Advanced endoscopic features of ulcerative colitis-associated neoplasias: Quantification of autofluorescence imaging

• Published in: International journal of oncology Vol. 48; no. 2; pp. 551 - 558
• Main Authors: YOSHIOKA, SHINICHIRO, MITSUYAMA, KEIICHI, TAKEDATSU, HIDETOSHI, KUWAKI, KOTARO, YAMAUCHI, RYOSUKE, YAMASAKI, HIROSHI, FUKUNAGA, SHUHEI, AKIBA, JUN, KINUGASA, TETSUSHI, AKAGI, YOSHITO, TSURUTA, OSAMU, TORIMURA, TAKUJI
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.02.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Adult; Aged; autofluorescence imaging; Biopsy; Cancer; Colitis, Ulcerative - pathology; Colon - pathology; Colonoscopy; Colonoscopy - methods; Colorectal cancer; Colorectal Neoplasms - pathology; Diagnosis; Endoscopy; Female; Gastrointestinal tumors; Humans; Inflammation; Inflammatory bowel disease; Innovations; Male; Methods; Middle Aged; Molecular diagnostic techniques; Optical Imaging - methods; Physiological aspects; Pilot Projects; Retrospective Studies; Software; Surveillance; Ulcerative colitis
• ISSN: 1019-6439; 1791-2423
• DOI: 10.3892/ijo.2015.3284

Ulcerative colitis (UC) patients are well known to carry a higher risk of developing colorectal dysplasia/cancer. However, it is hard to detect the lesion in the early phase during colonoscopy. This pilot study was conducted to analyze the endoscopic characteristics of neoplastic lesions associated with UC using advanced imaging techniques. This is a retrospective analysis of 15 colorectal neoplastic lesion obtained from 11 UC patients during remission who underwent white-light-and advanced endoscopic imaging techniques, including chromoendoscopy, narrow-band imaging and autofluorescence imaging (AFI), and were treated with surgery. These lesions were analyzed for histology, location, size, shape, color and endoscopic features. The green/red ratio was also assessed to quantify the AFI intensity. All 11 patients had extensive colitis with the median disease duration of 14.0 years. A total of 15 lesions, consisting of 8 high-grade dysplasia and 7 cancer, was mostly located in the distal colon (86.7%, 13/15) with the mean size of 8.6 mm. The shape was protruding in 46.7% (7/15), flat elevated in 40.0% (6/15) and flat in 13.3% (2/15) and the color was red in 60.0% (9/15), same colored in 33.3% (5/15) and discolored in 6.7% (1/15). The lesion predominantly showed Kudo's neoplastic pit pattern in 86.7% (13/15; 5 type IIIL, 7 type IV and 1 type VI) on chromoendoscopy and Sano's neoplastic capillary pattern (type IIIa) in 63.6% (7/11) on narrow-band imaging, but were colored purple as neoplastic lesions in only 37.5% (3/8) on AFI. Of note, the AFI green/red ratio was significantly lower in the neoplastic lesions than UC-involved areas (p=0.00014) and UC-uninvolved areas (p=0.00651) irrespective of the lesion's size and histological type. In conclusion, endoscopic analysis based on advanced imaging, in particular AFI quantitation, may be helpful to detect early stage neoplastic lesions in long standing UC. Large-scale, prospective studies are needed.