Monocyte tissue factor expression is enhanced in women who smoke and use oral contraceptives

• Published in: Thrombosis and haemostasis Vol. 82; no. 6; p. 1614
• Main Authors: Hölschermann, H, Terhalle, H M, Zakel, U, Maus, U, Parviz, B, Tillmanns, H, Haberbosch, W
• Format: Journal Article
• Language: English
• Published: Germany 01.12.1999
• Subjects: Adolescent; Adult; Contraceptives, Oral - adverse effects; Female; Humans; Middle Aged; Monocytes - metabolism; Premenopause; Smoking - adverse effects; Thromboplastin - biosynthesis; Thrombosis - etiology

The association between use of oral contraceptives (OCs) and increased risk of thromboembolic disease has been firmly established. This risk increases when use of OCs is combined with cigarette smoking. The cellular mechanism favoring an hypercoagulable state under these behaviours is not known. Cir...