Ciprofloxacin Dosage and Emergence of Resistance in Human Commensal Bacteria

• Published in: The Journal of infectious diseases Vol. 200; no. 3; pp. 390 - 398
• Main Authors: Fantin, Bruno, Duval, Xavier, Massias, Laurent, Alavoine, Loubna, Chau, Françcoise, Retout, Sylvie, Andremont, Antoine, Mentré, France
• Format: Journal Article
• Language: English
• Published: Oxford The University of Chicago Press 01.08.2009; University of Chicago Press; Oxford University Press
• Subjects: Adult; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria; Bacteriology; Bioinformatics; Biological and medical sciences; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Ciprofloxacin - pharmacology; Commensals; Computer Science; Dosage; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli - drug effects; Fecal flora; Feces - microbiology; Female; Flora; Fluoroquinolones; Fundamental and applied biological sciences. Psychology; Humans; Infectious diseases; Life Sciences; Male; Medical sciences; Microbial Sensitivity Tests; Microbiology; Miscellaneous; Pharmacokinetics; Pharynx - microbiology; Quantitative Methods; Saliva; Saliva - metabolism; Viridans Streptococci - drug effects; Volunteerism; Young Adult; Human; Infection; Resistance; Fluoroquinolone derivatives; Microbiology; Bacteria; Antibacterial agent; Ciprofloxacin; Quinolone derivatives

Background Although optimization of the fluoroquinolone dosage increases the efficacy of this class of drugs against bacterial infections, its impact on the emergence of resistance in commensal bacteria is unknown. Methods Six different 14-day dosages of oral ciprofloxacin were randomly assigned to...