Gefarnate stimulates mucin-like glycoprotein secretion in conjunctival tissue and ameliorates corneal epithelial damage in animal dry-eye models

• Published in: Clinical ophthalmology (Auckland, N.Z.) Vol. 7; no. default; pp. 211 - 217
• Main Authors: Dota, Atsuyoshi, Takaoka-Shichijo, Yuko, Nakamura, Masatsugu
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2013; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: cat; Cornea; Development and progression; Dosage and administration; Drug therapy; dry eye; Dry eye syndromes; fluorescein staining; gefarnate; Glycoproteins; Ophthalmic drugs; Original Research; Permeability; Physiological aspects; rabbit; rose bengal permeability; Japan; fluorescein staining; rose bengal permeability; dry eye; gefarnate; cat; rabbit

The aim of this study was to evaluate the effect of gefarnate on mucin-like glycoprotein secretion in isolated rabbit conjunctival tissue, and on corneal epithelial damage in rabbit and cat dry-eye models. Conjunctival tissue isolated from rabbits was treated with gefarnate. Mucin-like glycoprotein...