KSHV 2.0: A Comprehensive Annotation of the Kaposi's Sarcoma-Associated Herpesvirus Genome Using Next-Generation Sequencing Reveals Novel Genomic and Functional Features

• Published in: PLoS pathogens Vol. 10; no. 1; p. e1003847
• Main Authors: Arias, Carolina, Weisburd, Ben, Stern-Ginossar, Noam, Mercier, Alexandre, Madrid, Alexis S., Bellare, Priya, Holdorf, Meghan, Weissman, Jonathan S., Ganem, Don
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.01.2014; Public Library of Science (PLoS)
• Subjects: Architecture; Biology; Cell Line; Deoxyribonucleic acid; DNA; Editing; Gene expression; Gene Expression Regulation, Viral - genetics; Genetic aspects; Genetic research; Genetic transcription; Genome, Viral; Genomes; Genomics; Health aspects; Herpesvirus 8, Human - genetics; High-Throughput Nucleotide Sequencing; Human herpesvirus 8; Humans; Infections; Kaposis sarcoma; Messenger RNA; Microbiological research; Open Reading Frames; Reading; RNA sequencing; RNA, Untranslated - genetics; RNA, Viral - genetics; United States

Productive herpesvirus infection requires a profound, time-controlled remodeling of the viral transcriptome and proteome. To gain insights into the genomic architecture and gene expression control in Kaposi's sarcoma-associated herpesvirus (KSHV), we performed a systematic genome-wide survey of...