Effect of telavancin on human intestinal microflora

• Published in: International journal of antimicrobial agents Vol. 38; no. 6; pp. 474 - 479
• Main Authors: Rashid, Mamun-Ur, Weintraub, Andrej, Nord, Carl Erik
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.12.2011; Elsevier
• Subjects: Adolescent; Adult; Aminoglycosides - administration & dosage; Aminoglycosides - pharmacokinetics; Aminoglycosides - pharmacology; anthropogenic activities; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria - drug effects; Bacteroides; Bifidobacterium; Biological and medical sciences; body weight; Candida albicans; cell walls; Clostridium difficile; Drug Resistance, Bacterial - drug effects; Ecological impact; Ecosystem; Enterobacteriaceae; Enterococcus; feces; Feces - chemistry; Feces - microbiology; Female; females; Gram-positive bacteria; Human intestinal microflora; Humans; Infectious Disease; intestinal microorganisms; Intestines - drug effects; Intestines - microbiology; intravenous injection; Lactobacillus; Male; males; mechanism of action; Medical sciences; Microbial Sensitivity Tests; minimum inhibitory concentration; pharmacokinetics; Pharmacology. Drug treatments; plasma membrane; selective media; Telavancin; toxins; urine; Young Adult; Telavancin; Human intestinal microflora; Ecological impact; Human; Antibiotic; Digestive system; Gut; Microflora; Antibacterial agent

Telavancin is a new lipoglycopeptide antibiotic for the treatment of Gram-positive infections. It has a dual mechanism of action by inhibiting bacterial cell wall synthesis and disrupting the bacterial plasma membrane. The purpose of the present study was to investigate the effect of administration...