STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

• Published in: Nature Cell Biology Vol. 10; no. 6; pp. 688 - 697
• Main Authors: Hawkins, April, Seth, Malini, Zhang, Zhu-Shan, Stiber, Jonathan, Finch, Elizabeth, Rosenberg, Paul, Williams, R. Sanders, Burch, Jarrett, Malouf, Nadia, Wang, Sunny, Graham, Victoria, Ward, Cary C, Eu, Jerry P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2008; Nature Publishing Group
• Subjects: Animals; Biomedical and Life Sciences; Calcium; Calcium - metabolism; Calcium channels; Calcium Channels - metabolism; Calcium Signaling; Cancer Research; Cell Biology; Cell Line; Developmental Biology; Endoplasmic reticulum; Fatigue; Gene Silencing; Life Sciences; Membrane Glycoproteins - metabolism; Membrane Glycoproteins - physiology; Membrane proteins; Mice; Models, Biological; Models, Genetic; Muscle Contraction; Muscles; Muscles - metabolism; Musculoskeletal system; Patch-Clamp Techniques; Physiological aspects; Plasma; Sarcoplasmic Reticulum - metabolism; Sensors; Signal Transduction; Stem Cells; Stromal Interaction Molecule 1; United States

It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells. However, little is known about STIM1 in excitable cells, such as striat...