Functional Characterization of Wild-type and 49 CYP2D6 Allelic Variants for N-Desmethyltamoxifen 4-Hydroxylation Activity - Muroi, Yuka; Saito, Takahiro; Takahashi, Masamitsu; Sakuyama, Kanako; Niinuma, Yui; Ito, Miyabi; Tsukada, Chiharu; Ohta, Kiminori; Endo, Yasuyuki; Oda, Akifumi; Hirasawa, Noriyasu; Hiratsuka, Masahiro (DRUG METABOLISM AND PHARMACOKINETICS, 2014)
Keywords: Alleles; Animals; Biocatalysis; Cercopithecus aethiops; Cloning, Molecular; COS Cells; CYP2D6; Cytochrome P-450 CYP2D6 - genetics; Cytochrome P-450 CYP2D6 - metabolism; cytochrome P450; drug metabolism; genetic polymorphisms; Genetic Variation - genetics; Humans; Hydroxylation - genetics; Kinetics; pharmacogenomics; tamoxifen; Tamoxifen - analogs & derivatives; Tamoxifen - chemistry; Tamoxifen - metabolism; pharmacogenomics; cytochrome P450; genetic polymorphisms; CYP2D6; tamoxifen; drug metabolism