Development and validation of serological markers for detecting recent Plasmodium vivax infection

• Published in: Nature Medicine Vol. 26; no. 5; pp. 741 - 749
• Main Authors: Longley, Rhea J., White, Michael T., Takashima, Eizo, Brewster, Jessica, Morita, Masayuki, Harbers, Matthias, Obadia, Thomas, Robinson, Leanne J., Matsuura, Fumie, Liu, Zoe S. J., Li-Wai-Suen, Connie S. N., Tham, Wai-Hong, Healer, Julie, Huon, Christele, Chitnis, Chetan E., Nguitragool, Wang, Monteiro, Wuelton, Proietti, Carla, Doolan, Denise L., Siqueira, Andre M., Ding, Xavier C., Gonzalez, Iveth J., Kazura, James, Lacerda, Marcus, Sattabongkot, Jetsumon, Tsuboi, Takafumi, Mueller, Ivo
• Format: Journal Article Magazine Article
• Language: English
• Published: New York Nature Publishing Group US 01.05.2020; Nature Publishing Group
• Subjects: 631/326/417/2546; 692/308/174; 692/308/575; 692/699/255/1629; 706/134; Adult; Antibodies; Antigens; Asymptomatic; Biological markers; Biomarkers; Biomarkers - blood; Biomedical and Life Sciences; Biomedicine; Brazil - epidemiology; Cancer Research; Child; Cohort Studies; Control; Diagnosis; Early Diagnosis; Health services; Human health and pathology; Humans; IgG antibody; Immunoglobulin G; Immunoglobulin G - analysis; Immunoglobulin G - blood; Infection Control - methods; Infections; Infectious Diseases; Life Sciences; Liver; Longitudinal Studies; Malaria; Malaria, Vivax - blood; Malaria, Vivax - diagnosis; Malaria, Vivax - epidemiology; Mathematical models; Medical research; Medicine; Melanesia - epidemiology; Metabolic Diseases; Methods; Molecular Medicine; Neurosciences; Parasites; Plasmodium vivax; Plasmodium vivax - physiology; Prevalence; Proteins; Sensitivity and Specificity; Serodiagnosis; Serologic Tests - methods; Serologic Tests - standards; Serology; Testing; Thailand - epidemiology; Time Factors; Toolkits; Brazil; Thailand; Melanesia; Solomon Islands

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax inf...