Do the protocadherins Fat and Dachsous link up to determine both planar cell polarity and the dimensions of organs?

• Published in: Nature cell biology Vol. 10; no. 12; pp. 1379 - 1382
• Main Authors: Lawrence, Peter A., Struhl, Gary, Casal, José
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2008; Nature Publishing Group
• Subjects: Abdomen; Animals; Biomedical and Life Sciences; Cadherins - metabolism; Cancer Research; Cell Biology; Cell Division; Cell Polarity; Clone Cells; commentary; Developmental Biology; Drosophila melanogaster - anatomy & histology; Drosophila melanogaster - cytology; Drosophila melanogaster - enzymology; Hypotheses; Insects; Life Sciences; Models, Biological; Morphogenesis; Organ Size; Physiological aspects; Protein Serine-Threonine Kinases - metabolism; Stem Cells; Zoology; United States; United Kingdom > UK

Most, perhaps all cells in epithelial sheets are polarized in the plane of the sheet. This type of polarity, referred to as planar cell polarity (PCP), can be expressed in the orientation of cilia and stereocilia, in oriented outgrowths such as hairs, in the plane of cell division, in directed cell...