Hierarchical assembly of presynaptic components in defined C. elegans synapses

• Published in: Nature neuroscience Vol. 9; no. 12; pp. 1488 - 1498
• Main Authors: Shen, Kang, Patel, Maulik R, Lehrman, Emily K, Poon, Vivian Y, Crump, Justin G, Zhen, Mei, Bargmann, Cornelia I
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.12.2006
• Subjects: Animals; Caenorhabditis elegans; Caenorhabditis elegans - genetics; Caenorhabditis elegans - metabolism; Caenorhabditis elegans Proteins - genetics; Caenorhabditis elegans Proteins - metabolism; Cytoskeleton - metabolism; Genetic aspects; Heparan sulfate; Immunoglobulins - metabolism; Kinases; Membrane proteins; Motor Neurons - metabolism; Mutation; Nerve Tissue Proteins - metabolism; Phosphoproteins - genetics; Phosphoproteins - metabolism; Physiological aspects; Presynaptic Terminals - metabolism; Proteins; Synapses; United States; New York; United States > US; California

The presynaptic regions of axons accumulate synaptic vesicles, active zone proteins and periactive zone proteins. However, the rules for orderly recruitment of presynaptic components are not well understood. We systematically examined molecular mechanisms of presynaptic development in egg-laying syn...