Lenvatinib prevents liver fibrosis by inhibiting hepatic stellate cell activation and sinusoidal capillarization in experimental liver fibrosis - Ogawa, Hiroyuki; Kaji, Kosuke; Nishimura, Norihisa; Takagi, Hirotetsu; Ishida, Koji; Takaya, Hiroaki; Kawaratani, Hideto; Moriya, Kei; Namisaki, Tadashi; Akahane, Takemi; Yoshiji, Hitoshi (Journal of Cellular and Molecular Medicine, 2021)
Keywords: AKT protein; Angiogenesis; Animals; Apoptosis; Bile; Capillaries; Carbon Tetrachloride; Cell activation; Cell adhesion & migration; Cell growth; Cells, Cultured; Cellulose; Chemotaxis; Collagen (type I); Extracellular signal-regulated kinase; Fibroblast growth factor 2; Fibrosis; Gene expression; Growth factors; hepatic stellate cell; Hepatic Stellate Cells; Hypertension; Injection; Kinases; Laboratory animals; lenvatinib; Liver; Liver cancer; Liver Cirrhosis; liver fibrosis; Male; Neovascularization, Pathologic; Oral administration; Original; PDGF; Phenotypes; Phenylurea Compounds; Phosphatase; Phosphorylation; Platelet-derived growth factor; Protein Kinase Inhibitors; Proteins; Quinolines; Rats; Rats, Inbred F344; Smad2 protein; Stellate cells; Transforming growth factor-b1; Vascular endothelial growth factor; Vascularization; VEGF; United States--US; Japan; liver fibrosis; hepatic stellate cell; lenvatinib; PDGF; VEGF; angiogenesis