Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin
Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal pl...
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| Published in | Journal of ginseng research Vol. 41; no. 1; pp. 69 - 77 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Elsevier B.V
01.01.2017
고려인삼학회 Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1226-8453 2093-4947 |
| DOI | 10.1016/j.jgr.2016.01.001 |
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| Abstract | Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging.
Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements.
In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture.
These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. |
|---|---|
| AbstractList | BACKGROUNDHuman skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging.METHODSAnti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements.RESULTSIn vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture.CONCLUSIONThese results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging.Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements.In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture.These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Background: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Methods: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. Results: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. Conclusion: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. Background: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P. ginseng Meyer and C. pinnatifida (GC) would have protective effects against skin aging. Methods: Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. Results: In vitro studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. Conclusion: These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. KCI Citation Count: 35 Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Meyer and , we hypothesized that the mixture of Meyer and (GC) would have protective effects against skin aging. Anti-aging activity was examined both in human dermal fibroblasts under UVB irradiation by using Western blot analysis and in healthy human skin by examining noninvasive measurements. studies showed that GC improved procollagen type I expression and diminished matrix metalloproteinase-1 secretion. Based on noninvasive measurements, skin roughness values, including total roughness (R1), maximum roughness (R2), smoothness depth and average roughness (R3), and global photodamage scores were improved by GC application. Moreover, GC ameliorated the high values of smoothness depth (R4), which means that GC reduced loss of skin moisture. These results suggest that GC can prevent aging by inhibiting wrinkle formation and increasing moisture in the human skin. |
| Author | Park, Sang-Yong Hwang, Eunson Yin, Chang Shik Kim, Hee-Taek Kim, Yong Min Yi, Tae Hoo |
| AuthorAffiliation | 1 Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, Giheung-gu, Yongin-si, Gyeonggi-do, Korea 2 Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea 3 College of Oriental Medicine, Semyung University, Jecheon, Chungbuk, Korea |
| AuthorAffiliation_xml | – name: 3 College of Oriental Medicine, Semyung University, Jecheon, Chungbuk, Korea – name: 1 Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, Giheung-gu, Yongin-si, Gyeonggi-do, Korea – name: 2 Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea |
| Author_xml | – sequence: 1 givenname: Eunson surname: Hwang fullname: Hwang, Eunson organization: Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, Giheung-gu, Yongin-si, Gyeonggi-do, Korea – sequence: 2 givenname: Sang-Yong surname: Park fullname: Park, Sang-Yong organization: Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, Giheung-gu, Yongin-si, Gyeonggi-do, Korea – sequence: 3 givenname: Chang Shik surname: Yin fullname: Yin, Chang Shik organization: Acupuncture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea – sequence: 4 givenname: Hee-Taek surname: Kim fullname: Kim, Hee-Taek organization: College of Oriental Medicine, Semyung University, Jecheon, Chungbuk, Korea – sequence: 5 givenname: Yong Min surname: Kim fullname: Kim, Yong Min organization: College of Oriental Medicine, Semyung University, Jecheon, Chungbuk, Korea – sequence: 6 givenname: Tae Hoo surname: Yi fullname: Yi, Tae Hoo email: drhoo@khu.ac.kr organization: Department of Oriental Medicinal Material and Processing, College of Life Science, Kyung Hee University Global Campus, Giheung-gu, Yongin-si, Gyeonggi-do, Korea |
