维生素D与2型糖尿病患者握力的相关性研究
目的分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响。方法对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25（OH）D3水平,应用握力计测定双手握力。分析维生素D水平对握力的影响。结果与正常对照组相比较：2型糖尿病患者维生素D水平偏低[男：（12.45±6.93）ng/m L对（16.25±6.73）ng/m L;女：（10.67±6.23）ng/m L对（13.29±6.24）ng/m L,均P〈0.05],握力低于正常对照组[男：（35.34±8.86）kg对（37.67±10.27）kg;女：（23.30±5.95）kg对（35....
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| Published in | 中国骨质疏松杂志 Vol. 23; no. 8; pp. 1049 - 1053 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
胜利油田中心医院内分泌科,山东东营,257000%胜利油田中心医院麻醉科,山东东营,257000
2017
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1006-7108 |
| DOI | 10.3969/j.issn.1006-7108.2017.08.015 |
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| Abstract | 目的分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响。方法对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25（OH）D3水平,应用握力计测定双手握力。分析维生素D水平对握力的影响。结果与正常对照组相比较：2型糖尿病患者维生素D水平偏低[男：（12.45±6.93）ng/m L对（16.25±6.73）ng/m L;女：（10.67±6.23）ng/m L对（13.29±6.24）ng/m L,均P〈0.05],握力低于正常对照组[男：（35.34±8.86）kg对（37.67±10.27）kg;女：（23.30±5.95）kg对（35.34±8.86）kg,均P〈0.05],女性股骨颈密度低于对照组[（0.89±0.13）kg对（1.05±0.16）g/cm^2,P〈0.05];（2）126名糖尿病患者平均年龄58.7±11.7岁,男女比例65：61,男女患者分别按照25（OH）D3水平分为3组：严重缺乏组（〈10 ng/m L）;缺乏组（≥10 ng/m L而〈20 ng/m L）;不足组（≥20 ng/m L而〈30 ng/m L）。男性患者中,与维生素D不足组相比较,严重缺乏组的骨密度降低,握力减少,差异具有统计学差异[（33.54±7.77）kg对（39.34±5.91）kg,P〈0.05]。女性患者中,与维生素D不足组相比较,维生素D缺乏组、严重缺乏组的骨密度减低,握力降低[（18.03±5.32）kg对（22.68±6.78）kg、（28.10±0.07）kg,P均〈0.05];（3）多元直线逐步回归分析显示2型糖尿病患者中25（OH）D3与握力呈正相关（r=0.239,P=0.031）,且独立于年龄、性别、股骨颈骨密度。结论 2型糖尿病患者维生素D水平同握力之间存在独立正相关。 |
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| AbstractList | R589.9; 目的 分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响.方法 对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25 (OH)D3水平,应用握力计测定双手握力.分析维生素D水平对握力的影响.结果 与正常对照组相比较:2型糖尿病患者维生素D水平偏低[男:(12.45±6.93) ng/mL对(16.25±6.73) ng/mL;女:(10.67±6.23) ng/mL对(13.29±6.24) ng/mL,均P＜0.05],握力低于正常对照组[男:(35.34 ±8.86) kg对(37.67±10.27) kg;女:(23.30土5.95)kg对(35.34 ±8.86)kg,均P＜0.05],女性股骨颈密度低于对照组[(0.89 ±0.13)kg对(1.05±0.16)g/cm2,P ＜0.05];②126名糖尿病患者平均年龄58.7±11.7岁,男女比例65:61,男女患者分别按照25(OH)D3水平分为3组:严重缺乏组(＜ 10 ng/mL);缺乏组(≥10 ng/mL而＜20 ng/mL);不足组(≥20 ng/mL而＜30 ng/mL).男性患者中,与维生素D不足组相比较,严重缺乏组的骨密度降低,握力减少,差异具有统计学差异[(33.54±7.77)kg对(39.34±5.91)kg,P＜0.05].女性患者中,与维生素D不足组相比较,维生素D缺乏组、严重缺乏组的骨密度减低,握力降低[(18.03±5.32)kg对(22.68±6.78)kg、(28.10±0.07)kg,P均＜0.05];③多元直线逐步回归分析显示2型糖尿病患者中25(OH)D3与握力呈正相关(r =0.239,P=0.031),且独立于年龄、性别、股骨颈骨密度.结论 2型糖尿病患者维生素D水平同握力之间存在独立正相关. 目的分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响。方法对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25（OH）D3水平,应用握力计测定双手握力。分析维生素D水平对握力的影响。结果与正常对照组相比较：2型糖尿病患者维生素D水平偏低[男：（12.45±6.93）ng/m L对（16.25±6.73）ng/m L;女：（10.67±6.23）ng/m L对（13.29±6.24）ng/m L,均P〈0.05],握力低于正常对照组[男：（35.34±8.86）kg对（37.67±10.27）kg;女：（23.30±5.95）kg对（35.34±8.86）kg,均P〈0.05],女性股骨颈密度低于对照组[（0.89±0.13）kg对（1.05±0.16）g/cm^2,P〈0.05];（2）126名糖尿病患者平均年龄58.7±11.7岁,男女比例65：61,男女患者分别按照25（OH）D3水平分为3组：严重缺乏组（〈10 ng/m L）;缺乏组（≥10 ng/m L而〈20 ng/m L）;不足组（≥20 ng/m L而〈30 ng/m L）。男性患者中,与维生素D不足组相比较,严重缺乏组的骨密度降低,握力减少,差异具有统计学差异[（33.54±7.77）kg对（39.34±5.91）kg,P〈0.05]。女性患者中,与维生素D不足组相比较,维生素D缺乏组、严重缺乏组的骨密度减低,握力降低[（18.03±5.32）kg对（22.68±6.78）kg、（28.10±0.07）kg,P均〈0.05];（3）多元直线逐步回归分析显示2型糖尿病患者中25（OH）D3与握力呈正相关（r=0.239,P=0.031）,且独立于年龄、性别、股骨颈骨密度。结论 2型糖尿病患者维生素D水平同握力之间存在独立正相关。 |
