山楂叶总黄酮降血脂防治鹌鹑脂肪肝形成的实验研究
目的研究不同浓度的山楂叶总黄酮对鹌鹑血脂和脂肪肝形成的防治作用。方法将60只雌、雄各半的鹌鹑分成6组：正常组（N）喂以普通饲料;高脂饮食模型组（M）喂以高胆固醇脂饲料,诱发形成脂肪肝模型;脂必妥药物对照组（ZBT）、山楂叶总黄酮低、中、高浓度实验组（HLF1、HLF2、HLF3）在喂高脂饲料的同时分别喂1g/kg体重ZBT、20mg/kg、40mg/kg、80mg/kg体重山楂叶总黄酮溶液各1mL。实验6个月后取动物血清、肝脏,检测动物血清、肝脏组织中总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽...
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| Published in | Fu dan xue bao. Fudan University journal of medical science. Yi xue ban Vol. 36; no. 2; pp. 142 - 148 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
华东师范大学生命科学学院细胞生物学研究室,上海,200062
2009
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-8467 |
| DOI | 10.3969/j.issn.1672-8467.2009.02.004 |
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| Abstract | 目的研究不同浓度的山楂叶总黄酮对鹌鹑血脂和脂肪肝形成的防治作用。方法将60只雌、雄各半的鹌鹑分成6组：正常组（N）喂以普通饲料;高脂饮食模型组（M）喂以高胆固醇脂饲料,诱发形成脂肪肝模型;脂必妥药物对照组（ZBT）、山楂叶总黄酮低、中、高浓度实验组（HLF1、HLF2、HLF3）在喂高脂饲料的同时分别喂1g/kg体重ZBT、20mg/kg、40mg/kg、80mg/kg体重山楂叶总黄酮溶液各1mL。实验6个月后取动物血清、肝脏,检测动物血清、肝脏组织中总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）、谷丙转氨酶（AST）、谷草转氨酶（ALT）的含量,制备鹌鹑肝脏组织石蜡切片和电镜切片观察其病理学变化。结果山楂叶总黄酮实验各组与模型组相比,其血清和肝脏匀浆液的TC、TG、LDL-C、MDA、AST、ALT等含量均显著下降（P〈0.001）,而HDL-C、GSH、SOD含量则明显上升（P〈0.001）,且山楂叶总黄酮的浓度呈明显的量效关系。石蜡切片和电镜切片也显示山楂叶总黄酮实验组动物肝脏中的脂质积累和脂肪肝病理学变化明显轻于模型组。结论山楂叶总黄酮具有明显降低血脂、减轻动物肝脏内各类脂质沉积的作用,还具有很好的抗氧化作用,能显著地保护肝脏组织的生理生化功能,对由高脂饮食引起的高血脂和脂肪肝具有明显的防治作用。 |
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| AbstractList | 目的研究不同浓度的山楂叶总黄酮对鹌鹑血脂和脂肪肝形成的防治作用。方法将60只雌、雄各半的鹌鹑分成6组：正常组（N）喂以普通饲料;高脂饮食模型组（M）喂以高胆固醇脂饲料,诱发形成脂肪肝模型;脂必妥药物对照组（ZBT）、山楂叶总黄酮低、中、高浓度实验组（HLF1、HLF2、HLF3）在喂高脂饲料的同时分别喂1g/kg体重ZBT、20mg/kg、40mg/kg、80mg/kg体重山楂叶总黄酮溶液各1mL。实验6个月后取动物血清、肝脏,检测动物血清、肝脏组织中总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）、丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）、谷丙转氨酶（AST）、谷草转氨酶（ALT）的含量,制备鹌鹑肝脏组织石蜡切片和电镜切片观察其病理学变化。结果山楂叶总黄酮实验各组与模型组相比,其血清和肝脏匀浆液的TC、TG、LDL-C、MDA、AST、ALT等含量均显著下降（P〈0.001）,而HDL-C、GSH、SOD含量则明显上升（P〈0.001）,且山楂叶总黄酮的浓度呈明显的量效关系。石蜡切片和电镜切片也显示山楂叶总黄酮实验组动物肝脏中的脂质积累和脂肪肝病理学变化明显轻于模型组。结论山楂叶总黄酮具有明显降低血脂、减轻动物肝脏内各类脂质沉积的作用,还具有很好的抗氧化作用,能显著地保护肝脏组织的生理生化功能,对由高脂饮食引起的高血脂和脂肪肝具有明显的防治作用。 R575.5; 目的 研究不同浓度的山楂叶总黄酮对鹌鹑血脂和脂肪肝形成的防治作用.方法 将60只雌、雄各半的鹌鹑分成6组:正常组(N)喂以普通饲料;高脂饮食模型组(M)喂以高胆固醇脂饲料,诱发形成脂肪肝模型;脂必妥药物对照组(ZBT)、山楂叶总黄酮低、中、高浓度实验组(HLF1、HLF2、HLF3)在喂高脂饲料的同时分别喂1 g/kg体重ZBT、20 mg/kg、40 mg/kg、80 mg/kg体重山楂叶总黄酮溶液各1 mL.实验6个月后取动物血清、肝脏,检测动物血清、肝脏组织中总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、谷丙转氨酶(AST)、谷草转氨酶(ALT)的含量,制备鹌鹑肝脏组织石蜡切片和电镜切片观察其病理学变化.结果 山楂叶总黄酮实验各组与模型组相比,其血清和肝脏匀浆液的TC、TG、LDL-C、MDA、AST、ALT等含量均显著下降(P<0.001),而HDL-C、GSH、SOD含量则明显上升(P<0.001),且山楂叶总黄酮的浓度呈明显的量效关系.石蜡切片和电镜切片也显示山楂叶总黄酮实验组动物肝脏中的脂质积累和脂肪肝病理学变化明显轻于模型组.结论 山楂叶总黄酮具有明显降低血脂、减轻动物肝脏内各类脂质沉积的作用,还具有很好的抗氧化作用,能显著地保护肝脏组织的生理生化功能,对由高脂饮食引起的高血脂和脂肪肝具有明显的防治作用. |