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| Cites_doi | 10.1016/j.jep.2009.03.022 10.1021/jf400283w 10.5142/jgr.2013.37.425 10.2353/ajpath.2009.080599 10.1089/jmf.2013.2999 10.1016/S0140-6736(09)61460-4 10.1046/j.1523-1747.2003.12425.x 10.1371/journal.pone.0061271 10.1007/s12011-010-8752-8 10.1111/j.1365-2133.1992.tb16984.x 10.1016/j.bcp.2012.05.023 10.1159/000064533 10.1002/ptr.4943 10.1016/S1568-1637(02)00024-7 10.1074/jbc.M409647200 10.5539/ijc.v1n2p57 10.4110/in.2011.11.1.42 10.1056/NEJM199711133372003 10.1001/archderm.138.11.1462 10.1177/00970002042006003 10.1016/j.fct.2013.07.015 10.1016/j.bbrc.2004.02.046 10.1038/jidsymp.2009.8 10.1111/j.1749-6632.2009.04918.x 10.1002/ptr.4870 10.1186/1745-6215-11-2 10.1039/C3FO60418G 10.5142/jgr.2012.36.3.225 10.1101/cshperspect.a015370 10.1016/S0738-081X(01)00181-X 10.1055/s-0034-1383253 10.1089/jmf.2013.3017 10.2174/157016109788340767 10.1248/bpb.32.837 10.1089/rej.2015.1660 10.1007/s10571-009-9421-3 10.1016/j.fct.2007.03.016 |
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| Keywords | clinical study Crataegus pinnatifida antiaging Panax ginseng antiwrinkle |
| Language | English |
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| References | Quan, Qin, Xia, Shao, Voorhees, Fisher (bib6) 2009; 14 Rittié, Fisher (bib7) 2002; 1 Hwang, Park, Jo, Lee, Kim, Kim, Yin, Yi (bib24) 2015; 18 Edwards (bib26) 2010; 11 Chang, Zuo, Harrison, Chow (bib19) 2002; 42 Afaq, Mukhtar (bib27) 2002; 15 Rittié, Fisher (bib3) 2015; 5 Hwang, Lee, Park, Yi, Kim (bib17) 2014; 5 Fisher, Kang, Varani, Bata-Csorgo, Wan, Datta, Voorhees (bib5) 2002; 138 Wang, Zhang, Zhao, Zhang, Liu, Hu, Gao, Zhang (bib37) 2011; 142 Lü, Yao, Chen (bib12) 2009; 7 Fisher, Quan, Purohit, Shao, Cho, He, Varani, Kang, Voorhees (bib8) 2009; 174 Chung, Lee, Youn, Park, Kim, Park, Cho, Eun (bib25) 2001; 137 Cheng, Wang, Gao, Yuan, Feng, Cao, Zheng (bib36) 2013; 59 Fiers (bib41) 1996; 42 Kim, Kang, Cho, Sung, Chang, Yeom, Kim, Sim, Lee (bib15) 2004; 316 Sun, Hwang, Lee, Lee, Song, Park, Shin, Lee, Yi (bib32) 2015; 69 Huang, Liu, Wu, Yu, Cong, Zhang, Lou, LiL, Song (bib21) 2014; 80 Poljšak, Dahmane, Godić (bib4) 2012; 21 Shin, Lee, Park, Yang, Kim, Yi (bib22) 2013; 27 Christensen, Doblhammer, Rau, Vaupel (bib39) 2009; 374 Tu, Ma, Liu, Wang, Luo (bib34) 2009; 29 Lee, Cho, Kim, Shin, Chang, Kim, Yeom, Woe, Lee, Sim (bib16) 2003; 121 Quan, He, Voorhees, Fisher (bib30) 2005; 280 Ramos-e-Silva, Carneiro (bib40) 2001; 19 Li, Zhu, Dong, Liu, Li, Chen (bib38) 2013; 61 Hong, Lyu (bib10) 2011; 11 Hwang, Lee, Park, Oh, Kim (bib29) 2014; 17 Kang, Park, Kim, Kim, Kim, Do, Kang, Cho, Kim (bib11) 2009; 123 Gilchrest, Yaar (bib1) 1992; 127 Kwok, Yue, Mak, Wong (bib14) 2012; 84 Fisher, Wang, Datta, Varani, Kang, Voorhees (bib2) 1997; 337 Lee, Sorn, Baek, Jang, Kim (bib33) 2009; 1171 Hwang, Sun, Lee, Shin, Park, Lee, Cho, Sohn, Kwon, Kim (bib18) 2013; 37 Jackson, Williams, Feingold, Elias (bib42) 1993; 158 Hwang, Kim, Lee, Lee, Do, Kim, Kim (bib23) 2013; 27 Kim, Cho, Yoo, Lee, Han, Lee, Ahn, Son (bib35) 2013; 8 Park, Kim, Park, Kim, Ryu (bib9) 2012; 36 Cai, Jin, Luo, Lin, Gao (bib13) 2009; 32 Pena Ferreira, Costa, Bahia (bib43) 2010; 2 Kao, Wang, Lin, Chu, Tseng (bib20) 2007; 45 Chen (bib28) 2009; 1 Hwang, Park, Lee, Sun, Lee, Song, Shin, Yi (bib31) 2014; 17 Lee (10.1016/j.jgr.2016.01.001_bib33) 2009; 1171 Cai (10.1016/j.jgr.2016.01.001_bib13) 2009; 32 Kao (10.1016/j.jgr.2016.01.001_bib20) 2007; 45 Ramos-e-Silva (10.1016/j.jgr.2016.01.001_bib40) 2001; 19 Fiers (10.1016/j.jgr.2016.01.001_bib41) 1996; 42 Cheng (10.1016/j.jgr.2016.01.001_bib36) 2013; 59 Christensen (10.1016/j.jgr.2016.01.001_bib39) 2009; 374 Fisher (10.1016/j.jgr.2016.01.001_bib5) 2002; 138 Edwards (10.1016/j.jgr.2016.01.001_bib26) 2010; 11 Li (10.1016/j.jgr.2016.01.001_bib38) 2013; 61 Gilchrest (10.1016/j.jgr.2016.01.001_bib1) 1992; 127 Fisher (10.1016/j.jgr.2016.01.001_bib2) 1997; 337 Wang (10.1016/j.jgr.2016.01.001_bib37) 2011; 142 Hwang (10.1016/j.jgr.2016.01.001_bib24) 2015; 18 Hong (10.1016/j.jgr.2016.01.001_bib10) 2011; 11 Chung (10.1016/j.jgr.2016.01.001_bib25) 2001; 137 Kim (10.1016/j.jgr.2016.01.001_bib35) 2013; 8 Tu (10.1016/j.jgr.2016.01.001_bib34) 2009; 29 Pena Ferreira (10.1016/j.jgr.2016.01.001_bib43) 2010; 2 Poljšak (10.1016/j.jgr.2016.01.001_bib4) 2012; 21 Rittié (10.1016/j.jgr.2016.01.001_bib7) 2002; 1 Kim (10.1016/j.jgr.2016.01.001_bib15) 2004; 316 Jackson (10.1016/j.jgr.2016.01.001_bib42) 1993; 158 Park (10.1016/j.jgr.2016.01.001_bib9) 2012; 36 Hwang (10.1016/j.jgr.2016.01.001_bib31) 2014; 17 Shin (10.1016/j.jgr.2016.01.001_bib22) 2013; 27 Quan (10.1016/j.jgr.2016.01.001_bib6) 2009; 14 Chang (10.1016/j.jgr.2016.01.001_bib19) 2002; 42 Rittié (10.1016/j.jgr.2016.01.001_bib3) 2015; 5 Chen (10.1016/j.jgr.2016.01.001_bib28) 2009; 1 Kwok (10.1016/j.jgr.2016.01.001_bib14) 2012; 84 Huang (10.1016/j.jgr.2016.01.001_bib21) 2014; 80 Hwang (10.1016/j.jgr.2016.01.001_bib23) 2013; 27 Hwang (10.1016/j.jgr.2016.01.001_bib18) 2013; 37 Hwang (10.1016/j.jgr.2016.01.001_bib29) 2014; 17 Fisher (10.1016/j.jgr.2016.01.001_bib8) 2009; 174 Hwang (10.1016/j.jgr.2016.01.001_bib17) 2014; 5 Lü (10.1016/j.jgr.2016.01.001_bib12) 2009; 7 Sun (10.1016/j.jgr.2016.01.001_bib32) 2015; 69 Quan (10.1016/j.jgr.2016.01.001_bib30) 2005; 280 Lee (10.1016/j.jgr.2016.01.001_bib16) 2003; 121 Afaq (10.1016/j.jgr.2016.01.001_bib27) 2002; 15 Kang (10.1016/j.jgr.2016.01.001_bib11) 2009; 123 1390183 - Br J Dermatol. 1992 Sep;127 Suppl 41:25-30 23871827 - Food Chem Toxicol. 2013 Sep;59:709-14 24233239 - J Ginseng Res. 2013 Oct;37(4):425-34 15020224 - Biochem Biophys Res Commun. 2004 Apr 2;316(2):348-55 23855516 - J Agric Food Chem. 2013 Aug 7;61(31):7599-605 12437452 - Arch Dermatol. 2002 Nov;138(11):1462-70 19420751 - Biol Pharm Bull. 2009 May;32(5):837-41 8716032 - Ostomy Wound Manage. 1996 Apr;42(3):32-4, 36, 38-40, passim 25227288 - J Nat Med. 2015 Jan;69(1):22-34 12043949 - J Clin Pharmacol. 2002 Jun;42(6):605-12 12925222 - J Invest Dermatol. 2003 Sep;121(3):607-13 23000938 - Acta Dermatovenerol Alp Pannonica Adriat. 2012;21(2):33-6 24281186 - Food Funct. 2014 Feb;5(2):265-74 23613825 - PLoS One. 2013 Apr 17;8(4):e61271 23148028 - Phytother Res. 2013 Sep;27(9):1352-7 22692056 - Biochem Pharmacol. 2012 Aug 15;84(4):532-9 20596791 - Biol Trace Elem Res. 2011 Jul;142(1):106-16 25561721 - Cold Spring Harb Perspect Med. 2015 Jan 05;5(1):a015370 19801098 - Lancet. 2009 Oct 3;374(9696):1196-208 12208239 - Ageing Res Rev. 2002 Sep;1(4):705-20 11535382 - Clin Dermatol. 2001 Jul-Aug;19(4):413-23 19601854 - Curr Vasc Pharmacol. 2009 Jul;7(3):293-302 21494373 - Immune Netw. 2011 Feb;11(1):42-9 15579469 - J Biol Chem. 2005 Mar 4;280(9):8079-85 25369199 - J Med Food. 2014 Dec;17(12):1339-49 17493734 - Food Chem Toxicol. 2007 Oct;45(10):1795-804 25867599 - Rejuvenation Res. 2015 Oct;18(5):449-57 19675548 - J Investig Dermatol Symp Proc. 2009 Aug;14(1):20-4 19517226 - Cell Mol Neurobiol. 2009 Dec;29(8):1257-64 20064225 - Trials. 2010 Jan 11;11:2 11493097 - Arch Dermatol. 2001 Aug;137(8):1043-51 23505091 - Phytother Res. 2013 Dec;27(12):1874-82 12239423 - Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):297-306 19723059 - Ann N Y Acad Sci. 2009 Aug;1171:217-27 8460510 - West J Med. 1993 Mar;158(3):279-85 19116368 - Am J Pathol. 2009 Jan;174(1):101-14 23717123 - J Ginseng Res. 2012 Jul;36(3):225-41 25019675 - J Med Food. 2014 Sep;17(9):985-95 9358139 - N Engl J Med. 1997 Nov 13;337(20):1419-28 25377118 - Planta Med. 2014 Dec;80(18):1732-8 19501277 - J Ethnopharmacol. 2009 Jun 25;123(3):446-51 20923458 - Skin Res Technol. 2010 Nov;16(4):444-9 |
