: IL-33 can promote survival, adhesion and cytokine production in human mast cells publication-title: Lab Invest. doi: 10.1038/labinvest.3700663 contributor: fullname: Iikura – volume: 179 start-page: 2051 ident: B10 article-title: Cutting edge: The ST2 ligand IL-33 potently activates and drives maturation of human mast cells publication-title: J Immunol. doi: 10.4049/jimmunol.179.4.2051 contributor: fullname: Allakhverdi – volume: 140 start-page: 497 year: 2017 ident: B21 article-title: IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2016.09.049 contributor: fullname: Joulia – volume: 70 start-page: 514 year: 2015 ident: B19 article-title: Interleukin-33 exacerbates allergic bronchoconstriction in the mice via activation of mast cells publication-title: Allergy. doi: 10.1111/all.12590 contributor: fullname: Sjoberg – volume: 8 start-page: 475 year: 2017 ident: B7 article-title: The ST2/IL-33 axis in immune cells during inflammatory diseases publication-title: Front Immunol. doi: 10.3389/fimmu.2017.00475 contributor: fullname: Griesenauer – volume: 186 start-page: 2523 ident: B12 article-title: Mast cells as sensors of cell injury through IL-33 recognition publication-title: J Immunol. doi: 10.4049/jimmunol.1003383 contributor: fullname: Enoksson – volume: 121 start-page: 530 year: 2013 ident: B13 article-title: Intraperitoneal influx of neutrophils in response to IL-33 is mast cell dependent publication-title: Blood. doi: 10.1182/blood-2012-05-434209 contributor: fullname: Enoksson – volume: 70 start-page: 556 year: 2015 ident: B35 article-title: IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk publication-title: Allergy. doi: 10.1111/all.12593 contributor: fullname: Kaur – volume: 82 start-page: 1481 year: 2007 ident: B32 article-title: IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals publication-title: J Leukoc Biol. doi: 10.1189/jlb.0407200 contributor: fullname: Ho – volume: 282 start-page: 73 year: 2018 ident: B41 article-title: Changing the threshold-Signals and mechanisms of mast cell priming publication-title: Immunol Rev. doi: 10.1111/imr.12625 contributor: fullname: Halova – volume: 69 start-page: 216 year: 2014 ident: B38 article-title: IL-33 is a mediator rather than a trigger of the acute allergic response in humans publication-title: Allergy. doi: 10.1111/all.12309 contributor: fullname: Fux – volume: 258 start-page: 1957 year: 1992 ident: B33 article-title: Neutrophil recruitment by tumor necrosis factor from mast cells in immune complex peritonitis publication-title: Science. doi: 10.1126/science.1470922 contributor: fullname: Zhang – volume: 59 start-page: 207 year: 2010 ident: B15 article-title: IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation publication-title: Inflamm Res. doi: 10.1007/s00011-009-0088-5 contributor: fullname: Silver – volume: 204 start-page: 253 ident: B9 article-title: Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells publication-title: J Exp Med. doi: 10.1084/jem.20062211 contributor: fullname: Allakhverdi – volume: 2 