Hippuric acid nanocomposite enhances doxorubicin and oxaliplatin-induced cytotoxicity in MDA-MB231, MCF-7 and Caco2 cell lines

• Published in: Drug design, development and therapy Vol. 7; no. default; pp. 25 - 31
• Main Authors: Hussein Al Ali, Samer Hasan, Al-Qubaisi, Mothanna, Hussein, Mohd Zobir, Ismail, Maznah, Bullo, Saifullah
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2013; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Aqueous environments; Biotechnology; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Caco-2 Cells; Caco2 cell lines; Cancer; Cell growth; Cell Line, Tumor; Cell proliferation; Cell research; Chemotherapy; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Complications and side effects; Cytotoxicity; Dosage and administration; Doxorubicin; Doxorubicin - administration & dosage; Doxorubicin - pharmacology; Drug Synergism; Drugs; Female; Hippurates - chemistry; Hippurates - pharmacology; Hippuric acid; hippuric acid nanocomposite; Humans; Inhibitory Concentration 50; Interlayers; MCF-7; MCF-7 Cells; MDA-MB231; Nanocomposites; Organoplatinum Compounds - administration & dosage; Organoplatinum Compounds - pharmacology; Original Research; Oxaliplatin; Toxicity; Tumor cell lines; Zinc; Zinc oxide; Zinc Oxide - chemistry; Zinc oxides; zinc-layered hydroxide; Malaysia; zinc-layered hydroxide; MCF-7; hippuric acid nanocomposite; MDA-MB231; oxaliplatin; Caco2 cell lines; doxorubicin

The aim of the current study is to design a new nanocomposite for inducing cytotoxicity of doxorubicin and oxaliplatin toward MDA-MB231, MCF-7, and Caco2 cell lines. A hippuric acid (HA) zinc layered hydroxide (ZLH) nanocomposite was synthesized under an aqueous environment using HA and zinc oxide (...