全反式维甲酸对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响
目的 探讨全反式维甲酸（all—trans-retinoicacid，at-RA）对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响。方法 采用单侧输尿管结扎（unilateral ureteral obstructive，UUO）大鼠模型。40只大鼠随机分为假手术组、模型组、苯那普利组、维甲酸小剂量组、维甲酸大剂量组。于造模前1d至造模后14d分别给予维甲酸小剂量组、维甲酸大剂量组、苯那普利组全反式维甲酸10mg／（kg·d）、20rng／（kg·d）和苯那普利10mg／（kg·d）。假手术组、模型组给予等量的生理盐水。用免疫组化染色观察肾间质巨噬细胞数和Ⅲ型胶原（collagen111，Col11...
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| Published in | Xi'an jiao tong da xue xue bao. Journal of Xi'an Jiaotong University (medical sciences). Yi xue ban Vol. 27; no. 4; pp. 365 - 367 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
西安交通大学医学院第二附属医院,肾内科,陕西,西安,710004%西安交通大学医学院第二附属医院,心内科,陕西,西安,710004
2006
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1671-8259 |
| DOI | 10.3969/j.issn.1671-8259.2006.04.014 |
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| Abstract | 目的 探讨全反式维甲酸（all—trans-retinoicacid，at-RA）对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响。方法 采用单侧输尿管结扎（unilateral ureteral obstructive，UUO）大鼠模型。40只大鼠随机分为假手术组、模型组、苯那普利组、维甲酸小剂量组、维甲酸大剂量组。于造模前1d至造模后14d分别给予维甲酸小剂量组、维甲酸大剂量组、苯那普利组全反式维甲酸10mg／（kg·d）、20rng／（kg·d）和苯那普利10mg／（kg·d）。假手术组、模型组给予等量的生理盐水。用免疫组化染色观察肾间质巨噬细胞数和Ⅲ型胶原（collagen111，Col111）的表达。并常规行HE和Masson染色观察肾小管间质损伤指数。结果 维甲酸和苯那普利均能显著抑制肾间质巨噬细胞的浸润（P〈0．01），并且减低肾小管间质损伤指数和ColⅢ的表达（P〈0．05）。结论 维甲酸及苯那普利可能通过抑制肾间质巨噬细胞浸润而减轻UUO大鼠的肾损害。 |
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| AbstractList | R587.2; 目的 探讨全反式维甲酸(all-trans-retinoic acid,at-RA)对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响.方法 采用单侧输尿管结扎(unilateral ureteral obstructive,UUO)大鼠模型.40只大鼠随机分为假手术组、模型组、苯那普利组、维甲酸小剂量组、维甲酸大剂量组.于造模前1 d至造模后14 d分别给予维甲酸小剂量组、维甲酸大剂量组、苯那普利组全反式维甲酸10 mg/(kg·d)、20 mg/(kg·d)和苯那普利10 mg/(kg·d).假手术组、模型组给予等量的生理盐水.用免疫组化染色观察肾间质巨噬细胞数和Ⅲ型胶原(collagen Ⅲ,Col Ⅲ)的表达.并常规行HE和Masson染色观察肾小管间质损伤指数.结果 维甲酸和苯那普利均能显著抑制肾间质巨噬细胞的浸润(P＜0.01),并且减低肾小管间质损伤指数和Col Ⅲ的表达(P＜0.05).结论 维甲酸及苯那普利可能通过抑制肾间质巨噬细胞浸润而减轻UUO大鼠的肾损害. 目的 探讨全反式维甲酸（all—trans-retinoicacid，at-RA）对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响。方法 采用单侧输尿管结扎（unilateral ureteral obstructive，UUO）大鼠模型。40只大鼠随机分为假手术组、模型组、苯那普利组、维甲酸小剂量组、维甲酸大剂量组。于造模前1d至造模后14d分别给予维甲酸小剂量组、维甲酸大剂量组、苯那普利组全反式维甲酸10mg／（kg·d）、20rng／（kg·d）和苯那普利10mg／（kg·d）。假手术组、模型组给予等量的生理盐水。用免疫组化染色观察肾间质巨噬细胞数和Ⅲ型胶原（collagen111，Col111）的表达。并常规行HE和Masson染色观察肾小管间质损伤指数。结果 维甲酸和苯那普利均能显著抑制肾间质巨噬细胞的浸润（P〈0．01），并且减低肾小管间质损伤指数和ColⅢ的表达（P〈0．05）。结论 维甲酸及苯那普利可能通过抑制肾间质巨噬细胞浸润而减轻UUO大鼠的肾损害。 |
| Author | 朱丹 高登峰 宁宁 桂保松 姚钢炼 卫小红 周琳 安雪芬 |
| AuthorAffiliation | 西安交通大学医学院第二附属医院肾内科,陕西西安710004 西安交通大学医学院第二附属医院心内科,陕西西安710004 |
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| Author_FL | Zhu Dan Gao Dengfeng Yao Ganglian Gui Baosong Zhou Lin An Xuefen Wei Xiaohong Ning Ning |
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| Title | 全反式维甲酸对肾间质纤维化大鼠肾间质巨噬细胞浸润的影响 |
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