start-page: 226 year: 2014 ident: B2 article-title: Role of interleukin 33 in respiratory allergy and asthma publication-title: Lancet Respir Med. doi: 10.1016/S2213-2600(13)70261-3 contributor: fullname: Makrinioti – volume: 41 start-page: 760 year: 2011 ident: B20 article-title: Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33 publication-title: Eur J Immunol. doi: 10.1002/eji.201040718 contributor: fullname: Andrade – volume: 6 start-page: e165 year: 2017 ident: B4 article-title: Lessons from ten years of genome-wide association studies of asthma publication-title: Clin Transl Immunol. doi: 10.1038/cti.2017.54 contributor: fullname: Vicente – volume: 40 start-page: 216 year: 2007 ident: B14 article-title: Interleukin (IL)-33 induces the release of pro-inflammatory mediators by mast cells publication-title: Cytokine. doi: 10.1016/j.cyto.2007.09.013 contributor: fullname: Moulin – volume: 23 start-page: 299 year: 2014 ident: B8 article-title: Mast cells in human airways: the culprit? publication-title: Eur Respir Rev. doi: 10.1183/09059180.00005014 contributor: fullname: Erjefalt – volume: 183 start-page: 5094 year: 2009 ident: B23 article-title: Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells publication-title: J Immunol. doi: 10.4049/jimmunol.0802387 contributor: fullname: Prefontaine – volume: 16 start-page: 676 year: 2016 ident: B6 article-title: Interleukin-33 in health and disease publication-title: Nat Rev Immunol. doi: 10.1038/nri.2016.95 contributor: fullname: Liew – volume: 133 start-page: 1448 year: 2014 ident: B16 article-title: Increased density of intraepithelial mast cells in patients with exercise-induced bronchoconstriction regulated through epithelially derived thymic stromal lymphopoietin and IL-33 publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2013.08.052 contributor: fullname: Lai – volume: 377 start-page: 936 year: 2017 ident: B5 article-title: Tezepelumab in adults with uncontrolled asthma publication-title: N Engl J Med. doi: 10.1056/NEJMoa1704064 contributor: fullname: Corren – volume: 7 start-page: 365 year: 2007 ident: B34 article-title: New developments in FcepsilonRI regulation, function and inhibition publication-title: Nat Rev Immunol. doi: 10.1038/nri2072 contributor: fullname: Kraft – volume: 67 start-page: 958 year: 2012 ident: B27 article-title: Corticosteroid treatment selectively decreases mast cells in the smooth muscle and epithelium of asthmatic bronchi publication-title: Allergy. doi: 10.1111/j.1398-9995.2012.02836.x contributor: fullname: James – volume: 137 start-page: 1566 year: 2016 ident: B17 article-title: Thymic stromal lymphopoietin controls prostaglandin D2 generation in patients with aspirin-exacerbated respiratory disease publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2015.12.777 contributor: fullname: Buchheit – volume: 9 start-page: 2193 year: 2018 ident: B30 article-title: An optimized protocol for the isolation and functional analysis of human lung mast cells publication-title: Front Immunol. doi: 10.3389/fimmu.2018.02193 