Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice - Tao, Yuyong; Mis, Monika; Blazer, Levi; Ustav, Mart; Steinhart, Zachary; Chidiac, Rony; Kubarakos, Elli; O'Brien, Siobhan; Wang, Xiaomei; Jarvik, Nick; Patel, Nish; Adams, Jarrett; et al. (eLife, 2019)
Keywords: Animals; Antibodies; Antibodies - metabolism; antibody; Biochemistry and Chemical Biology; Cell Line; Cell receptors; Cells (Biology); Developmental Biology; frizzled; Frizzled Receptors - agonists; Homeostasis; Humans; Low Density Lipoprotein Receptor-Related Protein-5 - agonists; Low Density Lipoprotein Receptor-Related Protein-6 - agonists; Mice; organoid; Organoids - drug effects; Organoids - growth & development; Physiological aspects; pluripotent stem cell; Pluripotent Stem Cells - drug effects; Pluripotent Stem Cells - physiology; Protein Binding; Proteins; regenerative medicine; Stem cells; Therapeutics; Tools and Resources; Wnt; Wnt proteins; Wnt Signaling Pathway - drug effects; Canada; mouse; antibody; chemical biology; frizzled; developmental biology; pluripotent stem cell; regenerative medicine; biochemistry; Wnt; organoid