Covalent IR820-PEG-diamine nanoconjugates for theranostic applications in cancer

• Published in: International journal of nanomedicine Vol. 9; no. Issue 1; pp. 4631 - 4648
• Main Authors: Fernandez-Fernandez, Alicia, Manchanda, Romila, Carvajal, Denny A, Lei, Tingjun, Srinivasan, Supriya, McGoron, Anthony J
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Algorithms; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacokinetics; Cancer; Cancer therapies; Care and treatment; Cell Line, Tumor; Cell Proliferation - drug effects; Chemotherapy; Diamines - chemistry; Diamines - toxicity; Drug delivery systems; Drugs; Dyes; Fever; fluorescent imaging; Humans; Hyperthermia; Hyperthermia, Induced; image-guided therapy; Indocyanine Green - analogs & derivatives; Indocyanine Green - chemistry; Indocyanine Green - pharmacokinetics; Indocyanine Green - toxicity; Mice; Nanoconjugates - chemistry; Nanoconjugates - toxicity; Nanoparticles; Nanotechnology; NMR; Nuclear magnetic resonance; Optical Imaging - methods; Original Research; Physiological aspects; Plasma; Polyethylene glycol; Polyethylene Glycols - chemistry; Polyethylene Glycols - toxicity; Properties; Surgery, Computer-Assisted; Tissue Distribution; Vehicles; United States; Florida; United States > US; nanotechnology; hyperthermia; fluorescent imaging; image-guided therapy

Near-infrared dyes can be used as theranostic agents in cancer management, based on their optical imaging and localized hyperthermia capabilities. However, their clinical translatability is limited by issues such as photobleaching, short circulation times, and nonspecific biodistribution. Nanoconjug...