The utility of FDG-PET in the diagnosis of thymic epithelial tumors
In this article, seven studies evaluating the utility of FDG-PET in the diagnosis of thymic epithelial tumors were reviewed and the results of an investigation conducted in Tokushima University Hospital are reported. FDG accumulation of low-risk thymoma is low, and FDG accumulation of thymic carcino...
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| Published in | The Journal of Medical Investigation Vol. 59; no. 3.4; pp. 225 - 234 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
Japan
The University of Tokushima Faculty of Medicine
2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1343-1420 1349-6867 |
| DOI | 10.2152/jmi.59.225 |
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| Abstract | In this article, seven studies evaluating the utility of FDG-PET in the diagnosis of thymic epithelial tumors were reviewed and the results of an investigation conducted in Tokushima University Hospital are reported. FDG accumulation of low-risk thymoma is low, and FDG accumulation of thymic carcinoma is high. High-risk thymoma exhibits various degrees of accumulation and a definite conclusion has not yet been reached; however, overall, the higher the histological grade, the higher the FDG accumulation becomes, suggesting that this is correlated to staging. Our data also support the previous reports. FDG-PET may indicate lymph node metastasis and distant metastasis, which are sometimes difficult to detect using other modalities. When lymph node metastasis and/or distant metastasis are suspected in addition to thymic lesions, FDG-PET/CT, which allows for searching of the entire body at once, is useful. FDG-PET/CT is effective for estimating histopathological malignancy and staging in the diagnosis of thymic epithelial tumors and can be an important imaging test with high relevance to the prognosis of a patient. J. Med. Invest. 59: 225-234, August, 2012 |
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| AbstractList | In this article, seven studies evaluating the utility of FDG-PET in the diagnosis of thymic epithelial tumors were reviewed and the results of an investigation conducted in Tokushima University Hospital are reported. FDG accumulation of low-risk thymoma is low, and FDG accumulation of thymic carcinoma is high. High-risk thymoma exhibits various degrees of accumulation and a definite conclusion has not yet been reached; however, overall, the higher the histological grade, the higher the FDG accumulation becomes, suggesting that this is correlated to staging. Our data also support the previous reports. FDG-PET may indicate lymph node metastasis and distant metastasis, which are sometimes difficult to detect using other modalities. When lymph node metastasis and/or distant metastasis are suspected in addition to thymic lesions, FDG-PET/CT, which allows for searching of the entire body at once, is useful. FDG-PET/CT is effective for estimating histopathological malignancy and staging in the diagnosis of thymic epithelial tumors and can be an important imaging test with high relevance to the prognosis of a patient. J. Med. Invest. 59: 225-234, August, 2012 In this article, seven studies evaluating the utility of FDG-PET in the diagnosis of thymic epithelial tumors were reviewed and the results of an investigation conducted in Tokushima University Hospital are reported. FDG accumulation of low-risk thymoma is low, and FDG accumulation of thymic carcinoma is high. High-risk thymoma exhibits various degrees of accumulation and a definite conclusion has not yet been reached; however, overall, the higher the histological grade, the higher the FDG accumulation becomes, suggesting that this is correlated to staging. Our data also support the previous reports. FDG-PET may indicate lymph node metastasis and distant metastasis, which are sometimes difficult to detect using other modalities. When lymph node metastasis and/or distant metastasis are suspected in addition to thymic lesions, FDG-PET/CT, which allows for searching of the entire body at once, is useful. FDG-PET/CT is effective for estimating histopathological malignancy and staging in the diagnosis of thymic epithelial tumors and can be an important imaging test with high relevance to the prognosis of a patient. |
