Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sjögren's syndrome

• Published in: Chinese medical journal Vol. 136; no. 19; pp. 2297 - 2306
• Main Authors: Li, Mucong, Li, Mengtao, Qiao, Lin, Wu, Chanyuan, Xu, Dong, Zhao, Yan, Zeng, Xiaofeng
• Format: Journal Article
• Language: English
• Published: China Lippincott Williams & Wilkins 05.10.2023; Lippincott Williams & Wilkins Ovid Technologies; Wolters Kluwer
• Subjects: Apoptosis; Arthritis; Autoimmune diseases; Cells; Cytokines; Deoxyribonucleic acid; DNA; Drugs; Epigenetics; Exocrine glands; Genes; Granulocytes; Humans; Immune system; Janus Kinases - metabolism; Kinases; Lymphocytes; Lymphoma; Nervous system; Pathogenesis; Proteins; Review; Ribonucleic acid; RNA; Signal Transduction; Sjogren's Syndrome - drug therapy; Sjogren's Syndrome - metabolism; Skin diseases; STAT Transcription Factors - metabolism; STAT1 Transcription Factor - metabolism; STAT3 Transcription Factor - metabolism; Tumor necrosis factor-TNF

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with high prevalence and possible poor prognosis. Though the pathogenesis of pSS has not been fully elucidated, B cell hyperactivity is considered as one of the fundamental abnormalities in pSS patients. It has long been identifi...