A systematic review of the international prevalence of BRCA mutation in breast cancer

• Published in: Clinical epidemiology Vol. 11; pp. 543 - 561
• Main Authors: Armstrong, Nigel, Ryder, Steve, Forbes, Carol, Ross, Janine, Quek, Ruben GW
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.07.2019; Dove; Dove Medical Press
• Subjects: BRCA1; BRCA2; Breast cancer; Cancer metastasis; Cancer research; Chemotherapy; Conferences and conventions; Epidermal growth factors; Estrogens; Genetic aspects; Hormones; Olaparib; Pharmaceutical industry; Phenols (Class of compounds); prevalence; Review; systematic review; South Korea; United States; Texas; United Kingdom; Australia; Germany; Spain; prevalence; BRCA1; BRCA2; systematic review; chemotherapy

A systematic review was conducted, summarizing international or ( ) mutation prevalence in breast cancer. Databases (eg, Medline and Embase; N=7) and conferences were searched (January 2012 to December 2017). From 17,872 records, 70 studies were included. In 58 large (N>100) studies, mutation pre...