The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa

• Published in: eLife Vol. 6
• Main Authors: Riehle, Michelle M, Bukhari, Tullu, Gneme, Awa, Guelbeogo, Wamdaogo M, Coulibaly, Boubacar, Fofana, Abdrahamane, Pain, Adrien, Bischoff, Emmanuel, Renaud, Francois, Beavogui, Abdoul H, Traore, Sekou F, Sagnon, N’Fale, Vernick, Kenneth D
• Format: Journal Article
• Language: English
• Published: England eLife Science Publications, Ltd 23.06.2017; eLife Sciences Publications Ltd; eLife Sciences Publication; eLife Sciences Publications, Ltd
• Subjects: Africa; Alleles; Animals; Anopheles; Anopheles - genetics; Anopheles - parasitology; Anopheles gambiae; Behavior, Animal; Chromosome Inversion; chromosome rearrangement; Chromosomes; Chromosomes, Insect; Culicidae; Disease susceptibility; Disease transmission; Epidemiology and Global Health; Gene expression; Gene polymorphism; Genetic aspects; Genomics and Evolutionary Biology; Geography; Health aspects; Host-Parasite Interactions; host-pathogen interactions; Humans; insect vector; Insecticides; Inversion; Life Sciences; Malaria; Malaria - transmission; Microbiology and Parasitology; Mosquito Vectors - genetics; Mosquito Vectors - parasitology; Mosquitoes; Observations; Parasites; Parasitology; Plasmodium; Plasmodium falciparum; Plasmodium falciparum - growth & development; Population genetics; Recombination; Vectors; Africa; Kenya; West Africa; global health; Plasmodium; epidemiology; Anopheles; host-pathogen interactions; insect vector; evolutionary biology; chromosome rearrangement; genomics; malaria

Chromosome inversions suppress genetic recombination and establish co-adapted gene complexes, or supergenes. The 2La inversion is a widespread polymorphism in the Anopheles gambiae species complex, the major African mosquito vectors of human malaria. Here we show that alleles of the 2La inversion ar...