Defining the molecular response to ischemia-reperfusion injury and remote ischemic preconditioning in human kidney transplantation

• Published in: PloS one Vol. 19; no. 10; p. e0311613
• Main Authors: Nordström, Johan, Badia-I-Mompel, Pau, Witasp, Anna, Schwarz, Angelina, Evenepoel, Pieter, Moor, Matthias B., Wennberg, Lars, Saez-Rodriguez, Julio, Wernerson, Annika, Olauson, Hannes
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.10.2024
• Subjects: Adult; Analysis; Biology and Life Sciences; Biopsy; Care and treatment; Clinical trials; Diagnosis; Diagnosis, Noninvasive; Donation of organs, tissues, etc; Epidermal growth factor; Epidermal growth factor receptors; Female; Genetic aspects; Genetic transcription; Growth factors; Health aspects; Humans; Impact analysis; Injury analysis; Ischemia; Ischemic Preconditioning - methods; Kidney - metabolism; Kidney transplantation; Kidney Transplantation - adverse effects; Kidney transplants; Kidneys; Kinases; Kynurenine - blood; Kynurenine - metabolism; Living Donors; Male; MAP kinase; Mass spectrometry; Medicine and Health Sciences; Metabolites; Methods; Middle Aged; Organ donors; Preconditioning; Protein kinases; Renal failure; Reperfusion; Reperfusion injury; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Scientific imaging; Surgery; Transcriptome; Transcriptomes; Transcriptomics; Transplantation; United Arab Emirates

Ischemia-reperfusion injury (IRI) inevitably occurs during kidney transplantation and extended ischemia is associated with delayed graft function and poor outcomes. Remote ischemic preconditioning (RIPC) is a simple, noninvasive procedure aimed at reducing IRI and improving graft function. Experimen...