| Author | Otsuka, Hideki |
| Author_xml | – sequence: 1 fullname: Otsuka, Hideki organization: Department of Medical Imaging, Institute of Health Biosciences, Tokushima University Graduate School |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23037192$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_icvts_ivu068 crossref_primary_10_1016_j_nrleng_2016_04_007 crossref_primary_10_1007_s00595_018_1712_1 crossref_primary_10_1016_j_cpet_2014_06_002 crossref_primary_10_1016_j_nrl_2016_04_001 crossref_primary_10_1016_j_thorsurg_2018_12_007 crossref_primary_10_12659_PJR_892105 crossref_primary_10_1007_s00464_013_3233_8 crossref_primary_10_5761_atcs_oa_16_00205 crossref_primary_10_1159_000455190 crossref_primary_10_1016_j_lungcan_2013_08_003 crossref_primary_10_4236_crcm_2014_36079 crossref_primary_10_1016_j_lungcan_2014_08_008 crossref_primary_10_1007_s11604_023_01497_w |
| Cites_doi | 10.1016/j.lungcan.2008.01.003 10.3348/kjr.2003.4.1.46 10.1016/j.ejcts.2010.09.009 10.1007/s00259-009-1082-4 10.1002/jmri.22377 10.1016/j.ejrad.2010.08.010 10.1016/j.ejrad.2006.05.003 10.1016/j.lungcan.2011.02.018 10.1016/j.ejrad.2007.10.002 10.1200/JCO.2009.27.4662 10.1016/j.athoracsur.2004.03.097 |
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| References | 10. Sadohara J, Fujimoto K, Müller NL, Kato S, Takamori S, Ohkuma K, Terasaki H, Hayabuchi N: Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas. Eur J Radiol 60(1): 70-9, 2006 1. Sung YM, Lee KS, Kim BT, Choi JY, Shim YM, Yi CA: 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups. J Nucl Med 47(10): 1628-34, 2006 9. Han J, Lee KS, Yi CA, Kim TS, Shim YM, Kim J, Kim K, Kwon OJ: Thymic epithelial tumors classified according to a newly established WHO scheme: CT and MR findings. Korean J Radiol 4(1): 46-53, 2003 12. Takahashi K, Al-Janabi NJ: Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging 32(6): 1325-39, 2010 11. Tomiyama N, Honda O, Tsubamoto M, Inoue A, Sumikawa H, Kuriyama K, Kusumoto M, Johkoh T, Nakamura H: Anterior mediastinal tumors: diagnostic accuracy of CT and MRI. Eur J Radiol 69(2): 280-8, 2009 3. Inoue A, Tomiyama N, Tatsumi M, Ikeda N, Okumura M, Shiono H, Inoue M, Higuchi I, Aozasa K, Johkoh T, Nakamura H, Hatazawa J: 18F-FDG PET for the evaluation of thymic epithelial tumors: Correlation with the World Health Organization classification in addition to dual-time-point imaging. Eur J Nucl Med Mol Imaging 36(8): 1219-25, 2009 7. Terzi A, Bertolaccini L, Rizzardi G, Luzzi L, Bianchi A, Campione A, Comino A, Biggi A: Usefulness of 18-F FDG PET/CT in the pre-treatment evaluation of thymic epithelial neoplasms. Lung Cancer 74(2): 239-43, 2011 4. Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Serizawa M, Koh Y, Hanaoka H, Tominaga H, Oriuchi N, Kondo H, Nakajima T, Yamamoto N: Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. J Clin Oncol 28(23): 3746-53, 2010 5. Nakajo M, Kajiya Y, Tani A, Yoneda S, Shirahama H, Higashi M, Nakajo M: 18FDG PET for grading malignancy in thymic epithelial tumors: significant differences in 18FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: preliminary study. Eur J Radiol 81(1): 146-51, 2010 6. Igai H, Matsuura N, Tarumi S, Chang SS, Misaki N, Go T, Ishikawa S, Yokomise H: Usefulness of [18F]fluoro-2-deoxy-D-glucose positron emission tomography for predicting the World Health Organization malignancy grade of thymic epithelial tumors. Eur J Cardiothorac Surg 40(1): 143-5, 2011 2. Endo M, Nakagawa K, Ohde Y, Okumura T, Kondo H, Igawa S, Nakamura Y, Tsuya A, Murakami H, Takahashi T, Yamamoto N, Ito I, Kameya T: Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors. Lung Cancer 61(3): 350-5, 2008 8. Park MS, Chung KY, Kim KD, Yang WI, Chung JH, Kim YS, Chang J, Kim JH, Kim SK, Kim SK: Prognosis of thymic epithelial tumors according to the new World Health Organization histologic classification. Ann Thorac Surg 78(3): 992-7, 2004 11 1 12 2 3 4 5 6 7 8 9 10 |