| Abstract_FL | Objective To analyze the relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients,and to investigate the effect of vitamin D on grip strength.Methods One hundred and twenty-six patients with type 2 diabetes were enrolled.All subjects were measured for body mass index (BMI),bone mineral density (BMD) of the femoral neck and serum 25-hydroxyvitamin D (25 (OH)D3) levels.Subjects were assessed for grip strength using a handgrip dynamometer.Linear regression analysis was used to determine the associations between vitamin D and grip strength.Results Compared with healthy controls,type 2 diabetes patients had lower 25-hydroxyvitamin D (25 (OH) D3) levels (male:12.45 ± 6.93 ng/mL vs 16.25 ±6.73 ng/mL;female:10.67 ± 6.23 ng/mL vs 13.29 ± 6.24 ng/mL,both P ＜ 0.05),lower grip strength (male:35.34 ± 8.86kg vs 37.67 ± 10.27 kg;female:23.30 ±5.95 ng/mL vs 35.34 ±8.86 kg,both P ＜ 0.05),and females patients also had lower femoral neck BMD (0.89 ±0.13 g/cm2 vs 1.05 ±0.16 g/cm2,P ＜ 0.05).Sixty-five male and 61 female diabetic patients were included in this study,and the average age was 58.65 ± 11.67 years.According to the level of serum 25 (OH) D3,the male and the female patients were divided into three groups:seriously deficient group (＜ 10 ng/mL),deficient group (≥ 10 ng/mL but ＜ 20ng/mL) and insufficient group (≥20 ng/mL but ＜ 30 ng/mL).In male patients,femoral neck BMD and grip strength in the seriously deficient group were lower than those of the insufficient group (33.54 ± 7.77 kg vs39.34 ± 5.91 kg,P ＜ 0.05).In female patients,the femoral neck BMD and grip strength in the seriously deficient group and deficient group were lower than those of the insufficient group (18.03 ± 5.32 vs 22.68 ± 6.78 vs 28.10 ± 0.07 kg,P ＜ 0.05].Multiple stepwise regression analysis showed that the level of 25 (OH) D3 was positively correlated with the grip strength in type 2 diabetes mellitus patients (r =0.239,P =0.031.Conclusion There was independent positive correlation between the level of vitamin D and the muscle strength in type 2 diabetes mellitus patients. |
| Author | 刘国庆 王蓓蓓 陈新焰 徐伟民 赵连礼 司文 |
| AuthorAffiliation | 胜利油田中心医院内分泌科,山东东营257000 胜利油田中心医院麻醉科,山东东营257000 |
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| Author_FL | SI Wen ZHAO Lianli LIU Guoqing XU Weimin CHEN Xinyan WANG Beibei |
| Author_FL_xml | – sequence: 1 fullname: LIU Guoqing – sequence: 2 fullname: WANG Beibei – sequence: 3 fullname: CHEN Xinyan – sequence: 4 fullname: XU Weimin – sequence: 5 fullname: ZHAO Lianli – sequence: 6 fullname: SI Wen |
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| Keywords | 维生素D Vitamin D 握力 Diabetes mellitus Type 2 2型 Grip strength 糖尿病 |
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| Notes | Vitamin D; Diabetes mellitus; Type 2; Grip strength LIU Guoqing1, WANG Beibei1, CHEN Xinyan1, XU Weimin2, ZHAO Lianli1, SI Wen1 （1. Department of Endocrinology, Shengli Oilfield Central Hospital, Dong Ying, Shandong 257000; 2. Department of Anesthesia, Shengli Oilfield Central Hospital, Dong Ying, Shandong 257000, China） Objective To analyze the relationship between vitamin D status and grip strength in type 2 diabetes mellitus patients,and to investigate the effect of vitamin D on grip strength. Methods One hundred and twenty-six patients with type 2 diabetes were enrolled. All subjects were measured for body mass index（ BMI）,bone mineral density（ BMD） of the femoral neck and serum 25-hydroxyvitamin D（25（OH）D3） levels. Subjects were assessed for grip strength using a handgrip dynamometer. Linear regression analysis was used to determine the associations between vitamin D and grip strength. Results Compared with healthy controls,type 2 diabetes patients had lower 25-hydroxyvitamin D（25（OH）D3） levels（ male： 12. |
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| Publisher | 胜利油田中心医院内分泌科,山东东营,257000%胜利油田中心医院麻醉科,山东东营,257000 |
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| Snippet | ... R589.9; 目的 分析2型糖尿病患者的握力与维生素D的相关关系,探讨维生素D对握力的影响.方法 对126名2型糖尿病患者及121名健康人群进行研究,测定体重指数、股骨颈的骨密度、25 (OH)D3水平,应用握力计测定双手握力.分析维生素D水平对握力的影响.结果... |
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| SubjectTerms | 2型 握力 糖尿病 维生素D |
| Title | 维生素D与2型糖尿病患者握力的相关性研究 |
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