| References_xml | – volume: 32 start-page: 837 year: 2009 end-page: 841 ident: bib13 article-title: Ginsenoside Rb1 suppresses ultraviolet radiation induced apoptosis by inducing DNA repair publication-title: Biol Pharm Bull – volume: 137 start-page: 1043 year: 2001 end-page: 1051 ident: bib25 article-title: Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color publication-title: Arch Dermatol – volume: 84 start-page: 532 year: 2012 end-page: 539 ident: bib14 article-title: Ginsenoside Rb1 induces type I collagen expression through peroxisome proliferator-activated receptor-delta publication-title: Biochem Pharmacol – volume: 174 start-page: 101 year: 2009 end-page: 114 ident: bib8 article-title: Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin publication-title: Am J Pathol – volume: 37 start-page: 425 year: 2013 end-page: 434 ident: bib18 article-title: Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice publication-title: J Ginseng Res – volume: 27 start-page: 1352 year: 2013 end-page: 1357 ident: bib22 article-title: Hair growth activity of publication-title: Phytother Res – volume: 5 year: 2015 ident: bib3 article-title: Natural and sun-induced aging of human skin publication-title: Cold Spring Harb Perspect Med – volume: 8 start-page: e61271 year: 2013 ident: bib35 article-title: Antifatigue effects of publication-title: PLoS One – volume: 15 start-page: 297 year: 2002 end-page: 306 ident: bib27 article-title: Photo chemo prevention by botanical antioxidants publication-title: Skin Pharmacol Appl – volume: 280 start-page: 8079 year: 2005 end-page: 8085 ident: bib30 article-title: Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts publication-title: J Biol Chem – volume: 42 year: 1996 ident: bib41 article-title: Breaking the cycle: the etiology of incontinence dermatitis and evaluating and using skin care products publication-title: Ostomy Wound Manag – volume: 27 start-page: 1874 year: 2013 end-page: 1882 ident: bib23 article-title: A comparative study of baby immature and adult shoots of Aloe vera on UVB-induced skin photoaging in vitro publication-title: Phytother Res – volume: 21 start-page: 33 year: 2012 end-page: 36 ident: bib4 article-title: Intrinsic skin aging: the role of oxidative stress publication-title: Acta Dermatovenerol Alp Panonica Adriat – volume: 7 start-page: 293 year: 2009 end-page: 302 ident: bib12 article-title: Ginseng compounds: an update on their molecular mechanisms and medical applications publication-title: Current Vascular Pharm – volume: 36 start-page: 225 year: 2012 end-page: 241 ident: bib9 article-title: Ginseng in traditional herbal prescriptions publication-title: J Ginseng Res – volume: 1171 start-page: 217 year: 2009 end-page: 227 ident: bib33 article-title: Antioxidant and apoptotic effects of Korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells publication-title: Ann N Y Acad Sci – volume: 19 start-page: 413 year: 2001 end-page: 423 ident: bib40 article-title: Cosmetics for the elderly publication-title: Clin Dermatol – volume: 138 start-page: 1462 year: 2002 end-page: 1470 ident: bib5 article-title: Mechanisms of photoaging and chronological skin aging publication-title: Arch Dermatol – volume: 121 start-page: 607 year: 2003 end-page: 613 ident: bib16 article-title: Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2 publication-title: J Invest Dermatol – volume: 17 start-page: 1339 year: 2014 end-page: 1349 ident: bib31 article-title: water extracts protect against ultraviolet B-exposed skin aging in vitro and in vivo publication-title: J Med Food – volume: 29 start-page: 1257 year: 2009 end-page: 1264 ident: bib34 article-title: The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells publication-title: Cell Mol Neurobiol – volume: 1 start-page: 57 year: 2009 end-page: 59 ident: bib28 article-title: Evaluate the effectiveness of the natural cosmetic product compared to chemical-based products publication-title: Int J Chem – volume: 69 start-page: 22 year: 2015 end-page: 34 ident: bib32 article-title: Effects of publication-title: J Nat Med – volume: 5 start-page: 265 year: 2014 end-page: 274 ident: bib17 article-title: Enzyme-modified publication-title: Food Funct – volume: 374 start-page: 1196 year: 2009 end-page: 1208 ident: bib39 article-title: Ageing populations: the challenges ahead publication-title: Lancet – volume: 11 start-page: 2 year: 2010 ident: bib26 article-title: Questionnaires in clinical trials: guidelines for optimal design and administration publication-title: Trials – volume: 316 start-page: 348 year: 2004 end-page: 355 ident: bib15 