Identification of anti-syntaxin 5 autoantibody as a novel serum marker of endometriosis

• Published in: Journal of Reproductive Immunology Vol. 91; no. 1; pp. 48 - 55
• Main Authors: Nabeta, Motowo, Abe, Yasuhito, Takaoka, Yuki, Kusanagi, Yasuki, Ito, Masaharu
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ireland Ltd 01.09.2011; Elsevier BV; Elsevier
• Subjects: Adolescent; Adult; Autoantibodies; Autoantibodies - blood; Autoantibodies - immunology; Biological and medical sciences; Biomarkers; Biomarkers - blood; Cell Line; ELISA; Embryology: invertebrates and vertebrates. Teratology; Endometriosis; Endometriosis - blood; Endometriosis - immunology; Enzyme-Linked Immunosorbent Assay; Female; Fundamental and applied biological sciences. Psychology; Humans; Middle Aged; Obstetrics and Gynecology; Qa-SNARE Proteins; Qa-SNARE Proteins - immunology; Sensitivity and Specificity; Serum; Syntaxin 5; Endometriosis; Serum; Syntaxin 5; ELISA; Autoimmunity; Autoantibody; Identification; Marker; Female genital diseases; Syntaxin; Vertebrata; Mammalia; Uterine diseases; ELISA assay

The sensitivity and specificity of CA125, as a sole serum marker of endometriosis, are not high enough for routine clinical assessment. To explore new markers for the diagnosis of endometriosis, serum autoantibodies in endometriotic patients were investigated employing a fibroblast cell line, two-di...