Development and validation of serological markers for detecting recent Plasmodium vivax infection
A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax inf...
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| Published in | Nature Medicine Vol. 26; no. 5; pp. 741 - 749 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article Magazine Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.05.2020
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | A major gap in the
Plasmodium vivax
elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent
P. vivax
infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342
P. vivax
proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight
P. vivax
proteins classified
P. vivax
infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce
P. vivax
prevalence by 59–69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.
Plasmodium vivax
can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify
P. vivax
carriers for targeted treatment intervention. |
|---|---|
| AbstractList | A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59-69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59–69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy. Plasmodium vivax can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify P. vivax carriers for targeted treatment intervention. A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study developed a panel of serological exposure markers capable of classifying individuals with recent P. vivax infections who have a high likelihood of harboring hypnozoites. We measured IgG antibody responses to 342 P. vivax proteins in longitudinal clinical cohorts conducted in Thailand and Brazil and identified candidate serological markers of exposure. Candidate markers were validated using samples from year-long observational cohorts conducted in Thailand, Brazil and the Solomon Islands and antibody responses to eight P. vivax proteins classified P. vivax infections in the previous 9 months with 80% sensitivity and specificity. Mathematical models demonstrate that a serological testing and treatment strategy could reduce P. vivax prevalence by 59–69%. These eight antibody responses can serve as a biomarker, identifying individuals who should be targeted with anti-hypnozoite therapy.Plasmodium vivax can cause a clinically silent liver-stage infection that can reactivate, triggering blood-stage disease. A new test measuring antibody responses can identify P. vivax carriers for targeted treatment intervention. |
| Audience | Academic |
| Author | Harbers, Matthias Brewster, Jessica White, Michael T. Liu, Zoe S. J. Morita, Masayuki Obadia, Thomas Li-Wai-Suen, Connie S. N. Tham, Wai-Hong Matsuura, Fumie Sattabongkot, Jetsumon Siqueira, Andre M. Lacerda, Marcus Doolan, Denise L. Mueller, Ivo Nguitragool, Wang Healer, Julie Takashima, Eizo Longley, Rhea J. Kazura, James Gonzalez, Iveth J. Chitnis, Chetan E. Huon, Christele Proietti, Carla Tsuboi, Takafumi Monteiro, Wuelton Robinson, Leanne J. Ding, Xavier C. |
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J. surname: Liu fullname: Liu, Zoe S. J. organization: Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Department of Medical Biology, University of Melbourne – sequence: 11 givenname: Connie S. N. orcidid: 0000-0003-0529-0804 surname: Li-Wai-Suen fullname: Li-Wai-Suen, Connie S. 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| ContentType | Journal Article Magazine Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature America, Inc. 2020 COPYRIGHT 2020 Nature Publishing Group The Author(s), under exclusive licence to Springer Nature America, Inc. 2020. Attribution - NonCommercial |
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| Snippet | A major gap in the
Plasmodium vivax
elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites,... A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals carrying clinically silent and undetectable liver-stage parasites,... |
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| SubjectTerms | 631/326/417/2546 692/308/174 692/308/575 692/699/255/1629 706/134 Adult Antibodies Antigens Asymptomatic Biological markers Biomarkers Biomarkers - blood Biomedical and Life Sciences Biomedicine Brazil - epidemiology Cancer Research Child Cohort Studies Control Diagnosis Early Diagnosis Health services Human health and pathology Humans IgG antibody Immunoglobulin G Immunoglobulin G - analysis Immunoglobulin G - blood Infection Control - methods Infections Infectious Diseases Life Sciences Liver Longitudinal Studies Malaria Malaria, Vivax - blood Malaria, Vivax - diagnosis Malaria, Vivax - epidemiology Mathematical models Medical research Medicine Melanesia - epidemiology Metabolic Diseases Methods Molecular Medicine Neurosciences Parasites Plasmodium vivax Plasmodium vivax - physiology Prevalence Proteins Sensitivity and Specificity Serodiagnosis Serologic Tests - methods Serologic Tests - standards Serology Testing Thailand - epidemiology Time Factors Toolkits |
| Title | Development and validation of serological markers for detecting recent Plasmodium vivax infection |
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