article-title: Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin publication-title: Biochem Biophys Res Commun – volume: 158 start-page: 279 year: 1993 end-page: 285 ident: bib42 article-title: Pathobiology of the stratum corneum publication-title: West J Med – volume: 123 start-page: 446 year: 2009 end-page: 451 ident: bib11 article-title: Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice publication-title: J Ethnopharmacol – volume: 45 start-page: 1795 year: 2007 end-page: 1804 ident: bib20 article-title: Effects of polyphenols derived from fruit of publication-title: Food Chem Toxicol – volume: 18 start-page: 449 year: 2015 end-page: 457 ident: bib24 article-title: Efficacy and safety of enzyme-modified publication-title: Rejuvenation Res. – volume: 61 start-page: 7599 year: 2013 end-page: 7605 ident: bib38 article-title: Effects of pectin pentaoligosaccharide from Hawthorn ( publication-title: J Agric Food Chem – volume: 59 start-page: 709 year: 2013 end-page: 714 ident: bib36 article-title: Protective effect of extract of publication-title: Food Chem Toxicol – volume: 14 start-page: 20 year: 2009 end-page: 24 ident: bib6 article-title: Matrix-degrading metalloproteinases in photoaging publication-title: J Invest Derm Symp P – volume: 142 start-page: 106 year: 2011 end-page: 116 ident: bib37 article-title: Prevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro of publication-title: Biol Trace Elem Res – volume: 11 start-page: 42 year: 2011 end-page: 49 ident: bib10 article-title: Anti-inflammatory and antioxidative effects of Korean red ginseng extract in human keratinocytes publication-title: Immune Netw – volume: 42 start-page: 605 year: 2002 end-page: 612 ident: bib19 article-title: Hawthorn publication-title: J Clin Pharmacol – volume: 1 start-page: 705 year: 2002 end-page: 720 ident: bib7 article-title: UV-light-induced signal cascades and skin aging publication-title: Ageing Res Rev – volume: 17 start-page: 985 year: 2014 end-page: 995 ident: bib29 article-title: Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression publication-title: J Med Food – volume: 127 start-page: 25 year: 1992 end-page: 30 ident: bib1 article-title: Ageing and photoaging of the skin: observations at the cellular and molecular level publication-title: Br J Dermatol – volume: 337 start-page: 1419 year: 1997 end-page: 1428 ident: bib2 article-title: Pathophysiology of premature skin aging induced by ultraviolet light publication-title: N Engl J Med – volume: 2 start-page: 189 year: 2010 end-page: 194 ident: bib43 article-title: Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods publication-title: Skin Res Technol – volume: 80 start-page: 1732 year: 2014 end-page: 1738 ident: bib21 article-title: Antioxidant and tyrosinase inhibitory effects of neolignan glycosides from publication-title: Planta Med – volume: 123 start-page: 446 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib11 article-title: Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2009.03.022 – volume: 61 start-page: 7599 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib38 article-title: Effects of pectin pentaoligosaccharide from Hawthorn (Crataegus pinnatifida Bunge. var. Major) on the activity and mRNA levels of enzymes involved in fatty acid oxidation in the liver of mice fed a high-fat diet publication-title: J Agric Food Chem doi: 10.1021/jf400283w – volume: 37 start-page: 425 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib18 article-title: Enzyme-processed Korean Red Ginseng extracts protects against skin damage induced by UVB irradiation in hairless mice publication-title: J Ginseng Res doi: 10.5142/jgr.2013.37.425 – volume: 174 start-page: 101 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib8 article-title: Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin publication-title: Am J Pathol doi: 10.2353/ajpath.2009.080599 – volume: 17 start-page: 985 year: 2014 ident: 10.1016/j.jgr.2016.01.001_bib29 article-title: Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoaging of skin by regulation of procollagen type I and MMP-1 expression publication-title: J Med Food doi: 10.1089/jmf.2013.2999 – volume: 374 start-page: 1196 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib39 