| References_xml | – reference: 1. Sung YM, Lee KS, Kim BT, Choi JY, Shim YM, Yi CA: 18F-FDG PET/CT of thymic epithelial tumors: usefulness for distinguishing and staging tumor subgroups. J Nucl Med 47(10): 1628-34, 2006 – reference: 6. Igai H, Matsuura N, Tarumi S, Chang SS, Misaki N, Go T, Ishikawa S, Yokomise H: Usefulness of [18F]fluoro-2-deoxy-D-glucose positron emission tomography for predicting the World Health Organization malignancy grade of thymic epithelial tumors. Eur J Cardiothorac Surg 40(1): 143-5, 2011 – reference: 4. Kaira K, Endo M, Abe M, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, Tsuya A, Nakamura Y, Naito T, Hayashi I, Serizawa M, Koh Y, Hanaoka H, Tominaga H, Oriuchi N, Kondo H, Nakajima T, Yamamoto N: Biologic correlation of 2-[18F]-fluoro-2-deoxy-D-glucose uptake on positron emission tomography in thymic epithelial tumors. J Clin Oncol 28(23): 3746-53, 2010 – reference: 10. Sadohara J, Fujimoto K, Müller NL, Kato S, Takamori S, Ohkuma K, Terasaki H, Hayabuchi N: Thymic epithelial tumors: comparison of CT and MR imaging findings of low-risk thymomas, high-risk thymomas, and thymic carcinomas. Eur J Radiol 60(1): 70-9, 2006 – reference: 7. Terzi A, Bertolaccini L, Rizzardi G, Luzzi L, Bianchi A, Campione A, Comino A, Biggi A: Usefulness of 18-F FDG PET/CT in the pre-treatment evaluation of thymic epithelial neoplasms. Lung Cancer 74(2): 239-43, 2011 – reference: 8. Park MS, Chung KY, Kim KD, Yang WI, Chung JH, Kim YS, Chang J, Kim JH, Kim SK, Kim SK: Prognosis of thymic epithelial tumors according to the new World Health Organization histologic classification. Ann Thorac Surg 78(3): 992-7, 2004 – reference: 12. Takahashi K, Al-Janabi NJ: Computed tomography and magnetic resonance imaging of mediastinal tumors. J Magn Reson Imaging 32(6): 1325-39, 2010 – reference: 3. Inoue A, Tomiyama N, Tatsumi M, Ikeda N, Okumura M, Shiono H, Inoue M, Higuchi I, Aozasa K, Johkoh T, Nakamura H, Hatazawa J: 18F-FDG PET for the evaluation of thymic epithelial tumors: Correlation with the World Health Organization classification in addition to dual-time-point imaging. Eur J Nucl Med Mol Imaging 36(8): 1219-25, 2009 – reference: 5. Nakajo M, Kajiya Y, Tani A, Yoneda S, Shirahama H, Higashi M, Nakajo M: 18FDG PET for grading malignancy in thymic epithelial tumors: significant differences in 18FDG uptake and expression of glucose transporter-1 and hexokinase II between low and high-risk tumors: preliminary study. Eur J Radiol 81(1): 146-51, 2010 – reference: 2. Endo M, Nakagawa K, Ohde Y, Okumura T, Kondo H, Igawa S, Nakamura Y, Tsuya A, Murakami H, Takahashi T, Yamamoto N, Ito I, Kameya T: Utility of 18FDG-PET for differentiating the grade of malignancy in thymic epithelial tumors. Lung Cancer 61(3): 350-5, 2008 – reference: 11. Tomiyama N, Honda O, Tsubamoto M, Inoue A, Sumikawa H, Kuriyama K, Kusumoto M, Johkoh T, Nakamura H: Anterior mediastinal tumors: diagnostic accuracy of CT and MRI. Eur J Radiol 69(2): 280-8, 2009 – reference: 9. Han J, Lee KS, Yi CA, Kim TS, Shim YM, Kim J, Kim K, Kwon OJ: Thymic epithelial tumors classified according to a newly established WHO scheme: CT and MR findings. Korean J Radiol 4(1): 46-53, 2003 – ident: 2 doi: 10.1016/j.lungcan.2008.01.003 – ident: 9 doi: 10.3348/kjr.2003.4.1.46 – ident: 6 doi: 10.1016/j.ejcts.2010.09.009 – ident: 3 doi: 10.1007/s00259-009-1082-4 – ident: 12 doi: 10.1002/jmri.22377 – ident: 1 – ident: 5 doi: 10.1016/j.ejrad.2010.08.010 – ident: 10 doi: 10.1016/j.ejrad.2006.05.003 – ident: 7 doi: 10.1016/j.lungcan.2011.02.018 – ident: 11 doi: 10.1016/j.ejrad.2007.10.002 – ident: 4 doi: 10.1200/JCO.2009.27.4662 – ident: 8 doi: 10.1016/j.athoracsur.2004.03.097 |
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| SubjectTerms | diagnosis FDG-PET Fluorodeoxyglucose F18 Humans Multimodal Imaging - methods Neoplasm Staging Neoplasms, Glandular and Epithelial - diagnostic imaging Neoplasms, Glandular and Epithelial - pathology pathology Positron-Emission Tomography - methods Radiopharmaceuticals staging thymic epithelial tumor Thymus Neoplasms - diagnostic imaging Thymus Neoplasms - pathology Tomography, X-Ray Computed |
| Title | The utility of FDG-PET in the diagnosis of thymic epithelial tumors |
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