Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis

• Published in: Journal of psychiatric research Vol. 45; no. 8; pp. 995 - 1004
• Main Authors: Fernandes, Brisa Simões, Gama, Clarissa Severino, Maria Ceresér, Keila, Yatham, Lakshmi N., Fries, Gabriel Rodrigo, Colpo, Gabriela, de Lucena, David, Kunz, Mauricio, Gomes, Fabiano Alves, Kapczinski, Flavio
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.08.2011; Elsevier
• Subjects: Adult and adolescent clinical studies; Antidepressive Agents - therapeutic use; BDNF; Biological and medical sciences; Biological markers; Biomarker; Bipolar affective disorder; Bipolar disorder; Bipolar Disorder - blood; Bipolar Disorder - classification; Bipolar Disorder - diagnosis; Bipolar Disorder - drug therapy; Bipolar disorders; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - blood; Databases, Factual - statistics & numerical data; Depression; Humans; Mania; Medical sciences; Meta-analysis; Mood disorders; Mood state; Moods; Nervous system; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Regression Analysis; Bipolar disorder; Biomarker; Mood state; Brain-derived neurotrophic factor; BDNF; Meta-analysis; Mood disorder; Affect affectivity; Biological marker; Regression analysis; Review; Metaanalysis; Mood; Brain derived neurotrophic factor

Brain-derived neurotrophic factor (BDNF) plays a central role in synaptic plasticity and neurogenesis. Bipolar disorder (BD) is among the most disabling of all psychiatric disorders and is associated with poor outcomes. Some studies suggest that BDNF levels decrease during mood states and remain nor...