contributor: fullname: Ravindran – volume: 119 start-page: 498 year: 2007 ident: B37 article-title: Human mast cells are capable of serotonin synthesis and release publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2006.09.003 contributor: fullname: Kushnir-Sukhov – volume: 346 start-page: 1699 year: 2002 ident: B25 article-title: Mast-cell infiltration of airway smooth muscle in asthma publication-title: N Eng J Med. doi: 10.1056/NEJMoa012705 contributor: fullname: Brightling – volume: 190 start-page: 531 year: 2013 ident: B40 article-title: IL-33 induces a hyporesponsive phenotype in human and mouse mast cells publication-title: J Immunol. doi: 10.4049/jimmunol.1201576 contributor: fullname: Jung – volume: 151 start-page: 1338 year: 2017 ident: B3 article-title: Epithelial-derived cytokines in asthma publication-title: Chest. doi: 10.1016/j.chest.2016.10.042 contributor: fullname: Mitchell – year: 2018 ident: B42 article-title: Divergent effects of acute and prolonged interleukin 33 exposure on mast cell IgE-mediated functions publication-title: bioRxiv doi: 10.1101/463950 contributor: fullname: Rönnberg – volume: 183 start-page: 299 year: 2011 ident: B26 article-title: Mast cell phenotype, location, and activation in severe asthma: data from the severe asthma research program publication-title: Am J Respir Crit Care Med. doi: 10.1164/rccm.201002-0295OC contributor: fullname: Balzar – volume: 1 start-page: 12 year: 2011 ident: B31 article-title: Immunoglobulin E in health and disease publication-title: Asia Pac Allergy. doi: 10.5415/apallergy.2011.1.1.12 contributor: fullname: Amarasekera – volume: 3 start-page: 142 ident: B29 article-title: Human cord blood-derived mast cells are activated by the Nod1 agonist M-TriDAP to release pro-inflammatory cytokines and chemokines publication-title: J Innate Immun. doi: 10.1159/000321933 contributor: fullname: Enoksson – volume: 778 start-page: 68 year: 2016 ident: B22 article-title: IL-33 and thymic stromal lymphopoietin in mast cell functions publication-title: Eur J Pharmacol. doi: 10.1016/j.ejphar.2015.04.047 contributor: fullname: Saluja – volume: 125 start-page: 752 year: 2010 ident: B24 article-title: Increased IL-33 expression by epithelial cells in bronchial asthma publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2009.12.935 contributor: fullname: Prefontaine – volume: 285 start-page: 21478 year: 2010 ident: B18 article-title: Synovial fibroblasts promote the expression and granule accumulation of tryptase via interleukin-33 and its receptor ST-2 (IL1RL1) publication-title: J Biol Chem. doi: 10.1074/jbc.M110.114991 contributor: fullname: Kaieda – volume: 45 start-page: 3034 year: 2015 ident: B36 article-title: Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33 publication-title: Eur J Immunol. doi: 10.1002/eji.201545501 contributor: fullname: Bandara – volume: 94 start-page: 405 year: 2017 ident: B39 article-title: Influence of IL-6, IL-33, and TNF-alpha on human mast cell activation: lessons from single cell analysis by flow cytometry publication-title: Cytometry B Clin Cytom doi: 10.1002/cyto.b.21547 contributor: fullname: Cop – volume: 124 start-page: 111 year: 2014 ident: B28 article-title: A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection publication-title: Blood. doi: 10.1182/blood-2013-10-534685 contributor: fullname: Saleh |
