Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation/Retention and Cellular Internalization

• Published in: Advanced materials (Weinheim) Vol. 28; no. 34; pp. 7340 - 7364
• Main Authors: Wang, Sheng, Huang, Peng, Chen, Xiaoyuan
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.09.2016
• Subjects: activatable surface ligands; changeable particle sizes; Drug Delivery Systems; hierarchical targeting; Humans; Ligands; Nanoparticles; Nanostructure; Neoplasms; Particle Size; Stimuli; stimuli-responsive nanoplatforms; Strategy; Surface chemistry; switchable surface charges; Tumor Microenvironment; Tumors; changeable particle sizes; stimuli-responsive nanoplatforms; switchable surface charges; hierarchical targeting; activatable surface ligands
• ISSN: 0935-9648; 1521-4095; 1521-4095
• DOI: 10.1002/adma.201601498

Targeted delivery of therapeutic agents is an important way to improve the therapeutic index and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor tissue accumulation/retention and enhanced cellular internalization should be considered simultaneously. So far, th...