| Abstract_FL | Objective To investigate the effect of hawthorn leaf flavonoids (HLFs) with the different concentrations in prevention of high blood lipids and fatty liver in quails. Methods Sixty quails were divided into six groups:normal (N),high lipids food model (M),positive control (ZBT),HLF1,HLF2 and HLF3 groups.The animals in the N group were fed with normal food,while the M group was feed with high lipids food to establish the animal model of fatty liver.Besides high-fat diet,HLF1,HLF2 and HLF3 groups were also fed with 1 mL HLFs in the doses of 20 mg/kg,40 mg/kg and 80 mg/kg respectively.The ZBT group was fed with 1 g/kg of ZhiBiTuo and used as the positive control.After the experiments of six months,the serum and liver of the quails were taken and used to evaluate the contents of total cholesterol (TC),triglyceride (TG),high density lipid cholesterol(HDL-C),low density lipid cholesterol (LDL-C),superoxide dismutase (SOD),malondialdehyde (MDA),glutathione (GSH),alanine amino transferase (ALT) and glutamic oxaloacetic transaminase (AST).Meanwhile,the microscopic and electronic microscopic sections were used to observe the pathological changes of the livers of the quails. Results Compared with the M group,HLFs significantly lowered the content of TC,TG,LDL-C,MDA,AST and ALT in the serum and livers of the quails in other groups (P<0.001).However,the levels of HDL-C,SOD and GSH of the other groups were increased markedly (P<0.001).Moreover,the ratios of increase/decrease in the three HLF groups were depended on the concentrations of HLFs.Also,better liver structure and less lipid accumulation were also observed in the HLF groups when compared to the M group. Conclusions These results showed HLFs can lower blood lipid and cholesterol accumulation,improve the antioxidant capacity and protect the physiological function of liver.So,HLFs were effective in preventing and treating high blood lipids and fatty liver induced by high-fat diet. |
| Author | 叶希韵 徐敏华 李晓峰 王耀发 |
| AuthorAffiliation | 华东师范大学生命科学学院细胞生物学研究室,上海200062 |
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| Author_FL | Wang Yao-fa XU Min-hua YE Xi-yun LI Xiao-feng |
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| Keywords | 脂肪肝 血脂 antioxidant capacity 鹌鹑 hawthorn leaf flavonoids 抗氧化作用 山楂叶总黄酮 fatty liver blood lipid quail |
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| SubjectTerms | 山楂叶总黄酮 抗氧化作用 脂肪肝 血脂 鹌鹑 |
| Title | 山楂叶总黄酮降血脂防治鹌鹑脂肪肝形成的实验研究 |
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