Dynamic changes in hepatitis C virus genotypes and sequence patterns in plasma donors exposed to reinfection

• Published in: Journal of medical virology Vol. 63; no. 3; pp. 228 - 236
• Main Authors: Zhang, Shu-min, Hui, Zhuang, Li, He-min, Qi, Zi-bai, Widell, Anders
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01.03.2001; Wiley-Liss
• Subjects: Basic Medicine; Biological and medical sciences; Blood Banks; Blood Donors; Blood Specimen Collection - adverse effects; Cloning, Molecular; Cross Infection - etiology; Genotype; Hepacivirus - classification; Hepacivirus - genetics; Hepatitis C - etiology; Hepatitis C - transmission; Hepatitis C - virology; Hepatitis C Antibodies - analysis; Hepatitis C virus; Human viral diseases; Humans; infected plasma donors; Infectious diseases; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Microbiology in the Medical Area; Mikrobiologi inom det medicinska området; Molecular Sequence Data; mutation rate; nosocomial infection; Phylogeny; Polymerase Chain Reaction; quasispecies; Recurrence; RNA, Viral - blood; Viral Core Proteins - immunology; Viral diseases; Viral Envelope Proteins - immunology; Viral hepatitis; Human; Nosocomial infection; Genetic variability; Hepatic disease; Genotype; Infection; Virus; Viral disease; Digestive diseases; Mutation; Transmission from man to man; Flaviviridae; Hepatitis C virus; Hepacivirus; Blood donor; Viral hepatitis C

Sequential serum samples from four plasma donors (designated A, B, C, and D) at a Chinese blood bank with hepatitis C transmission problems were studied from 1994 to 1997. The samples were examined for antibodies to HCV, for HCV viremia by PCR and HCV genotyping. Co‐ and superinfections were studied...