article-title: Ageing populations: the challenges ahead publication-title: Lancet doi: 10.1016/S0140-6736(09)61460-4 – volume: 121 start-page: 607 year: 2003 ident: 10.1016/j.jgr.2016.01.001_bib16 article-title: Ginsenoside F1 protects human HaCaT keratinocytes from ultraviolet-B-induced apoptosis by maintaining constant levels of Bcl-2 publication-title: J Invest Dermatol doi: 10.1046/j.1523-1747.2003.12425.x – volume: 8 start-page: e61271 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib35 article-title: Antifatigue effects of Panax ginseng C.A. Meyer: a randomised, double-blind, placebo-controlled trial publication-title: PLoS One doi: 10.1371/journal.pone.0061271 – volume: 142 start-page: 106 year: 2011 ident: 10.1016/j.jgr.2016.01.001_bib37 article-title: Prevention effect in selenite-induced cataract in vivo and antioxidative effects in vitro of Crataegus pinnatifida leaves publication-title: Biol Trace Elem Res doi: 10.1007/s12011-010-8752-8 – volume: 127 start-page: 25 year: 1992 ident: 10.1016/j.jgr.2016.01.001_bib1 article-title: Ageing and photoaging of the skin: observations at the cellular and molecular level publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.1992.tb16984.x – volume: 84 start-page: 532 year: 2012 ident: 10.1016/j.jgr.2016.01.001_bib14 article-title: Ginsenoside Rb1 induces type I collagen expression through peroxisome proliferator-activated receptor-delta publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2012.05.023 – volume: 15 start-page: 297 year: 2002 ident: 10.1016/j.jgr.2016.01.001_bib27 article-title: Photo chemo prevention by botanical antioxidants publication-title: Skin Pharmacol Appl doi: 10.1159/000064533 – volume: 27 start-page: 1874 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib23 article-title: A comparative study of baby immature and adult shoots of Aloe vera on UVB-induced skin photoaging in vitro publication-title: Phytother Res doi: 10.1002/ptr.4943 – volume: 1 start-page: 705 year: 2002 ident: 10.1016/j.jgr.2016.01.001_bib7 article-title: UV-light-induced signal cascades and skin aging publication-title: Ageing Res Rev doi: 10.1016/S1568-1637(02)00024-7 – volume: 280 start-page: 8079 year: 2005 ident: 10.1016/j.jgr.2016.01.001_bib30 article-title: Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in human skin fibroblasts publication-title: J Biol Chem doi: 10.1074/jbc.M409647200 – volume: 1 start-page: 57 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib28 article-title: Evaluate the effectiveness of the natural cosmetic product compared to chemical-based products publication-title: Int J Chem doi: 10.5539/ijc.v1n2p57 – volume: 158 start-page: 279 year: 1993 ident: 10.1016/j.jgr.2016.01.001_bib42 article-title: Pathobiology of the stratum corneum publication-title: West J Med – volume: 11 start-page: 42 year: 2011 ident: 10.1016/j.jgr.2016.01.001_bib10 article-title: Anti-inflammatory and antioxidative effects of Korean red ginseng extract in human keratinocytes publication-title: Immune Netw doi: 10.4110/in.2011.11.1.42 – volume: 337 start-page: 1419 year: 1997 ident: 10.1016/j.jgr.2016.01.001_bib2 article-title: Pathophysiology of premature skin aging induced by ultraviolet light publication-title: N Engl J Med doi: 10.1056/NEJM199711133372003 – volume: 138 start-page: 1462 year: 2002 ident: 10.1016/j.jgr.2016.01.001_bib5 article-title: Mechanisms of photoaging and chronological skin aging publication-title: Arch Dermatol doi: 10.1001/archderm.138.11.1462 – volume: 42 start-page: 605 year: 2002 ident: 10.1016/j.jgr.2016.01.001_bib19 article-title: Hawthorn publication-title: J Clin Pharmacol doi: 10.1177/00970002042006003 – volume: 59 start-page: 709 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib36 article-title: Protective effect of extract of Crataegus pinnatifida pollen on DNA damage response to oxidative stress publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2013.07.015 – volume: 316 start-page: 348 year: 2004 ident: 10.1016/j.jgr.2016.01.001_bib15 article-title: Compound K induces expression of hyaluronan synthase 2 gene in transformed human keratinocytes and increases hyaluronan in hairless mouse skin publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2004.02.046 – volume: 69 start-page: 22 year: 2015 ident: 10.1016/j.jgr.2016.01.001_bib32 article-title: Effects of Galla chinensis extracts on UVB-irradiated MMP-1 production in hairless mice publication-title: J Nat Med – volume: 14 start-page: 20 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib6 article-title: Matrix-degrading metalloproteinases in photoaging publication-title: J Invest Derm Symp P doi: 10.1038/jidsymp.2009.8 – volume: 1171 start-page: 217 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib33 article-title: Antioxidant and apoptotic effects of Korean white ginseng extracted with the same ratio of protopanaxadiol and protopanaxatriol saponins in human hepatoma HepG2 cells publication-title: Ann N Y Acad Sci doi: 10.1111/j.1749-6632.2009.04918.x – volume: 21 start-page: 33 year: 2012 ident: 10.1016/j.jgr.2016.01.001_bib4 article-title: Intrinsic skin aging: the role of oxidative stress publication-title: Acta Dermatovenerol Alp Panonica Adriat – volume: 27 start-page: 1352 year: 2013 ident: 10.1016/j.jgr.2016.01.001_bib22 article-title: Hair growth activity of Crataegus pinnatifida on C57BL/6 mouse model publication-title: Phytother Res doi: 10.1002/ptr.4870 – volume: 11 start-page: 2 year: 2010 ident: 10.1016/j.jgr.2016.01.001_bib26 article-title: Questionnaires in clinical trials: guidelines for optimal design and administration publication-title: Trials doi: 10.1186/1745-6215-11-2 – volume: 5 start-page: 265 year: 2014 ident: 10.1016/j.jgr.2016.01.001_bib17 article-title: Enzyme-modified Panax ginseng inhibits UVB-induced skin aging through the regulation of procollagen type I and MMP-1 expression publication-title: Food Funct doi: 10.1039/C3FO60418G – volume: 36 start-page: 225 year: 2012 ident: 10.1016/j.jgr.2016.01.001_bib9 article-title: Ginseng in traditional herbal prescriptions publication-title: J Ginseng Res doi: 10.5142/jgr.2012.36.3.225 – volume: 5 year: 2015 ident: 10.1016/j.jgr.2016.01.001_bib3 article-title: Natural and sun-induced aging of human skin publication-title: Cold Spring Harb Perspect Med doi: 10.1101/cshperspect.a015370 – volume: 19 start-page: 413 year: 2001 ident: 10.1016/j.jgr.2016.01.001_bib40 article-title: Cosmetics for the elderly publication-title: Clin Dermatol doi: 10.1016/S0738-081X(01)00181-X – volume: 80 start-page: 1732 year: 2014 ident: 10.1016/j.jgr.2016.01.001_bib21 article-title: Antioxidant and tyrosinase inhibitory effects of neolignan glycosides from Crataegus pinnatifida seeds publication-title: Planta Med doi: 10.1055/s-0034-1383253 – volume: 17 start-page: 1339 year: 2014 ident: 10.1016/j.jgr.2016.01.001_bib31 article-title: Vigna angularis water extracts protect against ultraviolet B-exposed skin aging in vitro and in vivo publication-title: J Med Food doi: 10.1089/jmf.2013.3017 – volume: 7 start-page: 293 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib12 article-title: Ginseng compounds: an update on their molecular mechanisms and medical applications publication-title: Current Vascular Pharm doi: 10.2174/157016109788340767 – volume: 32 start-page: 837 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib13 article-title: Ginsenoside Rb1 suppresses ultraviolet radiation induced apoptosis by inducing DNA repair publication-title: Biol Pharm Bull doi: 10.1248/bpb.32.837 – volume: 18 start-page: 449 year: 2015 ident: 10.1016/j.jgr.2016.01.001_bib24 article-title: Efficacy and safety of enzyme-modified Panax ginseng for anti-wrinkle therapy in healthy skin: a single-center, randomized, double-blind, placebo-controlled study publication-title: Rejuvenation Res. doi: 10.1089/rej.2015.1660 – volume: 29 start-page: 1257 year: 2009 ident: 10.1016/j.jgr.2016.01.001_bib34 article-title: The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells publication-title: Cell Mol Neurobiol doi: 10.1007/s10571-009-9421-3 – volume: 42 year: 1996 ident: 10.1016/j.jgr.2016.01.001_bib41 article-title: Breaking the cycle: the etiology of incontinence dermatitis and evaluating and using skin care products publication-title: Ostomy Wound Manag – volume: 45 start-page: 1795 year: 2007 ident: 10.1016/j.jgr.2016.01.001_bib20 