SSID | ssj0000493335 |
Score | 2.4009116 |
Snippet | Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic... Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic... Background: Epithelial cytokines, including IL-33 and Thymic stromal lymphopoietin (TSLP), have attracted interest because of their roles in chronic allergic... |
SourceID | doaj swepub pubmedcentral proquest crossref pubmed |
SourceType | Open Website Open Access Repository Aggregation Database Index Database |
StartPage | 1361 |
SubjectTerms | Fc epsilon RI FcεRI IgE IL-33 Immunology mast cells Medicin och hälsovetenskap TSLP |
SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQJSQuiDfhJSPBgUNo4neOS7urgrSIA0W9WX6lpN0mVXcjtf-esb2tGlGJC4fkENuJNZ-T-cZ2vkHog614q6LCJWGiLRkQkFLRVpaudoRI4ZlIIknL7-LgkH074ke3Un3FPWFZHjgbbhda1hJiEOMVODtbKas4McQyKGCyadPXt-a3gqmTzHsppTyvS0IU1uy23dnZGLdyNZ-jTFk98UNJrv8ujvn3VsmJoGhyQotH6OGWPeJZ7vVjdC_0T9D9nE_y6iny-3GXRfxZCmdV4jUeWjxz4yZg03v84wIq9sfB4zQRuArjaddjSvH88nyIU4V46PHSrDd4L6xW-OvxvFymVB7QYgEOMI3RZ-hwMf-5d1Bu0yiUDuhKTDYvuG-EFRXxjilXtbKyoSGGmqil4yxX1KgqcMmYUaIxknsPEbMPUAX4CX2OdvqhDy8RbmviiKuVsjIw2dqm8nBLIj1xQlXeFejTtVH1eVbL0BBlRAB0AkBHAHQCoEBfotVv6kWd63QB0Ndb9PW_0C_Q-2vMNLwXcbHD9GEY1xq-UxSoE9DfAr3IGN48ikZVezgVSE7QnfRlWtJ3v5P2tuANZRJafszjYNJkv_s1S90fRx3nkhpeIHJHvegb9fb6aRcPvQ4QhMUsQIqyV__DMq_Rg2jrPFv0Bu1sLsbwFvjTxr5Lr8ofjQUYhQ priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELZQERIXVN7hJSPBgUNK1nZs54DQ0u6qIC3iwKLerMR2tqHbpN1spPbfM-OkRRF74pAc_IrlGWe-8eMbQt4VSVpqZLhkQpaxAAASa16q2E4sY0o6IQNJ0uK7PF6Kbyfpyd_r0cMAtjtdO4wntdysD64urz_DhP-EHifY249ldX7e4Smt7AAZyMAXussEF6jviwHs_-6xMOch4uZEShGDJot-33JnIyM7Fej8d2HQf49SjghHg5Ga75MHA7qk014dHpI7vn5E7vXxJq8fE3eEpzDwMhXtWYtb2pR0arutp3nt6I8NFKxX3tGwULj23VlVU87p7OqiwaVE2tR0kbdbeujXa_p1NYsXIdQH1JiDgQw6_IQs57Ofh8fxEGYhtgBnMBi9TF0mC5kwZ4W2SamSwmcs5zly7dgi1TzXiU-VELmWWa5S58Cjdh6KAH7hT8le3dT-OaHlhFlmJ1oXygtVFlnioEmmHLNSJ85G5MPNoJqLnk3DgBeCAjBBAAYFYIIAIvIFR_22HPJgh4RmszLDtDKgV9DHTOROAxQqEl3olOWsEJAhVFZG5O2NzAzMG9wMyWvfdK2B_xgHaAXwOCLPehnefooj6z28IqJG0h31ZZxTV6eBm1umGRcKar7v9WBU5aj6NQ3d7zqDa01ZGhG2oxzaTjOkn1X4mNaDk4ZRgjQXL_6n0ktyH8e2Xz16Rfa2m86_Bjy1Ld6EafIHsdofmw priority: 102 providerName: Scholars Portal |
Title | Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions |
URI | https://www.ncbi.nlm.nih.gov/pubmed/31275312 https://search.proquest.com/docview/2253283991 https://pubmed.ncbi.nlm.nih.gov/PMC6593472 https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-390195 http://kipublications.ki.se/Default.aspx?queryparsed=id:141170834 https://doaj.org/article/83f17094ad8743b08b852a2b483f479f |
