急性缺血性卒中血清超敏C-反应蛋白与改良TOAST分型和OCSP分型关系的研究

探讨急性缺血性卒中患者血清超敏C-反应蛋白（hs-CRP）表达变化与改良TOAST分型和OCSP分型之间的关系。实验室检测显示,缺血性卒中组患者血清hs-CRP表达水平高于正常对照组[（13.68±6.92）mg/L对（3.98±0.76）mg/L;t=6.922,P=0.002]。TOAST分型中以心源性栓塞型患者血清hs-CRP水平[（16.82±6.16）mg/L]最高,然后依次为动脉粥样硬化血栓形成型[（15.71±5.68）mg/L]、不明病因型[（10.06±3.89）mg/L]和小动脉型[（9.86±3.75）mg/L,P=0.027];OCSP分型由高至低分别为完全前循环梗死型...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 14; no. 10; pp. 897 - 901
Main Author 常华军 全亚萍 陈顺中
Format Journal Article
LanguageChinese
Published 225300,南京中医药大学泰州附属医院神经内科 2014
Subjects
C反应蛋白质
卒中
卒中
Stroke
C-reactive protein
C反应蛋白质
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ISSN1672-6731
DOI10.3969/j.issn.1672-6731.2014.10.013

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Summary:探讨急性缺血性卒中患者血清超敏C-反应蛋白（hs-CRP）表达变化与改良TOAST分型和OCSP分型之间的关系。实验室检测显示,缺血性卒中组患者血清hs-CRP表达水平高于正常对照组[（13.68±6.92）mg/L对（3.98±0.76）mg/L;t=6.922,P=0.002]。TOAST分型中以心源性栓塞型患者血清hs-CRP水平[（16.82±6.16）mg/L]最高,然后依次为动脉粥样硬化血栓形成型[（15.71±5.68）mg/L]、不明病因型[（10.06±3.89）mg/L]和小动脉型[（9.86±3.75）mg/L,P=0.027];OCSP分型由高至低分别为完全前循环梗死型[（17.02±6.98）mg/L]、后循环梗死型[（15.91±7.12）mg/L]、部分前循环梗死型[（12.83±4.95）mg/L]和腔隙性梗死型[（10.61±5.73）mg/L,P=0.005]。提示急性缺血性卒中患者血清hs-CRP表达水平在改良TOAST分型和OCSP分型各亚型中存在差异,可以此指导临床治疗和判断预后。
Bibliography:CHANG Hua-jun, QUAN Ya-ping, CHEN Shun-zhong（ Department of Neurology, Taizhou Affiliated Hospital of Nanjing University of Chinese Medicine, Taizhou 225300, Jiangsu, China）
Stroke; C-reactive protein
This paper aims to investigate the relationship between serum high-sensitivity C-reactiveprotein（hs-CRP） level and modified TOAST classification as well as OCSP subtypes in patients with acuteischemic stroke. Serum hs-CRP was measured in 240 patients with acute ischemic stroke and 120 normalcontrols. All patients were classified according to modified TOAST classification and OCSP criteria. Serumhs-CRP levels in acute ischemic stroke group were significantly higher than those in normal control group[（13.68 ± 6.92） mg/L vs（3.98 ± 0.76） mg/L; t = 6.922, P = 0.002]. Among modified TOAST subtypes, thehighest serum hs- CRP level was in cardioembolism（CE） group [（16.82 ± 6.16） mg/L], followed byarterothrombosis（AT） group [（15.17 ± 5.68） mg/L], stroke of undetermined etiology（SUD） group [（10.06 ±3.89） mg/L] and small arte
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2014.10.013