article-title: Effects of polyphenols derived from fruit of Crataegus pinnatifida on cell transformation, dermal edema and skin tumor formation by phorbol ester application publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2007.03.016 – volume: 137 start-page: 1043 year: 2001 ident: 10.1016/j.jgr.2016.01.001_bib25 article-title: Cutaneous photodamage in Koreans: influence of sex, sun exposure, smoking, and skin color publication-title: Arch Dermatol – volume: 2 start-page: 189 year: 2010 ident: 10.1016/j.jgr.2016.01.001_bib43 article-title: Efficacy of anti-wrinkle products in skin surface appearance: a comparative study using non-invasive methods publication-title: Skin Res Technol – reference: 23148028 - Phytother Res. 2013 Sep;27(9):1352-7 – reference: 21494373 - Immune Netw. 2011 Feb;11(1):42-9 – reference: 23000938 - Acta Dermatovenerol Alp Pannonica Adriat. 2012;21(2):33-6 – reference: 15579469 - J Biol Chem. 2005 Mar 4;280(9):8079-85 – reference: 12925222 - J Invest Dermatol. 2003 Sep;121(3):607-13 – reference: 23505091 - Phytother Res. 2013 Dec;27(12):1874-82 – reference: 17493734 - Food Chem Toxicol. 2007 Oct;45(10):1795-804 – reference: 24233239 - J Ginseng Res. 2013 Oct;37(4):425-34 – reference: 19116368 - Am J Pathol. 2009 Jan;174(1):101-14 – reference: 23855516 - J Agric Food Chem. 2013 Aug 7;61(31):7599-605 – reference: 19723059 - Ann N Y Acad Sci. 2009 Aug;1171:217-27 – reference: 20064225 - Trials. 2010 Jan 11;11:2 – reference: 8460510 - West J Med. 1993 Mar;158(3):279-85 – reference: 23613825 - PLoS One. 2013 Apr 17;8(4):e61271 – reference: 1390183 - Br J Dermatol. 1992 Sep;127 Suppl 41:25-30 – reference: 20923458 - Skin Res Technol. 2010 Nov;16(4):444-9 – reference: 20596791 - Biol Trace Elem Res. 2011 Jul;142(1):106-16 – reference: 25227288 - J Nat Med. 2015 Jan;69(1):22-34 – reference: 23871827 - Food Chem Toxicol. 2013 Sep;59:709-14 – reference: 15020224 - Biochem Biophys Res Commun. 2004 Apr 2;316(2):348-55 – reference: 12239423 - Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):297-306 – reference: 12208239 - Ageing Res Rev. 2002 Sep;1(4):705-20 – reference: 25377118 - Planta Med. 2014 Dec;80(18):1732-8 – reference: 19501277 - J Ethnopharmacol. 2009 Jun 25;123(3):446-51 – reference: 12437452 - Arch Dermatol. 2002 Nov;138(11):1462-70 – reference: 19420751 - Biol Pharm Bull. 2009 May;32(5):837-41 – reference: 23717123 - J Ginseng Res. 2012 Jul;36(3):225-41 – reference: 9358139 - N Engl J Med. 1997 Nov 13;337(20):1419-28 – reference: 24281186 - Food Funct. 2014 Feb;5(2):265-74 – reference: 11535382 - Clin Dermatol. 2001 Jul-Aug;19(4):413-23 – reference: 8716032 - Ostomy Wound Manage. 1996 Apr;42(3):32-4, 36, 38-40, passim – reference: 22692056 - Biochem Pharmacol. 2012 Aug 15;84(4):532-9 – reference: 25561721 - Cold Spring Harb Perspect Med. 2015 Jan 05;5(1):a015370 – reference: 19601854 - Curr Vasc Pharmacol. 2009 Jul;7(3):293-302 – reference: 25369199 - J Med Food. 2014 Dec;17(12):1339-49 – reference: 19517226 - Cell Mol Neurobiol. 2009 Dec;29(8):1257-64 – reference: 19801098 - Lancet. 2009 Oct 3;374(9696):1196-208 – reference: 25019675 - J Med Food. 2014 Sep;17(9):985-95 – reference: 25867599 - Rejuvenation Res. 2015 Oct;18(5):449-57 – reference: 19675548 - J Investig Dermatol Symp Proc. 2009 Aug;14(1):20-4 – reference: 12043949 - J Clin Pharmacol. 2002 Jun;42(6):605-12 – reference: 11493097 - Arch Dermatol. 2001 Aug;137(8):1043-51 |
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| Snippet | Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB... BACKGROUNDHuman skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging,... Background: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging,... |
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| SubjectTerms | antiaging antioxidants antiwrinkle clinical study collagen Crataegus pinnatifida fibroblasts humans interstitial collagenase irradiation Oriental traditional medicine Panax ginseng photoaging roughness secretion skin (animal) Western blotting 기타의약학 |
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| Title | Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin |
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