Volume | 10 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZ2V0LigngTHisjwYFD2tSP2DmWbsuCFLQHFvVmxY-UsG1StY0E_56xk66I2BOH5BA7ycgzjr-ZjL9B6J1OeCk9wyVhaRkzACCxpKWIzcQQIlLL0kCSlH9NL6_ZlyVfniB-3AsTkvaNrkb1ejOqqx8ht3K7MeNjntj4Kp-lPKNMkPEpOhWU_uWi_-wgL6WUd78kwQHLxmW12bQ-iysbeYYyXxyGel5zOiGD1SiQ9t-FNP9NmBzQioalaPEQPegxJJ52sj5CJ65-jO51VSV_P0H2wuda-C1TuOMm3uOmxFPTHhwuaouvdtCxXjmLQzhw7dqbqsaU4vmvbeMDhripcV7sD3jm1mv8eTWP81DQA-5YwDIYLPUpul7Mv80u476YQmwAtPiS8ym3WarThFjDpElKkWiXkYIWnlHHaC5pIRPHBWOFTLNCcGvBb7YOugBKoc_QWd3U7gXC5YQYYiZSauGYKHWWWHgkEZaYVCbWROjDcVDVtuPMUOBreF2ooAvldaGCLiL00Y_6bT_Pdh0uNLuV6nWuwHpAxowVVgLg0YnUkpOCaAYNTGRlhN4edaZgdvhfHkXtmnav4GtFAUABCI7Q806Ht6862kCExEC7A1mGLWCQgYG7N8AIve_sYHDLRfV9GsRvW-UjShmPELmjn18hVX_9pvKH2jtwxXwtIEnZy_8W6xW67we4CxS9RmeHXeveAHQ66PMQcoDzp-UEzjmT52Hy_AG4Jxyo |
link.rule.ids | 230,315,733,786,790,870,891,2115,4043,24346,27954,27955,27956,53825,53827 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lc9MwENaUMgxceBfMU8zAgYMTRw9bPoY0mRaaTg9tpzeN9XAwSexMEs8Av56VHHcw9AIHX_SwJe3K-lZafYvQexXxXDiGS8LiPGQAQEJB8yTUA01IEhsWe5Kk6Wl8dME-X_GrPcTbuzDeaV-rolculr2y-Op9K1dL3W_9xPpn01HMU8oS0r-FbsN8Jfw3I_1bA3oppbw5lAQTLO3nxXJZOz-utOc4ylx4GOqYzemAdNYjT9t_E9b822WyQyzqF6PJA3TZdqPxQZn36q3q6Z9_MDz-cz8fovs7eIqHTfYjtGfLx-hOE7DyxxNkDp0bh7uNhRva4w2ucjzU9dbirDT4bA0Fy5k12O80Lmw9L0pMKR5_X1VuLxJXJZ5mmy0e2cUCH8_G4dTHCoEaE1hh_SR4ii4m4_PRUbiL0xBqwEMumn3MTRqrOCJGM6GjPImUTUlGM0fWoxUXNBOR5QljmYjTLOHGgEluLBQBAEQP0H5ZlfY5wvmAaKIHQqjEsiRXaWTglSQxRMciMjpAH1tpyVVDxyHBjHFCll7I0glZeiEH6JMT53U5R6TtE6r1TO6GWYJiQhtTlhkBWEpFQglOMqIYZLAkzQP0rlUGCRPPnaZkpa3qjYQfIQVsBvg6QM8a5bj-VKtcAUo6atNpSzcHdMCTe-9kHqAPjYJ1qhwWl0Pf_LqWbrMq5QEiN5Rzi6_cpc8L98iNBSvPhRkSlL3472a9RXePzqcn8uT49MtLdM8NdrMf9Qrtb9e1fQ0Ibave-Pn4C0i2O-I |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELZgEYjL8lw2PI0EBw5pU9uJnWPpQ7tAVz2waMXFih8poW1StY0E_HrGTrvawJ72kIszTmzPOP7GnnyD0DsVxblwDJeEJXnIAICEguY81D1NCE8MSzxJ0uQsOTlnny7iiyupvnzQvlZFp1wsO2Xxw8dWrpa6u48T604ngyROKeOkuzJ59za6A3OW8CuO-s8G-FJK4-ZgEtywtJsXy2XtYrnSjuMpcyliqGM3pz3SWpM8df91ePP_sMkWuahfkMYP0Pd9V5o4lHmn3qqO_vMPy-ON-voQHe5gKu43Io_QLVs-RnebxJW_nyAzdOEc7q8s3NAfb3CV476utxZnpcHTNQiWM2uw33Fc2HpelJhSPPq1qtyeJK5KPMk2WzywiwU-nY3Cic8ZAjXGsNL6yfAUnY9HXwcn4S5fQ6gBF7ms9kls0kQlETGaCR3lPFI2JRnNHGmPVrGgmYhszBnLRJJmPDYGXHNjQQSAED1CB2VV2mOE8x7RRPeEUNwynqs0MvBIwg3RiYiMDtCHvcbkqqHlkODOOEVLr2jpFC29ogP00an0Us4RavuCaj2Tu6GWYKDQxpRlRgCmUpFQIiYZUQxuMJ7mAXq7NwgJE9CdqmSlreqNhA8iBYwGODtAzxoDuXzV3sACxFum02pL-w7YgSf53uk9QO8bI2tVGRbf-r75dS3dplUaB4hcI-cWYbkrnxfukhsL3p5LNyQoe37jZr1B96bDsfxyevb5BbrvxrrZlnqJDrbr2r4CoLZVr_2U_AsPzz5i |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Divergent+Effects+of+Acute+and+Prolonged+Interleukin+33+Exposure+on+Mast+Cell+IgE-Mediated+Functions&rft.jtitle=Frontiers+in+immunology&rft.au=Ronnberg%2C+E&rft.au=Ghaib%2C+A&rft.au=Ceriol%2C+C&rft.au=Enoksson%2C+M&rft.date=2019&rft.issn=1664-3224&rft.eissn=1664-3224&rft.volume=10&rft.spage=1361&rft_id=info:doi/10.3389%2Ffimmu.2019.01361&rft.externalDocID=oai_prod_swepub_kib_ki_se_141170834 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1664-3224&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1664-3224&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1664-3224&client=summon |