Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia–reperfusion-induced kidney injury via the JAK/STAT pathway

• Published in: Biological research Vol. 53; no. 1; pp. 1 - 12
• Main Authors: Zhao, Xiaoying, Zhang, Erfei, Ren, Xiaofen, Bai, Xiaoli, Wang, Dongming, Bai, Ling, Luo, Danlei, Guo, Zheng, Wang, Qiang, Yang, Jianxin
• Format: Journal Article
• Language: English
• Published: Santiago BioMed Central Ltd 03.07.2020; BioMed Central; Sociedad de Biología de Chile; BMC
• Subjects: Analysis; Animals; Apoptosis; BAX protein; Bcl-2 protein; BIOLOGY; Caspase-3; Dexmedetomidine; DNA nucleotidylexotransferase; Edaravone; Epithelial cells; Free radicals; Hypoxia; Inflammation; Ischemia; Ischemia–reperfusion injury; JAK/STAT; Janus kinase; Janus kinase 2; Kidney diseases; Kidneys; Kinases; Medical research; Membrane potential; Mitochondria; Neutrophils; Oxidative stress; Phosphorylation; Protein kinase; Proteins; Reperfusion; Signal transduction; Stat1 protein; Stat3 protein; Studies; Transcription; Transmission electron microscopy; Tyrosine; Western blotting; Ischemia-reperfusion injury; Mitochondria; Edaravone; JAK/STAT

Kidney ischemia-reperfusion injury is a common pathophysiological phenomenon in the clinic. A large number of studies have found that the tyrosine protein kinase/signal transducer and activator of transcription (JAK/STAT) pathway is involved in the development of a variety of kidney diseases and ren...