Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans

• Published in: Journal of applied physiology (1985) Vol. 108; no. 6; pp. 1487 - 1496
• Main Authors: Timmons, James A., Knudsen, Steen, Rankinen, Tuomo, Koch, Lauren G., Sarzynski, Mark, Jensen, Thomas, Keller, Pernille, Scheele, Camilla, Vollaard, Niels B. J., Nielsen, Søren, Åkerström, Thorbjörn, MacDougald, Ormond A., Jansson, Eva, Greenhaff, Paul L., Tarnopolsky, Mark A., van Loon, Luc J. C., Pedersen, Bente K., Sundberg, Carl Johan, Wahlestedt, Claes, Britton, Steven L., Bouchard, Claude
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.06.2010
• Subjects: Biological and medical sciences; Biomarkers; Deoxyribonucleic acid; DNA; endurance training; Exercise; Family studies; Fundamental and applied biological sciences. Psychology; Gene expression; Gene mapping; Genetic diversity; Genetic variance; genotype; Genotype & phenotype; Heterogeneity; Humans; Male; Mortality; Muscle Proteins - genetics; NATURAL SCIENCES; NATURVETENSKAP; Oxygen consumption; Oxygen Consumption - genetics; personalized medicine; Phenotype; Physical Endurance - genetics; Physical Exertion - physiology; Physical Fitness - physiology; Physical training; Polymorphism; Polymorphism, Single Nucleotide - genetics; Regression analysis; Ribonucleic acid; Risk factors; RNA; Young Adult; Physical exercise; Human; Vertebrata; Physical training; Mammalia; Classification; endurance training; Genotype; Endurance; personalized medicine

A low maximal oxygen consumption (V̇o 2max ) is a strong risk factor for premature mortality. Supervised endurance exercise training increases V̇o 2max with a very wide range of effectiveness in humans. Discovering the DNA variants that contribute to this heterogeneity typically requires substantial...